中药治疗广泛耐药肺结核多中心随机对照临床观察
发布时间：2018-08-26 18:46
【摘要】：目的评价中药治疗广泛耐药肺结核(XDR-TB)患者的临床疗效。方法选取2013年11月至2015年11月来自6家结核病定点诊疗单位的XDR-TB患者80例,将所有患者随机分为4组,每组20例。益肺通络方组给予益肺通络方颗粒剂冲服,每次18.54 g,每日2次;抗痨清肺方组给予抗痨清肺方颗粒剂冲服每次15.08 g,每日2次;益肺通络方合并雾化组在益肺通络方组治疗基础上联合雾化益肺精白方安瓿装水剂,每次10 ml,每次5~10 min;抗痨清肺方合并雾化组在抗痨清肺方治疗基础上联合雾化益肺精白方安瓿装水剂,每次10 ml,每次5~10 min。各组均连续治疗12个月。观察并比较各组患者治疗后的治疗转归情况、病灶吸收程度及中医证候疗效。结果治疗结束后完全符合研究方案的患者共计61例,其治疗成功率为23.0%,总死亡率为6.5%,肺部病灶吸收率为37.7%,中医证候总有效率达63.9%,以上各指标各组间比较差异均无统计学意义(P0.05)。61例患者在治疗过程中均无药物不良反应发生。结论中药治疗XDR-TB可有效促进痰菌阴转及肺部病灶吸收,有效改善患者临床症状。
[Abstract]:Objective to evaluate the clinical efficacy of traditional Chinese medicine (TCM) in the treatment of extensively resistant pulmonary tuberculosis (XDR-TB). Methods from November 2013 to November 2015, 80 patients with XDR-TB were randomly divided into 4 groups, 20 patients in each group. Yifei Tongluo decoction group was given Yifei Tongluo granule, 18.54 g per day, 2 times a day, the anti-tuberculosis Qingfei prescription group was given anti-tuberculosis Qingfei granule 15.08 g, twice a day. Yifei Tongluo recipe combined with atomization group combined with atomization of Baifang ampoule containing water on the basis of treatment of Yifei Tongluo recipe group, 10 ml, 10 min; anti-tuberculosis Qingfei prescription combined with atomization group combined with anti-tuberculosis Qingfei prescription on the basis of treatment of anti-tuberculosis Qingfei prescription combined with atomization of Yifei essence white square ampoule containing water, 10 ml, each time 5 minutes 10 min. All groups were treated continuously for 12 months. To observe and compare the therapeutic outcome, the degree of focus absorption and the curative effect of TCM syndrome. Results A total of 61 patients with complete compliance with the study program after treatment were included. The successful rate of treatment was 23.0, the total mortality was 6.5, the absorption rate of pulmonary focus was 37.7 and the total effective rate of TCM syndromes was 63.9. There was no significant difference among the above indexes (P0.05) .61 patients had no adverse drug reactions in the course of treatment. Conclusion Chinese medicine can effectively promote sputum negative transformation and pulmonary focus absorption, and improve the clinical symptoms of patients with XDR-TB.
【作者单位】： 长沙市中心医院;武汉市医疗救治中心;丽水市中医院;福建省福州肺科医院;郴州市第二人民医院;衡阳市第三人民医院;
【基金】：国家卫生和计划生育委员会中医药防治重大传染病项目(2013ZX10005004)
【分类号】：R259
本文编号：2205824
[Abstract]:Objective to evaluate the clinical efficacy of traditional Chinese medicine (TCM) in the treatment of extensively resistant pulmonary tuberculosis (XDR-TB). Methods from November 2013 to November 2015, 80 patients with XDR-TB were randomly divided into 4 groups, 20 patients in each group. Yifei Tongluo decoction group was given Yifei Tongluo granule, 18.54 g per day, 2 times a day, the anti-tuberculosis Qingfei prescription group was given anti-tuberculosis Qingfei granule 15.08 g, twice a day. Yifei Tongluo recipe combined with atomization group combined with atomization of Baifang ampoule containing water on the basis of treatment of Yifei Tongluo recipe group, 10 ml, 10 min; anti-tuberculosis Qingfei prescription combined with atomization group combined with anti-tuberculosis Qingfei prescription on the basis of treatment of anti-tuberculosis Qingfei prescription combined with atomization of Yifei essence white square ampoule containing water, 10 ml, each time 5 minutes 10 min. All groups were treated continuously for 12 months. To observe and compare the therapeutic outcome, the degree of focus absorption and the curative effect of TCM syndrome. Results A total of 61 patients with complete compliance with the study program after treatment were included. The successful rate of treatment was 23.0, the total mortality was 6.5, the absorption rate of pulmonary focus was 37.7 and the total effective rate of TCM syndromes was 63.9. There was no significant difference among the above indexes (P0.05) .61 patients had no adverse drug reactions in the course of treatment. Conclusion Chinese medicine can effectively promote sputum negative transformation and pulmonary focus absorption, and improve the clinical symptoms of patients with XDR-TB.
【作者单位】： 长沙市中心医院;武汉市医疗救治中心;丽水市中医院;福建省福州肺科医院;郴州市第二人民医院;衡阳市第三人民医院;
【基金】：国家卫生和计划生育委员会中医药防治重大传染病项目(2013ZX10005004)
【分类号】：R259
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