下气汤加减治疗胃食管反流病（中虚气滞证）临床疗效观察
发布时间：2018-08-29 17:25
【摘要】：目的:观察下气汤加减治疗中虚气滞型胃食管反流病(GERD)患者的临床症状改善情况,从理论和临床研究两方面讨论气机升降理论在GERD病机、辨证及治疗中的作用,提供治疗的新思路和新方药。方法:将60名符合纳入标准的中虚气滞型GERD患者,随机分为试验组(例)和对照组(30例),试验组给予下气汤加减(每日1副),对照组给予雷贝拉唑肠溶胶囊(早晚餐前各1粒),疗程均为8周,观察两组在治疗前,治疗4周及8周后,临床症状、体征、不良反应等方面的变化,并对情况进行记录、分析,并电话随访,观察长期疗效及复发情况。结果:两组药物对均有一定的疗效,试验组8周总有效率为93.4%,高于对照组76.7%,试验组疗效更优(P0.05)。中医症状积分比较显示:两组药物均有效果,试验组优于对照组(P0.05),且在缓解反酸、胃胀、便溏、咽异感等方面的效果优于对照组(P0.05)。GERD-HRQL积分比较,亦显示试验组有更好的临床疗效(P0.05)。试验组无论在中医症状积分、GERD-HRQL积分还是总有效率,治疗8周,疗效均优于治疗4周(P0.05)。结论:下气汤加减治疗GERD(中虚气滞型)患者的疗效优于标准治疗。且在改善食管外症状方面有更好的疗效,是临床治疗GERD(中虚气滞型)的有效方法,有进一步研究的价值。治疗周期建议为8周。
[Abstract]:Objective: to observe the improvement of clinical symptoms of patients with moderate deficiency of qi stagnation gastroesophageal reflux disease (GERD) treated by Xiaqi decoction, and to discuss the role of Qi mechanism ascending and descending theory in the pathogenesis, syndrome differentiation and treatment of GERD from two aspects: theory and clinical study. To provide new ideas and new prescriptions for treatment. Methods: sixty GERD patients with moderate asthenia and Qi stagnation were included in the study. They were randomly divided into the experimental group (n = 30) and the control group (n = 30). The experimental group was treated with Xiaqi decoction (1 pair per day) and the control group (1 capsule before the morning and evening meal) for 8 weeks. After 4 weeks and 8 weeks of treatment, the changes of clinical symptoms, signs and adverse reactions were recorded, analyzed and followed up by telephone to observe the long-term curative effect and recurrence. Results: both groups had certain curative effects. The total effective rate of the experimental group was 93.4w, which was higher than that of the control group (76.7g). The effect of the trial group was better than that of the control group (P0.05). TCM symptom score comparison showed that: the two groups of drugs are effective, the experimental group is better than the control group (P0.05), and in the relief of acid, stomach distention, loose stools, pharynx and other aspects of the effect is better than the control group (P0.05). GERD-HRQL score comparison, also shows that the experimental group has a better clinical efficacy (P0.05). In the experimental group, the GERD-HRQL score or the total effective rate were better than that of the treatment for 4 weeks after 8 weeks of treatment (P0.05). Conclusion: Xiaqi decoction is superior to standard treatment in treating GERD patients. It is an effective method for the treatment of GERD (deficiency of Qi stagnation) and has the value of further study. The treatment cycle is recommended for 8 weeks.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259
本文编号：2211902
[Abstract]:Objective: to observe the improvement of clinical symptoms of patients with moderate deficiency of qi stagnation gastroesophageal reflux disease (GERD) treated by Xiaqi decoction, and to discuss the role of Qi mechanism ascending and descending theory in the pathogenesis, syndrome differentiation and treatment of GERD from two aspects: theory and clinical study. To provide new ideas and new prescriptions for treatment. Methods: sixty GERD patients with moderate asthenia and Qi stagnation were included in the study. They were randomly divided into the experimental group (n = 30) and the control group (n = 30). The experimental group was treated with Xiaqi decoction (1 pair per day) and the control group (1 capsule before the morning and evening meal) for 8 weeks. After 4 weeks and 8 weeks of treatment, the changes of clinical symptoms, signs and adverse reactions were recorded, analyzed and followed up by telephone to observe the long-term curative effect and recurrence. Results: both groups had certain curative effects. The total effective rate of the experimental group was 93.4w, which was higher than that of the control group (76.7g). The effect of the trial group was better than that of the control group (P0.05). TCM symptom score comparison showed that: the two groups of drugs are effective, the experimental group is better than the control group (P0.05), and in the relief of acid, stomach distention, loose stools, pharynx and other aspects of the effect is better than the control group (P0.05). GERD-HRQL score comparison, also shows that the experimental group has a better clinical efficacy (P0.05). In the experimental group, the GERD-HRQL score or the total effective rate were better than that of the treatment for 4 weeks after 8 weeks of treatment (P0.05). Conclusion: Xiaqi decoction is superior to standard treatment in treating GERD patients. It is an effective method for the treatment of GERD (deficiency of Qi stagnation) and has the value of further study. The treatment cycle is recommended for 8 weeks.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259
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