四神丸加味用于大肠癌围手术期治疗的临床研究

发布时间：2018-09-02 09:26

【摘要】：目的:研究四神丸加味在大肠癌围手术期治疗的临床疗效,进而探索中医药参与大肠癌围手术期治疗的临床疗效和应用价值。材料与方法:搜集了116例以脾肾阳虚为主要证候表现的大肠癌临床病例,按照治疗方法的不同,将其随机分为治疗组和对照组各58例,根据围手术期术前、术后中医证候的差异,辩证论治。治疗组患者在西医药常规治疗的基础上联合中医药治疗,即术前1周和术后36小时开始分别给予相应的中药汤剂口服。对照组患者只进行西医药常规治疗,然后分析比较两组患者的临床资料。结果:1.术后肛门排气时间两组比较得T=2.028,P=0.045(P0.05),其中治疗组(4.103±0.831)天,对照组(4.414±0.817)天;术后住院时间两组比较得T=2.194,P=0.030(P0.05),其中治疗组(11.224±2.464)天,对照组(12.362±3.088)天。2.出现术后并发症情况比较,治疗组发生4例,发生率为6.7%;对照组发生14例,发生率为24.1%。其中治疗组只出现一种并发症的占5.2%,同时出现两种并发症为1.7%,同时出现3、4种的为0;对照组只出现一种并发症的占24.1%,同时出现2、3、4种并发症的为0。3.两组患者在治疗前后中医症候的改善比较,治疗组要优于对照组,治疗组总有效率为91.38%,对照组总有效率为75.86%,秩和Z=-2.713,P=0.0140.05,两组之间的差异有统计学意义。结论:1.四神丸加味参与大肠癌围手术期治疗的临床疗效显著,能促进术后胃肠功能和身体的恢复,进而缩短了术后排气时间和住院时间,并能预防或减少术后一些并发症的发生,能有效地改善大肠癌围手术期的中医症候,提高临床疗效。2.通过四神丸加味在大肠癌围手术期应用的研究,体现出了中医药在大肠癌围手术期的优势和临床应用价值,值得进一步深入研究。
[Abstract]:Objective: to study the clinical effect of Sishen Pill in the perioperative treatment of colorectal cancer, and to explore the clinical efficacy and application value of TCM in the perioperative treatment of colorectal cancer. Materials and methods: 116 cases of colorectal cancer with deficiency of spleen and kidney yang as the main syndromes were collected and randomly divided into treatment group (58 cases) and control group (58 cases). The difference of syndrome of traditional Chinese medicine after operation, dialectical treatment. The patients in the treatment group were treated with traditional Chinese medicine combined with traditional Chinese medicine on the basis of routine treatment, I. E. 1 week before operation and 36 hours after operation. The patients in the control group were treated with routine western medicine only, and the clinical data of the two groups were analyzed and compared. The result is 1: 1. The postoperative anal exhaust time was compared between the two groups (P0.05), including the treatment group (4.103 卤0.831) days, the control group (4.414 卤0.817) days, the postoperative hospitalization time between the two groups (P0.05), the treatment group (11.224 卤2.464) days, the control group (12.362 卤3.088) days. There were 4 cases in the treatment group (6.7%) and 14 cases in the control group (24.1%). Among them, only one complication occurred in the treatment group (5.2%), two kinds of complications (1.7%) and three kinds of complications (0%) in the treatment group, while in the control group there was only one complication (24.1%) and the other two complications (0.3%). The improvement of TCM symptoms in the two groups before and after treatment, the treatment group is better than the control group, the total effective rate of the treatment group is 91.38, the total effective rate of the control group is 75.86. Conclusion 1. The clinical effect of Sishen Pill in the perioperative treatment of colorectal cancer is remarkable. It can promote the recovery of gastrointestinal function and body after operation, thus shorten the time of exhaust and hospital stay after operation, and can prevent or reduce the occurrence of some postoperative complications. Can effectively improve the perioperative period of colorectal cancer TCM symptoms, improve the clinical efficacy. 2. The application of Sishen Pill in the perioperative period of colorectal cancer shows the advantages and clinical application value of TCM in perioperative period of colorectal cancer, which is worthy of further study.
【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R273
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本文编号：2218938