加减易黄汤治疗脾虚湿热型复发性外阴阴道假丝酵母菌病的临床研究

发布时间：2018-09-03 19:47

【摘要】：目的:观察加减易黄汤治疗脾虚湿热型复发性外阴阴道假丝酵母菌病的临床疗效,初步探讨其作用机制。方法:选取脾虚湿热型复发性外阴阴道假丝酵母菌病患者60例,随机分为治疗组和对照组,各30例。将治疗过程分为强化阶段、巩固阶段:强化阶段治疗组口服中药汤剂加减易黄汤+克霉唑阴道片(阴道放置),对照组克霉唑阴道片(阴道放置),停药3天后,真菌转阴的患者进入巩固阶段;巩固阶段治疗组中药汤剂口服+克霉唑阴道片(阴道放置),对照组克霉唑阴道片(阴道放置),每月月经干净3天后开始用药7天,连续治疗3个月经周期。观察两组患者治疗前后临床症状疗效、各阴道微生态指标恢复情况及复发率。结果:临床症状、体征疗效情况比较,两组患者治疗后,治疗组总有效率90%,对照组总有效率83%,差异有统计学意义(P0.05);临床症状、体征积分情况比较,两组临床症状体征积分差异有统计学意义(P0.05),治疗组在改善临床症状体征方面由于对照组;阴道菌群的密集度、阴道环境清洁度、阴道分泌物PH、H2O2比较分析,差异有统计学意义(P0.01或者P0.05);累计治疗疗程对比治疗组在维持阴道微生态方面优于对照组。结论:加减易黄汤治疗脾虚湿热型复发性外阴阴道假丝酵母菌病疗效确切,改善临床症状同时在恢复及维持阴道微生态环境方面具有明显优势。
[Abstract]:Objective: to observe the clinical effect of Jiajianyihuang decoction on recurrent vulvovaginal candidiasis of spleen deficiency damp-heat type, and to explore its mechanism. Methods: 60 patients with recurrent vulvovaginal candidiasis were randomly divided into treatment group and control group. The treatment process was divided into strengthening stage, consolidation stage: the treatment group took oral Chinese traditional medicine decoction plus Yihuangtang clotrimazole vaginal tablet (vaginal placement), the control group clotrimazole vaginal tablet (vaginal placement), 3 days after the withdrawal of drugs, In the treatment group, clotrimazole vaginal tablet (vaginal placement) was taken orally, while in the control group clotrimazole vaginal tablet (vaginal placement) began to be used for 7 days after 3 days of menstruation. Continuous treatment for 3 menstrual cycles. The clinical symptoms, recovery and recurrence rate of each vaginal microecological index were observed before and after treatment. Results: the clinical symptoms and signs were compared. After treatment, the total effective rate of the treatment group was 90%, the total effective rate of the control group was 833%, the difference was statistically significant (P0.05), the scores of clinical symptoms and signs were compared. Two groups of clinical symptoms and signs score difference was statistically significant (P0.05), the treatment group in the improvement of clinical symptoms and signs due to the control group, vaginal flora density, vaginal environment cleanliness, vaginal secretion PH,H2O2 comparative analysis, The difference was statistically significant (P0.01 or P0.05); the treatment group was superior to the control group in maintaining vaginal microecology. Conclusion: Yi-Huang decoction is effective in treating recurrent vulvovaginal candidiasis of spleen deficiency and damp-heat type, and the improvement of clinical symptoms has obvious advantages in recovering and maintaining the vaginal microecological environment at the same time.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R271.9

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