益肾补脾方对慢性肾脏病CKD3期脾肾气虚证患者钙磷代谢的影响
发布时间：2018-09-04 10:53
【摘要】：目的:观察益肾补脾方对慢性肾脏病CKD3期脾肾气虚证患者钙磷代谢异常的影响。方法:本研究通过选取60例2014年10月至2016年10月在广西中医药大学第一附属医院肾内科门诊就诊或住院的符合纳入标准和排除标准的慢性肾脏病3期的脾肾气虚型患者,随机分为对照组和治疗组,对照组给予基础治疗加碳酸钙D3,治疗组在对照组的基础上加用益肾补脾方,疗程6个月。观察患者的血钙、血磷、全型甲状旁腺激素、肾功能、24小时尿蛋白定量、中医症候量化评分等指标,并进行安全性评价,为中医治疗慢性肾脏病CKD3期脾肾气虚钙磷紊提供临床依据。结果:经过6个月的临床研究,经统计两组数据所得结果:(1)血清钙:治疗后,治疗组血清钙平均值为2.13±0.19,对照组平均值为1.92±0.13,两组结果经过比较,P0.05,差异有统计学意义,治疗组疗效优于对照组。(2)血清磷:治疗后,治疗组血清磷平均值为1.34±0.02,对照组平均值为1.45±0.03,两组结果经过比较,P0.05,差异有统计学意义,治疗组疗效优于对照组。(3)全型甲状旁腺激素(iPTH):治疗后,治疗组iPTH平均值为72.16±6.27,对照组平均值为76.12±6.43,两组结果经过比较,P0.05,差异有统计学意义,治疗组疗效优于对照组。(4)血肌酐:治疗后,治疗组血肌酐平均值为123.02±17.95,对照组平均值为132.28±29.22,两组结果经过比较,P0.05,差异有统计学意义,治疗组疗效优于对照组。(5)血清尿素氮:治疗后,治疗组血清尿素氮平均值为9.06±2.07,对照组平均值为10.52±2.32,两组结果经过比较,P0.05,差异有统计学意义,治疗组疗效优于对照组。(6)24小时尿蛋白定量:治疗后,治疗组24小时尿蛋白定量平均值为5.75±0.95,对照组平均值为6.31±1.09,两组结果经过比较,P0.05,差异有统计学意义,治疗组疗效优于对照组。(7)中医症候积分:治疗后,治疗组中医症候积分平均值为6.60±2.61,对照组平均值为9.00±5.05,两组结果经过比较,P0.05,差异有统计学意义,治疗组疗效优于对照组。结论:(1)益肾补脾方可有效改善慢性肾脏病CKD3期脾肾气虚患者钙磷代谢异常的指标。(2)益肾补脾方在有效改善CKD3期脾肾气虚证患者钙磷代谢的同时还可延缓肾功能的进展。
[Abstract]:Objective: to observe the effect of Yishen Bupi recipe on abnormal calcium and phosphorus metabolism in CKD3 patients with deficiency of spleen and kidney qi. Methods: from October 2014 to October 2016, 60 patients with spleen and kidney qi deficiency in stage 3 of chronic kidney disease were selected from the Department of Nephrology, first affiliated Hospital of Guangxi University of traditional Chinese Medicine. The control group was randomly divided into control group and treatment group. The control group was given basic treatment plus calcium carbonate D3. The treatment group was treated with Yishen Bupi recipe on the basis of control group for 6 months. Serum calcium, phosphorus, total parathyroid hormone, 24 hour urinary protein of renal function, quantitative score of TCM symptoms and so on were observed, and the safety was evaluated. To provide clinical basis for the treatment of chronic kidney disease in CKD3 stage spleen and kidney Qi deficiency calcium phosphorus methodicity. Results: after 6 months of clinical study, the results were as follows: (1) Serum calcium: after treatment, the average value of serum calcium in the treatment group was 2.13 卤0.19, and the average value in the control group was 1.92 卤0.13. The results of the two groups were compared with each other (P 0.05). (2) Serum phosphorus: after treatment, the average value of serum phosphorus in the treatment group was 1.34 卤0.02, and the average value in the control group was 1.45 卤0.03. (3) after the treatment of (iPTH):, the average iPTH of the treatment group was 72.16 卤6.27, and the average value of the control group was 76.12 卤6.43.The results of the two groups were compared with that of the control group (P 0.05). (4) after treatment, the mean value of serum creatinine was 123.02 卤17.95 in the treatment group and 132.28 卤29.22 in the control group. The difference between the two groups was statistically significant. (5) the serum urea nitrogen in the treatment group was better than that in the control group. The average value of serum urea nitrogen was 9.06 卤2.07 in the treatment group and 10.52 卤2.32 in the control group. There was a significant difference between the two groups. (6) the effect of the treatment group was better than that of the control group. (6) 24 hours urine protein quantification: after treatment, there was no significant difference between the two groups. The quantitative average value of urinary protein in the treatment group was 5.75 卤0.95, and the average value in the control group was 6.31 卤1.09.The results of the two groups were compared with that of the control group (P 0.05), the difference was statistically significant. (7) the TCM symptom score of the treatment group was better than that of the control group. (7) after treatment, there was no significant difference between the two groups. The average score of TCM symptom in the treatment group was 6.60 卤2.61, and the average value in the control group was 9.00 卤5.05. The difference between the two groups was statistically significant, and the curative effect of the treatment group was better than that of the control group. Conclusion: (1) Yishen Bupi decoction can effectively improve the indexes of abnormal calcium and phosphorus metabolism in CKD3 patients with deficiency of spleen and kidney qi, and (2) Yishen Bupi recipe can effectively improve calcium and phosphorus metabolism in patients with spleen and kidney qi deficiency syndrome in CKD3 stage and delay the progress of renal function at the same time.
【学位授予单位】：广西中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R277.5
本文编号：2221866
[Abstract]:Objective: to observe the effect of Yishen Bupi recipe on abnormal calcium and phosphorus metabolism in CKD3 patients with deficiency of spleen and kidney qi. Methods: from October 2014 to October 2016, 60 patients with spleen and kidney qi deficiency in stage 3 of chronic kidney disease were selected from the Department of Nephrology, first affiliated Hospital of Guangxi University of traditional Chinese Medicine. The control group was randomly divided into control group and treatment group. The control group was given basic treatment plus calcium carbonate D3. The treatment group was treated with Yishen Bupi recipe on the basis of control group for 6 months. Serum calcium, phosphorus, total parathyroid hormone, 24 hour urinary protein of renal function, quantitative score of TCM symptoms and so on were observed, and the safety was evaluated. To provide clinical basis for the treatment of chronic kidney disease in CKD3 stage spleen and kidney Qi deficiency calcium phosphorus methodicity. Results: after 6 months of clinical study, the results were as follows: (1) Serum calcium: after treatment, the average value of serum calcium in the treatment group was 2.13 卤0.19, and the average value in the control group was 1.92 卤0.13. The results of the two groups were compared with each other (P 0.05). (2) Serum phosphorus: after treatment, the average value of serum phosphorus in the treatment group was 1.34 卤0.02, and the average value in the control group was 1.45 卤0.03. (3) after the treatment of (iPTH):, the average iPTH of the treatment group was 72.16 卤6.27, and the average value of the control group was 76.12 卤6.43.The results of the two groups were compared with that of the control group (P 0.05). (4) after treatment, the mean value of serum creatinine was 123.02 卤17.95 in the treatment group and 132.28 卤29.22 in the control group. The difference between the two groups was statistically significant. (5) the serum urea nitrogen in the treatment group was better than that in the control group. The average value of serum urea nitrogen was 9.06 卤2.07 in the treatment group and 10.52 卤2.32 in the control group. There was a significant difference between the two groups. (6) the effect of the treatment group was better than that of the control group. (6) 24 hours urine protein quantification: after treatment, there was no significant difference between the two groups. The quantitative average value of urinary protein in the treatment group was 5.75 卤0.95, and the average value in the control group was 6.31 卤1.09.The results of the two groups were compared with that of the control group (P 0.05), the difference was statistically significant. (7) the TCM symptom score of the treatment group was better than that of the control group. (7) after treatment, there was no significant difference between the two groups. The average score of TCM symptom in the treatment group was 6.60 卤2.61, and the average value in the control group was 9.00 卤5.05. The difference between the two groups was statistically significant, and the curative effect of the treatment group was better than that of the control group. Conclusion: (1) Yishen Bupi decoction can effectively improve the indexes of abnormal calcium and phosphorus metabolism in CKD3 patients with deficiency of spleen and kidney qi, and (2) Yishen Bupi recipe can effectively improve calcium and phosphorus metabolism in patients with spleen and kidney qi deficiency syndrome in CKD3 stage and delay the progress of renal function at the same time.
【学位授予单位】：广西中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R277.5
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