十味香鹿胶囊治疗乳腺增生病（肝郁兼痰凝证）的临床观察

发布时间：2018-09-07 13:09

【摘要】：研究目的:通过观察乳腺疼痛,乳腺肿块以及中医证侯积分的治疗前后的变化借以评测十味香鹿胶囊治疗乳腺增生病(肝郁兼痰凝证)的有效性及安全性。方法:选取病例为2016年07月-2017年03月黑龙江中医药大学附属第一医院外二科门诊符合乳腺增生病且中医辨证属于肝郁兼痰凝门诊患者48例,并将其随机分为治疗组(十味香鹿胶囊组)与对照组(乳康片组),每组入组患者各24例。治疗组给与十味香鹿胶囊每次五粒,3次/日、口服,服药时间为两个月经周期,月经来潮时开始服药。对照组给与乳康片3片/次,3次/日、口服,服药时间为两个月经周期。观察两个月经周期后各项观察指标的变化。结果:1.有效率:治疗组(十味香鹿胶囊组)的总体有效率为91.70%,对照组(乳康片组)的总体有效率为87.50%,治疗组(十味香鹿胶囊组)与对照组(乳康片组)在有效率上无明显差异。2.中医证侯积分:两组治疗前后中医证侯积分对比有明显差异(P0.05),治疗后两组患者积分对比无差异(P0.05),3.乳房肿块长径:两组治疗前后有差异(P0.05),两组乳房肿块治疗后比较无显著差异(P0.05).4.乳腺疼痛天数:两组治疗前后比较有差异(P0.05),两组治疗后组间比较无明显差异(P0.05)。5.乳腺疼痛积分:两组治疗前组间比较无明显差异,治疗前后组内比较有差异(P0.05),治疗后组间比较有差异(P0.05)。治疗组(十味香鹿胶囊组)优于对照组(乳康片组)。6.安全性指标:治疗前后无显著变化。结论:十味香鹿胶囊对于治疗肝郁兼痰凝型乳腺增生有较好效果,在综合疗效上与中成药乳康片组相比无显著差异。十味香鹿胶囊能明显的缓解乳房疼痛(疗效优于乳康片),缩短乳房疼痛时间,缩小乳腺肿块,能明显改善患者的中医证侯,并且无明显毒副作用。
[Abstract]:Objective: to evaluate the efficacy and safety of Shiwei Xianglu capsule in the treatment of hyperplasia of mammary gland (liver depression and phlegm coagulation syndrome) by observing the changes of breast pain, breast mass and TCM syndromes before and after treatment. Methods: from July 2016 to March 2017, 48 patients with liver depression and phlegm coagulation were enrolled in the outpatient department of the first affiliated Hospital of Heilongjiang University of traditional Chinese Medicine. They were randomly divided into treatment group (Shiwei Xianglu capsule group) and control group (Rukang tablet group). In the treatment group, five tablets of Shiwei Xianglu capsule were given three times a day for two menstrual cycles. The control group was given three tablets of Rukang tablets every 3 times a day for two menstrual cycles. Observe the change of observation indexes after two menstrual cycles. The result is 1: 1. The total effective rate was 91.70 in the treatment group (Shiwei Xianglu capsule group) and 87.50 in the control group (Rukang tablet group). There was no significant difference in the effective rate between the treatment group (Shiwei Xianglu capsule group) and the control group (Rukang tablet group). TCM syndromes score: the two groups before and after treatment of TCM syndromes scores were significantly different (P0.05), after treatment there was no difference between the two groups (P0.05). Breast mass length: two groups before and after treatment there was a difference (P0.05), two groups of breast masses after treatment there was no significant difference (P0.05). 4. Days of breast pain: there was significant difference between the two groups before and after treatment (P0.05), but there was no significant difference between the two groups after treatment (P0.05) .5. Breast pain score: there was no significant difference between the two groups before and after treatment, there were differences before and after treatment (P0.05). The treatment group (Shiwei Xianglu capsule group) was superior to the control group (Rukang tablet group) .6. Safety index: there was no significant change before and after treatment. Conclusion: Shiwei Xianglu capsule has good effect in treating liver depression and phlegm coagulation type hyperplasia of mammary gland. Shiwei Xianglu capsule can obviously relieve breast pain (curative effect is better than Rukang tablet), shorten the time of breast pain, reduce breast mass, can obviously improve the TCM syndrome of patients, and have no obvious side effects.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R269

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