枳实通降颗粒对结直肠肿瘤患者术后胃肠功能恢复及术后早期炎性肠梗阻防治作用的双中心前瞻性研究
发布时间：2018-09-07 20:02
【摘要】：目的评价枳实通降颗粒对结直肠肿瘤患者术后胃肠功能恢复及术后早期炎性肠梗阻防治的有效性及安全性。方法采用多中心前瞻性随机双盲对照方法,将结直肠肿瘤手术患者197例分为试验组98例,对照组99例。两组患者围手术期均给予常规治疗,试验组于术后6~12 h开始少量多次口服或经胃管给予枳实通降颗粒(制成50 ml药液),每日1剂。对照组仅口服等量安慰剂。记录患者肠鸣音恢复时间、首次排气时间、首次排便时间、首次进食固体食物时间、住院天数、肠梗阻发生情况,并记录不良反应及并发症发生情况,观察安全性指标变化。结果试验组术后肠鸣音恢复时间、首次排气时间、首次排便时间及首次进食固体食物时间均较对照组明显缩短(P0.01)。对照组6例发生术后早期炎性肠梗阻,试验组4例。试验组平均住院时间(14.00±0.82)天,显著短于对照组的(19.33±3.98)天(P0.05)。两组并发症及肝肾功能异常发生情况比较,差异均无统计学意义(P0.05)。术后第5天试验组降钙素原下降较对照组明显(P0.05)。结论枳实通降颗粒可促进结直肠肿瘤胃肠道手术后患者胃肠功能恢复,并对术后早期炎性肠梗阻有一定的防治作用,且安全性好。
[Abstract]:Objective to evaluate the efficacy and safety of Zhishi Tongjiang granule in the prevention and treatment of postoperative gastrointestinal function and early postoperative inflammatory intestinal obstruction in patients with colorectal cancer. Methods 197 patients undergoing colorectal tumor surgery were divided into two groups (n = 98) and control group (n = 99). Patients in both groups were given routine treatment during the perioperative period. In the experimental group, a small amount of oral or gastric tube administration of Aurantium aurantii Tongjiang granules (made into 50 ml solution) was given at 6 and 12 hours after operation, once a day. The control group only took the same amount of placebo. The recovery time, the first exhaust time, the first defecation time, the first time of eating solid food, the days of hospitalization and the incidence of intestinal obstruction were recorded. The adverse reactions and complications were recorded, and the changes of safety indexes were observed. Results compared with the control group, the recovery time, the first exhaust time, the first defecation time and the first time of eating solid food in the experimental group were significantly shorter than those in the control group (P0.01). Early postoperative inflammatory intestinal obstruction occurred in 6 cases in the control group and 4 cases in the experimental group. The average hospital stay in the trial group was (14.00 卤0.82) days, significantly shorter than that in the control group (19.33 卤3.98) days (P0.05). There was no significant difference in the incidence of complications and abnormal liver and kidney function between the two groups (P0.05). The level of procalcitonin in the trial group was significantly lower than that in the control group on the 5th day after operation (P0.05). Conclusion Zhishitongjiang granule can promote the recovery of gastrointestinal function in patients with colorectal cancer after gastrointestinal operation, and has a certain preventive and therapeutic effect on early postoperative inflammatory intestinal obstruction, and has good safety.
【作者单位】： 湖南中医药大学;湖南省中医院;湖南省肿瘤医院;
【分类号】：R273
本文编号：2229275
[Abstract]:Objective to evaluate the efficacy and safety of Zhishi Tongjiang granule in the prevention and treatment of postoperative gastrointestinal function and early postoperative inflammatory intestinal obstruction in patients with colorectal cancer. Methods 197 patients undergoing colorectal tumor surgery were divided into two groups (n = 98) and control group (n = 99). Patients in both groups were given routine treatment during the perioperative period. In the experimental group, a small amount of oral or gastric tube administration of Aurantium aurantii Tongjiang granules (made into 50 ml solution) was given at 6 and 12 hours after operation, once a day. The control group only took the same amount of placebo. The recovery time, the first exhaust time, the first defecation time, the first time of eating solid food, the days of hospitalization and the incidence of intestinal obstruction were recorded. The adverse reactions and complications were recorded, and the changes of safety indexes were observed. Results compared with the control group, the recovery time, the first exhaust time, the first defecation time and the first time of eating solid food in the experimental group were significantly shorter than those in the control group (P0.01). Early postoperative inflammatory intestinal obstruction occurred in 6 cases in the control group and 4 cases in the experimental group. The average hospital stay in the trial group was (14.00 卤0.82) days, significantly shorter than that in the control group (19.33 卤3.98) days (P0.05). There was no significant difference in the incidence of complications and abnormal liver and kidney function between the two groups (P0.05). The level of procalcitonin in the trial group was significantly lower than that in the control group on the 5th day after operation (P0.05). Conclusion Zhishitongjiang granule can promote the recovery of gastrointestinal function in patients with colorectal cancer after gastrointestinal operation, and has a certain preventive and therapeutic effect on early postoperative inflammatory intestinal obstruction, and has good safety.
【作者单位】： 湖南中医药大学;湖南省中医院;湖南省肿瘤医院;
【分类号】：R273
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，本文编号：2229275
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