注射用益气复脉（冻干粉）治疗慢性心力衰竭（气阴两虚型）的临床研究

发布时间：2018-09-08 06:29

【摘要】：目的:通过对注射用益气复脉(冻干粉)治疗慢性心力衰竭(Chronic Heart Failure,CHF)(气阴两虚型)30例的临床研究,进而观察注射用益气复脉治疗慢性心力衰竭(气阴两虚型)的临床疗效并研讨其作用机理。方法:按照纳入和排除标准选取山东中医药大学第一附属医院(山东省中医院)综合内科住院病人60例,随机分为试验组、对照组各30例。两组患者的一般情况无统计学差异。对照组采用西药常规综合治疗,治疗组在西药常规综合治疗基础上加用注射用益气复脉(冻干粉)(3.9g/次),1次/日,用5%葡萄糖注射液(GS)或0.9%生理盐水(NS)250ml稀释后通过静脉滴注,静滴速度为40±5滴/分钟,疗程为14天。系统观察并对比两组患者治疗前后的中医症候积分、心衰的症状计分、明尼苏达心衰生活质量量表、BNP前体(NT-proBNP)、心功能分级、心脏彩超、6分钟步行试验等指标的变化,并检测两组患者治疗前后血常规、肝肾功能等指标的变化,从而评价其疗效、安全性并探讨其作用机理。结果:经过2周治疗后,对比两组临床疗效,试验组在心衰症状计分判定方面、中医症候积分对照、明尼苏达心力衰竭生活质量量表对比、BNP前体(NT-proBNP)对比、心功能分级对比、心脏彩超对比、6分钟步行试验对比等方面试验组均优于对照组(P0.05)。总体比较,试验组各项疗效结果均优于对照组。血常规、肝肾功能等安全性检测指标方面,两组患者治疗前后无明显变化(P0.05),应用安全。结论:注射用益气复脉(冻干粉)治疗慢性心力衰竭(气阴两虚型)在改进心衰症状计分、中医症候积分、明尼苏达心衰生活质量量表、BNP前体(NT-proBNP)、心功能分级、心脏彩超、6分钟步行试验等方面均有显著疗效,两组治疗方案对血常规、肝肾功能等无明显影响,提示注射用益气复脉(冻干粉)治疗慢性心力衰竭(气阴两虚型)有确切疗效。
[Abstract]:Objective: to study 30 cases of chronic heart failure (Chronic Heart Failure,CHF) treated with Yiqi Fumai (freeze-dried powder) for injection (deficiency of Qi and Yin). Then the clinical effect and mechanism of the treatment of chronic heart failure (deficiency of qi and yin) with invigorating qi and nourishing pulse for injection were observed. Methods: according to the criteria of inclusion and exclusion, 60 inpatients in general internal medicine of the first affiliated Hospital of Shandong University of traditional Chinese Medicine (Shandong Provincial Hospital of traditional Chinese Medicine) were randomly divided into experimental group (n = 30) and control group (n = 30). There was no statistical difference in the general situation between the two groups. The control group was treated with routine western medicine combined therapy, the treatment group was treated with intravenous drip of 5% glucose injection (GS) or 0.9% normal saline (NS) 250ml after injection of Yiqi Fumai (3.9g/ times) once a day on the basis of routine western medicine comprehensive treatment, the control group was treated with routine western medicine combined therapy, and the treatment group was treated with injection of Yiqi Fumai (freeze-dried powder) (3.9g/) once a day. The rate of intravenous drip was 40 卤5 drops per minute, and the course of treatment was 14 days. The changes of TCM symptom score, symptom score of heart failure, Minnesota Heart failure quality of Life scale (NT-proBNP), cardiac function grading and 6 minute walking test were observed and compared between the two groups before and after treatment. The changes of blood routine, liver and kidney function before and after treatment were detected to evaluate the efficacy, safety and mechanism of treatment. Results: after 2 weeks of treatment, the clinical efficacy was compared between the two groups. In the trial group, the score of symptoms of heart failure, the score of TCM symptom, the quality of life scale of Minnesota heart failure were compared with the comparison of NT-proBNP and cardiac function grading. Compared with the control group, the heart color Doppler ultrasound and 6 minutes walking test were better than the control group (P0.05). Compared with the control group, the curative effect of the test group was better than that of the control group. Blood routine, liver and kidney function and other safety indicators, the two groups of patients before and after treatment did not change significantly (P0.05), the application of safety. Conclusion: the treatment of chronic heart failure (deficiency of qi and yin) with Yiqi Fumai (freeze-dried powder) for injection can improve the score of symptoms of heart failure, the integral of TCM symptoms, the quality of life (NT-proBNP) of Minnesota Heart failure scale, and the classification of cardiac function. There was no significant effect on blood routine, liver and kidney function in the two groups. It is suggested that the treatment of chronic heart failure (deficiency of qi and yin) by injection of tonifying qi and tonifying pulse (freeze-dried powder) is effective.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

【相似文献】