辛通颗粒治疗小儿腺样体肥大风热犯肺型的临床研究

发布时间：2018-09-10 12:15

【摘要】：目的:观察辛通颗粒治疗风热犯肺型小儿腺样体肥大的临床疗效,评估该方的有效性。同时观察患儿服药过程中是否出现不良反应,初步评估该方药物的安全性。方法:选取符合纳入标准的病患72例,以随机单盲法平均分为观察组和对照组,观察组口服辛通颗粒,对照组外用糠酸莫米松鼻喷雾剂,两组均连续治疗15天,综合评估两组患儿治疗前后症状、体征及辅助检查等的变化,统计分析,评估临床疗效。结果:选取的72例患者中,有12例(被剔除和脱落)未被纳入最终研究,对试验前两组患者的各项资料经对比后,差异无统计学意义,具有可比性,可以开始临床研究。(1)连续15天治疗后两组患儿的证候积分均低于治疗前,前后积分对比,差别均有统计学意义(P0.05),提示观察组、对照组的治疗均为有效;(2)观察组和对照组的总有效率分别为90%、70%,差别有统计学意义(P0.05),提示观察组的总有效率优于对照组;(3)治疗后观察组证候总积分、主要积分、次要积分均低于对照组,差别有统计学意义(P0.05),提示在改善总体证候、主要证候、次要证候方面,观察组的疗效优于对照组;(4)两组患儿治疗后,打鼾、张口呼吸、鼻塞、咽部异物感、咽后壁淋巴滤泡增生、大便干结单项积分差别有统计学意义(P0.05),提示观察组在改善打鼾、张口呼吸、鼻塞、咽部异物感、咽后壁淋巴滤泡增生、大便干结方面的疗效优于对照组;(5)两组患儿治疗后,扁桃体肿大单项积分差别无统计学意义(P0.05),提示在改善扁桃体肿大方面两组疗效相当;(6)两组患儿治疗期间均未出现不良反应。结论:通过对辛通颗粒治疗小儿腺样体肥大风热犯肺型的临床研究,表明该方治疗小儿腺样体肥大风热犯肺型疗效肯定,且未发现不良反应,口服安全有效,值得进一步临床推广应用。
[Abstract]:Aim: to observe the clinical effect of Xintong granule on adenoid hypertrophy in children with wind-heat invasion of lung type and to evaluate the effectiveness of Xintong granule. At the same time, the adverse reactions were observed and the safety of the prescription was preliminarily evaluated. Methods: a total of 72 patients who met the inclusion criteria were randomly divided into two groups: the observation group and the control group. The observation group was treated with xintong granule and the control group was treated with momethasone furoate nasal spray for 15 days. The changes of symptoms, signs and adjuvant examinations before and after treatment were comprehensively evaluated, and the clinical efficacy was evaluated by statistical analysis. Results: of the 72 selected patients, 12 (excluded and dropped) were not included in the final study. After comparing the data of the two groups before the trial, the difference was not statistically significant and comparable. Clinical study can be started. (1) after 15 consecutive days of treatment, the syndrome scores of the two groups were lower than those before treatment, the difference between the scores before and after treatment was statistically significant (P0.05), indicating that the observation group, The treatment of the control group is effective; (2) the total effective rate of the observation group and the control group is 90%, the difference is statistically significant (P0.05), indicating that the total effective rate of the observation group is better than that of the control group; (3) the total syndrome integral, the main integral of the observation group after treatment. Secondary scores were lower than the control group, the difference was statistically significant (P0.05), suggesting that in improving the overall syndrome, main syndrome, secondary syndrome, the observation group is better than the control group; (4) after treatment, the two groups of children snoring, open mouth breathing, nasal obstruction, Foreign body sensation in pharynx, hyperplasia of lymphoid follicle in posterior wall of pharynx, single score of dry knot of stool were significantly different (P0.05), indicating that the observation group was improving snoring, opening mouth breathing, nasal obstruction, feeling of foreign body in pharynx, hyperplasia of lymphoid follicle in posterior wall of pharynx, The curative effect of stool dry knot was better than that of the control group; (5) after treatment, there was no significant difference in the single score of tonsil enlargement between the two groups (P0.05), indicating that the two groups had the same curative effect in improving tonsillar swelling; (6) there were no adverse reactions in both groups during the treatment period. Conclusion: the clinical study on the treatment of children adenoid hypertrophy with wind-heat invading lung type by Xintong granule shows that this prescription has definite curative effect on children with adenoid hypertrophy and wind-heat invading lung type, and no adverse reaction has been found, and oral administration is safe and effective. It is worthy of further clinical application.
【学位授予单位】：云南中医学院
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R276.1

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