补肾调肝方对非肥胖型多囊卵巢综合征患者糖脂代谢的影响

发布时间：2018-09-11 21:50

【摘要】：目的观察补肾调肝方对非肥胖型多囊卵巢综合征(polycystic ovary syndrome,PCOS)糖脂代谢的影响。方法将60例肾虚肝郁型非肥胖型PCOS(BMI25)患者,随机分为治疗组和对照组,每组30例。治疗组采用补肾调肝方(毓麟珠合柴胡舒肝散)每日1剂,早晚分服;对照组选用二甲双胍片(1 000 mg/次),每日2次,早晚随餐口服;两组疗程均为3个月。观察治疗前后空腹血糖(fasting plasma glucose,FPG)、空腹胰岛素(fasting insulin,FINS),稳态胰岛素抵抗指数(homeostasis model assessment-insulin resistance,HOMA-IR)、TC、TG、体重指数(body mass index,BMI)、腰臀比(waist hip ratio,WHR)、黄体生成素(luteinizing hormone,LH)、卵泡雌激素(follicle stimulating hormone,FSH)、LH/FSH以及游离睾酮(free testosterone,T)水平变化。结果与本组治疗前比较,对照组FPG、FINS、LH/FSH及BMI下降(P0.05,P0.01),治疗组FPG、TC、LH、LH/FSH、WHR及BMI均下降(P0.05,P0.01)。与对照组比较,治疗组WHR、BMI、FINS、LH水平差异有统计学意义(P0.05)。结论非肥胖型PCOS患者不以全身胰岛素抵抗为主要表现;补肾调肝方通过降低LH、LH/FSH,改善糖脂代谢情况,从而对非肥胖型PCOS起到治疗作用。
[Abstract]:Objective to observe the effect of Bushen Tiaogan recipe on glucose and lipid metabolism in non-obese polycystic ovary syndrome (polycystic ovary syndrome,PCOS). Methods 60 cases of non-obese PCOS (BMI25) with kidney deficiency and liver depression were randomly divided into treatment group and control group with 30 cases in each group. The treatment group was treated with Bushen Tiaogan decoction (Yulin Zhuhe and Chaihu Shugan Powder), and the control group was treated with metformin tablet (1 000 mg/) twice a day, with meal in the morning and evening. The course of treatment in both groups was 3 months. Fasting plasma glucose (fasting plasma glucose,FPG), fasting insulin (fasting insulin,FINS), steady-state insulin resistance index (homeostasis model assessment-insulin resistance,HOMA-IR), body mass index (body mass index,BMI), waist to hip ratio (waist hip ratio,WHR), luteinizing hormone (luteinizing hormone,LH), follicular estrogen (follicle stimulating hormone,FSH (follicle stimulating hormone,FSH) and free testosterone (free testosterone,T) were observed before and after treatment. Results compared with before treatment, FPG,FINS,LH/FSH and BMI in control group were decreased (P0.05, P0.01), FPG,TC,LH,LH/FSH,WHR and BMI in treatment group were both decreased (P0.05, P0.01). Compared with the control group, WHR,BMI,FINS,LH levels in the treatment group were significantly different (P0.05). Conclusion Bushen Tiaogan recipe can improve glucose and lipid metabolism by decreasing LH,LH/FSH, in patients with non-obese PCOS, so it has therapeutic effect on non-obese PCOS.
【作者单位】：浙江省中西医结合医院生殖医学科;杭州师范大学生命与环境科学学院;
【基金】：国家名老中医工作室科研项目浙江省中医药管理局青年基金资助项目(No.2010ZQ012) 杭州市科学技术委员会重点专病专科项目(No.20150733Q38) 杭州市科技局课题资助项目(No.20100733Q24)
【分类号】：R271.9

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