桂枝汤治疗胆碱能性荨麻疹患者的临床研究
发布时间：2018-09-17 15:01
【摘要】：目的通过桂枝汤治疗胆碱能性荨麻疹(Cholinergic urticaria,Ch U)患者临床症状的疗效观察,同时检测Ch U患者自体血清皮肤试验、自体汗液皮肤试验和血清中总Ig E水平的变化,对桂枝汤治疗胆碱能性荨麻疹的病理机制进行初步探讨。方法1.临床资料本组临床资料均来自于武汉周边某部队军人。2016年3月至2017年1月共我们收集胆碱能性荨麻疹合格调查问卷836份,其中符合胆碱能性荨麻疹诊断标准的患者69人,愿意全程参与本次实验的胆碱能性荨麻疹患者有20人。2.治疗和方法使用中药(口服桂枝汤每日1剂,每次150ml,早晚各1次)治疗胆碱能性荨麻疹患者30天,观察自体血清皮肤试验、自体汗液皮肤试验和血清中总Ig E的水平在口服桂枝汤的过程中,其治疗前、治疗15天、治疗30天后的变化。结果1.临床研究方面(1)经过15天的治疗后,观察临床疗效数据显示:15天治疗的总有效率为40%。经过30天的治疗后,观察临床疗效数据显示:30天治疗的总有效率为90%。治疗后15天症状积分下降指数(SSRI)与治疗后30天SSRI比较,差异有显著统计学意义(P0.05),治疗后30天SSRI较治疗后15天SSRI显著增加。(2)治疗后30天症状评分与治疗前症状评分相比,结果有显著统计学差异(P0.01),而治疗后15天症状评分与治疗前症状评分相比,结果无明显统计学差异(P0.05)。2.实验室研究方面(1)桂枝汤治疗胆碱能性荨麻疹患者,治疗前与治疗30天后,自体汗液皮肤试验结果有显著统计学差异(P0.01),而自体血清皮肤试验治疗前与治疗30天后相比,其结果无明显统计学差异(P0.05)。(2)治疗后30天的总Ig E水平与治疗前的总Ig E水平相比,结果有显著统计学差异(P0.05),而治疗后15天的总Ig E水平与治疗前总Ig E水平相比,结果无明显统计学差异(P0.05)。结论桂枝汤治疗胆碱能性荨麻疹有较好的临床疗效,桂枝汤能够调节胆碱能性荨麻疹患者出汗情况,减少风团的产生,减轻患者的临床症状,降低患者血清总Ig E水平,调节机体的免疫功能,从而提高胆碱能性荨麻疹患者的生活质量。
[Abstract]:Objective to observe the efficacy of Guizhi decoction in treating cholinergic urticaria (Cholinergic urticaria,Ch U), and to detect the changes of serum autogenous skin test, autologous sweat skin test and serum total Ig E level in patients with Ch U. The pathological mechanism of Guizhi decoction in the treatment of cholinergic urticaria was discussed. Method 1. From March 2016 to January 2017, we collected 836 qualified questionnaires for cholinergic urticaria, 69 of which met the diagnostic criteria of cholinergic urticaria. Twenty patients with cholinergic urticaria were willing to participate in the study. To treat cholinergic urticaria patients with cholinergic urticaria by traditional Chinese medicine (oral Guizhi decoction, 150 ml / day, 1 time in the morning and evening) for 30 days, and observe the skin test of autogenous serum. Autologous perspiration skin test and serum total Ig E levels in the course of oral administration of Guizhi decoction, the changes were observed before, 15 days and 30 days after treatment. Result 1. In clinical studies (1) after 15 days of treatment, the observation of clinical efficacy data showed that the total effective rate of 15 days treatment was 40%. After 30 days of treatment, the clinical efficacy data showed that the total effective rate of 30 days treatment was 90. The decrease index of symptom score (SSRI) on day 15 after treatment was significantly higher than that on day 30 after treatment (P0.05), and SSRI on day 30 after treatment was significantly higher than that on day 15 after treatment. (2) symptom score at day 30 after treatment was significantly higher than that at day 30 after treatment. Results there was significant statistical difference (P0.01), but there was no significant difference between the symptom score of 15 days after treatment and the pre-treatment symptom score (P0.05). 2. In laboratory studies, (1) there was a significant difference in the results of autologous sweat skin test before and after 30 days of treatment in patients with cholinergic urticaria treated with Guizhi decoction (P0.01), but there was a significant difference between before and after 30 days of treatment with the autologous serum skin test. The results showed that there was no significant difference (P0.05). (2) between the total Ig E level 30 days after treatment and the total Ig E level before treatment (P0.05), while the total Ig E level 15 days after treatment was compared with the total Ig E level before treatment. Results there was no significant statistical difference (P0.05). Conclusion Guizhi decoction has a good clinical effect on cholinergic urticaria. Guizhi decoction can regulate the sweating condition of cholinergic urticaria patients, reduce the formation of wind mass, alleviate the clinical symptoms of patients, and reduce the serum total Ig E level of patients with cholinergic urticaria. Adjusts the body's immune function, thus improves the cholinergic urticaria patient's quality of life.
【学位授予单位】：湖北中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R275.9
本文编号：2246280
[Abstract]:Objective to observe the efficacy of Guizhi decoction in treating cholinergic urticaria (Cholinergic urticaria,Ch U), and to detect the changes of serum autogenous skin test, autologous sweat skin test and serum total Ig E level in patients with Ch U. The pathological mechanism of Guizhi decoction in the treatment of cholinergic urticaria was discussed. Method 1. From March 2016 to January 2017, we collected 836 qualified questionnaires for cholinergic urticaria, 69 of which met the diagnostic criteria of cholinergic urticaria. Twenty patients with cholinergic urticaria were willing to participate in the study. To treat cholinergic urticaria patients with cholinergic urticaria by traditional Chinese medicine (oral Guizhi decoction, 150 ml / day, 1 time in the morning and evening) for 30 days, and observe the skin test of autogenous serum. Autologous perspiration skin test and serum total Ig E levels in the course of oral administration of Guizhi decoction, the changes were observed before, 15 days and 30 days after treatment. Result 1. In clinical studies (1) after 15 days of treatment, the observation of clinical efficacy data showed that the total effective rate of 15 days treatment was 40%. After 30 days of treatment, the clinical efficacy data showed that the total effective rate of 30 days treatment was 90. The decrease index of symptom score (SSRI) on day 15 after treatment was significantly higher than that on day 30 after treatment (P0.05), and SSRI on day 30 after treatment was significantly higher than that on day 15 after treatment. (2) symptom score at day 30 after treatment was significantly higher than that at day 30 after treatment. Results there was significant statistical difference (P0.01), but there was no significant difference between the symptom score of 15 days after treatment and the pre-treatment symptom score (P0.05). 2. In laboratory studies, (1) there was a significant difference in the results of autologous sweat skin test before and after 30 days of treatment in patients with cholinergic urticaria treated with Guizhi decoction (P0.01), but there was a significant difference between before and after 30 days of treatment with the autologous serum skin test. The results showed that there was no significant difference (P0.05). (2) between the total Ig E level 30 days after treatment and the total Ig E level before treatment (P0.05), while the total Ig E level 15 days after treatment was compared with the total Ig E level before treatment. Results there was no significant statistical difference (P0.05). Conclusion Guizhi decoction has a good clinical effect on cholinergic urticaria. Guizhi decoction can regulate the sweating condition of cholinergic urticaria patients, reduce the formation of wind mass, alleviate the clinical symptoms of patients, and reduce the serum total Ig E level of patients with cholinergic urticaria. Adjusts the body's immune function, thus improves the cholinergic urticaria patient's quality of life.
【学位授予单位】：湖北中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R275.9
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