川芎清脑颗粒治疗偏头痛（风湿蒙蔽，瘀血阻滞证）57例临床研究

发布时间：2018-09-17 16:41

【摘要】：目的:观察川芎清脑颗粒治疗偏头痛(风湿蒙蔽,瘀血阻滞证)临床疗效特点。方法:采用自身对照的临床研究方法,疗程为2周,停药后随访2个月。川芎清脑颗粒由济川药业集团有限公司提供(国药准字Z20060177),10g/袋。用法:冲服,1袋/次,每日3次。观察川芎清脑颗粒治疗偏头痛(风湿蒙蔽,瘀血阻滞证)患者的发作次数,头痛发作程度,中医症状等方面的改善情况。结果:本研究纳入60例偏头痛患者,有效病例57例。经过川芎清脑颗粒治疗2周后,头痛发作次数明显减少,治疗2周分别与治疗1周和治疗前比较(P0.05),头痛发作程度(VAS评分)及头痛发作天数均低于治疗前水平,且差异有统计学意义(P0.05);评价期内平均药物起效时间为3.285小时,在治疗的第5天起,服药后累计起效百分比50%。患者服用止痛药次数减少,治疗第2周患者服用止痛药次数低于治疗第1周(P=0.0460.05)。中医症状得到明显改善,治疗2周与治疗前比较分析显示:患者各项中医症状评分前后改善差异均有统计学意义(P0.05)。中医症状总计分前后改善差异有统计学意义(P0.05)。随访期内,患者中医症状量表总体疗效分析,治疗2周有效率高于治疗1周,差异有统计学意义(P=0.0430.05)。结论:川芎清脑颗粒可显著减轻患者头痛发作程度,减少头痛发作次数,改善中医症状,且无明显不良反应,安全性好,值得在临床中推广。
[Abstract]:Objective: to observe the clinical efficacy of Chuanxiong Qingnao granule in treating migraine. Methods: a self-controlled clinical study was carried out for 2 weeks, followed up for 2 months. Chuanxiong Qingnao granule is supplied by Jichuan Pharmaceutical Group Co., Ltd. (Z20060177) 10 g / bag. Usage: 1 bag / time, 3 times a day. To observe the effect of Chuanxiong Qingnao granule on the treatment of migraine (rheumatism masking, blood stasis block) patients' attack times, the degree of headache attack, the symptoms of traditional Chinese medicine and so on. Results: 60 migraine patients and 57 effective cases were included in this study. After being treated with Chuanxiong Qingnao granule for 2 weeks, the frequency of headache attack was significantly reduced, the two weeks of treatment were compared with the treatment of 1 week and before treatment (P0.05), the degree of headache attack (VAS score) and the days of headache attack were lower than those before treatment. And the difference was statistically significant (P0.05); the average effective time was 3.285 hours in the evaluation period, and the cumulative effective percentage was 50% after the treatment on the 5th day. The number of analgesics was lower in the second week than that in the first week (P0.0460.05). Traditional Chinese medicine symptoms were significantly improved, compared with the treatment before 2 weeks analysis showed that: patients before and after the improvement of TCM symptoms were statistically significant (P0.05). There was significant difference in the improvement of TCM symptom before and after the total score (P0.05). During the follow-up period, the total curative effect of TCM symptom scale was higher in 2 weeks than that in 1 week, and the difference was statistically significant (P < 0. 043. 05). Conclusion: Chuanxiong Qingnao granule can significantly reduce the degree of headache attack, reduce the number of headache attacks, improve the symptoms of traditional Chinese medicine, no obvious adverse reactions, good safety, worthy of clinical promotion.
【学位授予单位】：长春中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R277.7

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