清热化湿方治疗2型糖尿病合并高脂血症的临床研究

发布时间：2018-09-19 09:45

【摘要】：目的：探讨中医学对2型糖尿病合并高脂血症的认识,通过临床随机对照实验,观察清热化湿方在治疗2型糖尿病合并高脂血症湿热内蕴证的临床疗效,并为其临床使用提供理论依据。方法：采用1：1平行对照原则分组,选择2型糖尿病合并高脂血症湿热内蕴证的患者60例,分为治疗组、对照组各30例。两组均进行常规降糖、降脂等基础治疗。在此基础上治疗组加用清热化湿方治疗。4周为一个疗程,共3个疗程。3个疗程后分析两组患者症状体征及实验室检查客观指标方面的差异,并评估安全性指标。结果：本临床采用SPSS22.0统计软件进行分析,表明：①两组患者的性别、年龄、病程、中医证候积分以及各项实验室检查指标做治疗前组间均衡性比较,并无显著性差异(P0.05),具有可比性。②两组治疗后均能有效改善患者临床症状(P0.01),治疗组中医证候积分改善优于对照组(P0.01)。中医证候疗效总有效率比较,治疗组明显优于对照组(90%:50%),有统计学差异(P0.01)。③疾病疗效总有效率方面,治疗组优于对照组(86.67%：56.67%),有统计学差异(P0.05)。④血糖、糖化血红蛋白、血脂在治疗后两组均有改善(P0.05),且治疗组效果较对照组为佳(P0.05)。⑤血液流变学方面,两组均能改善血液流变学的部分指标(P0.05),但组间比较无明显统计学差异。⑥两组均未见严重不良反应,肝肾功能检查均在正常范围内。结论：清热化湿方治疗2型糖尿病合并高脂血症湿热内蕴证,能够改善患者临床各项症状,以及实验室指标血糖、血脂、糖化血红蛋白及血流动力学。从初步研究来看,清热化湿方联合西药治疗相对单纯西药治疗效果有明显的优势,且无不良反应,安全有效,值得深入研究及推广。
[Abstract]:Objective: to explore the understanding of type 2 diabetes mellitus with hyperlipidemia in traditional Chinese medicine (TCM), and to observe the clinical effect of clearing heat and removing dampness prescription in treating type 2 diabetes mellitus with hyperlipidemia and hyperlipidemia. And to provide the theoretical basis for its clinical use. Methods: sixty patients with type 2 diabetes mellitus complicated with hyperlipidemia and dampness and heat accumulation were divided into treatment group (n = 30) and control group (n = 30). Both groups were treated with conventional hypoglycemic and lipid-lowering therapy. On this basis, the treatment group was treated with Qingre Huazheng recipe for 4 weeks as a course of treatment for 3 courses. After 3 courses of treatment, the differences of symptoms, signs and objective indexes of laboratory examination between the two groups were analyzed, and the safety indexes were evaluated. Results: the clinical analysis with SPSS22.0 software showed that the sex, age, course of disease, TCM syndromes integral and laboratory examination indexes of the two groups were compared before treatment. There was no significant difference (P0.05). 2 the two groups can effectively improve the clinical symptoms after treatment (P0.01). The improvement of TCM syndromes in the treatment group is better than that in the control group (P0.01). Compared with the total effective rate of TCM syndromes, the treatment group was obviously superior to the control group (90: 50%), and there was statistical difference (P0.01) in the total effective rate of the disease curative effect. The treatment group was superior to the control group (86.67%) (86.67%), there was statistical difference (P0.05) in blood sugar, glycosylated hemoglobin, Blood lipids were improved in both groups after treatment (P0.05), and the effect of the treatment group was better than that of the control group (P0.05). Both groups could improve some indexes of hemorheology (P0.05), but there was no significant difference between the two groups. 6. There was no serious adverse reaction in both groups, and the liver and kidney function were in the normal range. Conclusion: the treatment of type 2 diabetes mellitus with hyperlipidemia and damp-heat accumulation can improve the clinical symptoms, blood sugar, blood lipids, glycosylated hemoglobin and hemodynamics. According to the preliminary study, the combination of clearing heat and removing dampness prescription and western medicine has obvious advantages over that of pure western medicine, and has no adverse reactions, is safe and effective, and is worth further study and popularization.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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