基于关联规则明代治疗头痛方剂用药规律的研究

发布时间：2018-10-05 19:44

【摘要】：目的:运用关联规则对明代治疗头痛方剂进行挖掘分析,总结明代治疗头痛方剂中的主要药物,并分析药物之间的组方配伍规律特点,为现代临床头痛的中医药治疗提供借鉴。方法:以《中医方剂大辞典》中的方剂为数据来源建立相关数据库,并提取其中有关明代治疗头痛的内服方剂作为数据集,选用SPSS Clementine12.0软件对所建数据集中的药物组成进行挖掘,运用Apriori算法建立相关数据挖掘模型,设置最大前项数为5,最小支持度8%,最小置信度70%,并对药物之间的配伍组合以Web节点形式进行图形化展示。结果:获得符合标准的明代治疗头痛的内服方剂共计115首,涉及药物达153种,药物的使用总频次为951次。在所包含的全部药物中,使用超过10次的药物达到32味,其使用频次共计684次,占药物总频次的71.92%。其中在方剂所含药物中,使用频次最高的药类为解表药,共计300次,占各类药物使用总频次的31.55%,其后依次为补虚药、清热药、活血化瘀药、化痰药、理气药、利水渗湿药、祛风湿药、平肝息风药及化湿药等,这些药类的使用频次达816次,共占药物总使用频次的85.80%。通过关联规则分析得到符合条件规则共计336条,其中4味药组合的规则数最多,共产生148条,其次为3味药组合的规则,共获得125条。在所有获得规则中出现频次最多的药物是川芎,其中含川芎的前项规则数为110条,后项规则数为83条,共计193条。在全部符合条件的规则中,拥有较高置信度及支持度的规则有:蔓荆子→川芎、细辛→川芎、白芷→川芎、藁本→川芎、升麻→甘草、藁本+细辛→川芎、蔓荆子+细辛→川芎、荆芥+茶→川芎、荆芥+羌活→白芷、茶+白芷→川芎、防风+细辛→川芎、白芷+细辛→川芎、白芷+甘草→川芎、细辛+甘草→川芎、防风+白芷→川芎、羌活+细辛→川芎、荆芥+白芷→川芎、羌活+细辛+甘草→川芎、羌活+防风+细辛→川芎、羌活+白芷+细辛→川芎、荆芥+羌活+白芷→川芎、白芷+细辛+甘草→川芎、羌活+防风+甘草→川芎等。结论:明代治疗头痛的常用药物为风药,其中川芎是明代治疗头痛的第一要药,且川芎与解表药的配伍组合在明代治疗头痛的方剂中最为常见;补虚药与清热药是明代头痛的常用药类,且与风药之间具有较丰富的配伍;关联规则可用于挖掘古代头痛方剂中药物间的配伍规律研究。
[Abstract]:Objective: to explore and analyze the prescriptions for treating headache in Ming Dynasty by using association rules, summarize the main drugs in the prescriptions of treating headache in Ming Dynasty, and analyze the characteristics of prescription compatibility among them, so as to provide reference for the treatment of headache in modern clinic. Methods: the relevant database was established with the prescriptions in the Big Dictionary of traditional Chinese Medicine as the data source, and the internal prescriptions for treating headache in Ming Dynasty were extracted as data sets. The composition of drugs in the data set was mined by SPSS Clementine12.0 software. The Apriori algorithm is used to set up the data mining model. The maximum number of front terms is 5, the minimum support is 8, and the minimum confidence is 70. The compatibility between drugs is displayed graphically in the form of Web nodes. Results: 115 prescriptions for headache in Ming Dynasty were obtained, 153 kinds of drugs were involved, and the total frequency of drug use was 951 times. Of all the drugs involved, 32 were used more than 10 times, and the total frequency was 684, accounting for 71.92% of the total drug frequency. Among the drugs contained in the prescription, the most frequently used drugs were antitabular drugs (300 times in total), accounting for 31.55 times of the total frequency of use of various kinds of drugs, followed by tonifying drugs, clearing away heat drugs, promoting blood circulation and removing stasis drugs, resolving phlegm drugs, regulating qi drugs, promoting water and infiltrating dampness drugs. The use frequency of these drugs was 816 times, which accounted for 85.80 times of the total use frequency. A total of 336 matching rules were obtained by analyzing association rules, of which the number of four kinds of drugs was the most, and 148 rules were produced, followed by the rules of 3 kinds of drugs, with a total of 125. The most frequent drug in all the rules is Chuanxiong, in which there are 110 rules for the former item and 193 rules for the latter item. Among all the eligible rules, the rules with higher confidence and support are: Ligusticum chinensis, Ligusticum Asarum, Radix angelicae dahurica, Ligusticum ligustii, Radix Glycyrrhiza and Ligustragopsis sinensis, Ligusticum chuanxiong, Chuanxiong, Liangshen, Chuanxiong, Chuanxiong of Radix angelicae dahurica, Ligusticum chuanxiong of Radix Notopterygiae, Ligusticum dahurica, Ligusticum sinensis of Radix angelicae dahurica, Ligusticum chuanxiong of Radix angelicae Sinensis, Rhizoma Notopterygii, Radix angelicae dahuricae Ligusticum, Radix angelicae dahurica Ligusticum Radix angelicae dahurica liquorice Ligusticum, Radix Notopterygii Fangfeng liquorice Ligusticum chuanxiong and so on. Conclusion: the common medicine for treating headache in Ming Dynasty is wind medicine. Chuanxiong is the first important drug in treating headache in Ming Dynasty, and the combination of Ligusticum chuanxiong and antitabular medicine is the most common prescription in the treatment of headache in Ming Dynasty. Tonifying deficiency medicine and heat-clearing medicine are common drugs for headache in Ming Dynasty, and there is a rich compatibility with wind medicine, and association rules can be used to study the compatibility law between drugs in ancient headache prescriptions.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R277.7

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