温中悦肠方配合中药足浴治疗慢性腹泻（虚寒证）临床疗效观察

发布时间：2018-10-09 13:21

【摘要】：研究目的：本研究旨在以慢性腹泻虚寒证患者为研究对象,探讨导师运用中医经验方配合足浴治疗慢性腹泻(虚寒证)的经验及其临床疗效,为进一步开发本病的新型治疗方法提供条件。研究方法：将符合诊断标准的60例慢性腹泻虚寒证患者纳入,随机分为两组,治疗组和对照组各30例。治疗组予以温中悦肠方汤剂,1剂/日,水煎服,早晚分服；配合中药足浴,1次/日。对照组予以蒙脱石散(思密达)口服,3g/次,3次/日。两组均在治疗4周后评价疗效,治疗结束后4周进行随访。研究结果：(1)综合疗效：治疗组30例中,临床有效5例,显效19例,痊愈4例,无效2例,愈显率为76.67%,总有效率为93.33%：对照组30例中,临床有效10例,显效10例,痊愈2例,无效8例,愈显率为40.00%,总有效率为73.33%；治疗组总有效率明显优于对照组(93.33%vs73.33%,P0.05)。(2)临床主要症状：组内比较：两组主要症状治疗后均有改善, (P0.05)：组间比较：治疗后大便泄泻和畏寒肢冷症状改善均比对照组明显(P0.05)。(3)临床次要症状：组内比较：治疗组各次要症状治疗后与治疗前相比均有改善(P0.05)；对照组脘腹痞满、腹胀腹痛症状改善明显(P0.05),而食欲不振、腰膝冷痛症状改善不明显(P0.05)。组间比较：治疗组对于食欲不振、腰膝冷痛症状改善优于对照组(P0.05),两组对于脘腹痞满、腹胀腹痛症状改善相当(P0.05)。(4)安全性评估：两组患者在治疗过程中1均未发生不良反应,治疗前后各安全性检验指标均未发现异常。(5)远期随访：治疗结束后4周内复发率治疗组低于对照组(7.14%vs40.91%,P0.05)。研究结论：温中悦肠方配合中药足浴治疗虚寒型慢性腹泻具有较好疗效,安全性较高,值得临床推广应用。
[Abstract]:Objective: the purpose of this study was to investigate the experience and clinical effect of Chinese medicine experience prescription combined with foot bath in treating chronic diarrhea (deficiency cold syndrome) with chronic diarrhea and cold syndrome. To provide conditions for further development of the new treatment of this disease. Methods: 60 patients with chronic diarrhea and cold syndrome were randomly divided into two groups: treatment group (n = 30) and control group (n = 30). The treatment group was given 1 dose / day of Wenzhong Yueshang decoction, 1 dose of water decoction, divided in the morning and evening, and 1 time / day with traditional Chinese medicine foot bath. In the control group, montmorillonite powder (smecta) was given orally for 3 g / d. Both groups were evaluated after 4 weeks of treatment and followed up 4 weeks after treatment. Results: (1) Comprehensive curative effect: in the treatment group, there were 5 cases of clinical effectiveness, 19 cases of remarkable effect, 4 cases of cure, 2 cases of ineffectiveness, 76.67% of the total effective rate and 93.33% of the total effective rate. In the control group of 30 cases, 10 cases were clinically effective, 10 cases were remarkable effect, 2 cases were cured. The effective rate was 40.00and the total effective rate was 73.33; The total effective rate in the treatment group was significantly better than that in the control group (93.33 vs 73.33 vs P0.05). (2): the main symptoms in the two groups were improved after treatment. (P0.05): the comparison between the two groups: the improvement of stool diarrhea and cold limb symptoms after treatment was better than that of the control group. Significant (P0.05). (3) clinical secondary symptoms: intragroup comparison: treatment group after treatment of secondary symptoms were improved compared with before treatment (P0.05); In the control group, the symptoms of abdominal distension and abdominal pain were improved significantly (P0.05), while the symptoms of anorexia and cold pain of waist and knee were not improved significantly (P0.05). Comparison between groups: the treatment group for loss of appetite, waist and knee cold pain symptoms improved better than the control group (P0.05), the two groups for epigastric fullness, abdominal distension and abdominal pain symptoms improved equivalent (P0.05). (4) safety evaluation: the two groups of patients in the course of treatment 1 did not have adverse reactions, (5) Long-term follow-up: the recurrence rate within 4 weeks after treatment in the treatment group was lower than that in the control group (7.14 vs 40.91). (5) Long-term follow-up: the recurrence rate in the treatment group was lower than that in the control group (7.14 vs 40.91% P 0.05). Conclusion: Wenzhong Yueshang recipe combined with traditional Chinese medicine foot bath has better curative effect and higher safety in treating chronic diarrhea of deficiency cold type, and it is worth popularizing in clinic.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R256.3

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