柴芍承气汤对重症胰腺炎患者胃肠及凝血功能的影响

发布时间：2018-10-10 09:43

【摘要】：目的:观察柴芍承气汤对重症胰腺炎患者胃肠及凝血功能的影响。方法:选择2014年1月——2016年11月90例在该院确诊治疗的重症胰腺炎患者,平均分为两组。对照组采用常规治疗,观察组在此基础上加以柴芍承气汤治疗。观察患者微循环指标(胰腺微血管痉挛、微血管内皮细胞损伤、胰腺微血管通透性、血液流变学)、胃肠功能观察指标(腹痛腹胀持续时间、肠鸣音时间、肛门排气、排便恢复时间),检查细胞因子(血清TNF-α、IL-6、IL-8、GMP-140、TXB2、ET-1、血清NO)水平。结果:观察组胰腺微血管痉挛微血管通透性、微血管内皮细胞损伤及血液流变学的改善例数都明显高于对照组(P0.05)。治疗后两组NO水平显著升高(P0.05),观察组显著大于对照组;ET-1、TXB2、GMP-140水平显著降低;观察组明显低于对照组(P0.05)。两组经治疗后TNF-α、IL-6、IL-8水平明显降低(P0.05),观察组明显低于对照组(P0.05)。观察组腹痛、腹胀持续时间、肠鸣音时间、肛门排气、排便恢复时间明显短于对照组(P0.05)。结论:柴芍承气汤能抑制炎症反应,改善血管通透性、胰腺缺血和微循环,恢复重症胰腺炎患者胃肠运动功能。
[Abstract]:Objective: to observe the effect of Chaishao Chengqi decoction on gastrointestinal and coagulation function in patients with severe pancreatitis. Methods: from January 2014 to November 2016, 90 patients with severe pancreatitis were divided into two groups. The control group was treated with routine therapy, and the observation group was treated with Chaishao Chengqi decoction. The parameters of microcirculation (pancreatic microvasospasm, microvascular endothelial cell injury, pancreatic microvascular permeability, hemorheology), gastrointestinal function (abdominal pain and abdominal distention duration, bowel sound time, anal exhaust) were observed. The levels of cytokines (serum TNF- 伪, IL-6, IL-8, GMP-140 TXB2ET-1, serum NO) were measured. Results: the number of cases of microvascular permeability, injury of microvascular endothelial cells and improvement of hemorheology in the observation group were significantly higher than those in the control group (P0.05). The level of NO in the observation group was significantly higher than that in the control group (P0.05), and the level of GMP-140 in the observation group was significantly lower than that in the control group (P0.05). After treatment, the level of IL-8 of TNF- 伪 was significantly decreased in the two groups (P0.05), and the level of IL-8 in the observation group was significantly lower than that in the control group (P0.05). The duration of abdominal pain, abdominal distention, bowel sounds, anal exhaust and defecation in the observation group were significantly shorter than those in the control group (P0.05). Conclusion: Chaishao-Chengqi decoction can inhibit inflammation, improve vascular permeability, pancreatic ischemia and microcirculation, and restore gastrointestinal motility in patients with severe pancreatitis.
【作者单位】：海南省人民医院重症医学科;
【分类号】：R259

【相似文献】