96例原发性胆汁性肝硬化患者中医证候调查

发布时间：2018-10-11 18:58

【摘要】：目的研究原发性胆汁性肝硬化的临床特征、中医证候分布规律与病机演变规律。方法收集2012年6月至2014年9月在北京地坛医院就诊的96例原发性胆汁性肝硬化患者,调查并记录患者一般情况、主要症状及体征、中医四诊信息,统计不同疾病阶段(慢性肝炎、肝纤维化、肝硬化)症状、证候分布特征。结果 96例患者病位证素以肝、脾、肾为主,部分涉及胆;病性证素有10种,出现频次前5位的依次是气虚(78)、气滞(64)、湿(48)、阴虚(34)、血瘀(33),湿、热表现相对不突出;脏腑失调证素有10种,出现频次前5位的依次是,脾虚(63)、肝郁(57)、肝阴虚(23)、肾阴虚(23)、肾虚(9)、脾阳虚(3)。不同疾病阶段病位证素均以肝、脾为主,后期影响至肾;病性方面,气虚、气滞贯穿全程,阴虚、血瘀渐进加重,湿与热在肝纤维化期最突出;脏腑失调方面,脾虚、肝郁全程较高,肝阴虚、肾阴虚逐渐加重,其中脾虚表现最为突出。结论原发性胆汁性肝硬化患者以气虚、气滞、阴虚、血瘀较为突出,病位以肝、脾、肾为主。
[Abstract]:Objective to study the clinical characteristics, TCM syndromes distribution and pathogenesis of primary biliary cirrhosis. Methods from June 2012 to September 2014, 96 patients with primary biliary cirrhosis were collected from The Temple of Earth Hospital in Beijing. The distribution of symptoms and syndromes in different disease stages (chronic hepatitis, liver fibrosis, liver cirrhosis) was analyzed. Results in 96 patients, liver, spleen and kidney were the main syndromes, some of them were involved in gallbladder, 10 of them were found in the disease syndrome, the first five were qi deficiency (78), qi stagnation (64), dampness (48), yin deficiency (34), blood stasis (33), and the performance of dampness and heat was relatively insignificant. There were 10 kinds of syndromes of viscera disorders, the first five were spleen deficiency (63), liver depression (57), liver yin deficiency (23), kidney deficiency (9), spleen yang deficiency (3). In different disease stages, the main syndromes are liver and spleen, which affect the kidney at the later stage. In the aspect of disease, Qi deficiency, Qi stagnation runs through the whole process, Yin deficiency, blood stasis gradually aggravation, dampness and heat are most prominent in liver fibrosis period; viscera disorder, spleen deficiency, Liver depression is higher in the whole process, liver yin deficiency, kidney yin deficiency gradually aggravation, among which spleen deficiency is the most prominent. Conclusion Qi deficiency, qi stagnation, yin deficiency, blood stasis are more prominent in patients with primary biliary cirrhosis, and liver, spleen and kidney are the main diseases.
【作者单位】：北京中医药大学东直门医院;首都医科大学附属北京地坛医院;首都医科大学研究生部;北京中医药大学研究生部;
【基金】：北京市中医管理局中医药科技项目(JJ2012-15);北京市中医管理局人才培养项目([2011]-146)
【分类号】：R259

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