木香顺气丸对尿毒症前期患者消化功能紊乱的影响及机制研究

发布时间：2018-10-12 17:03

【摘要】：目的观察木香顺气丸对尿毒症前期患者消化功能紊乱的影响并探讨其机制。方法将40例具有消化道症状的尿毒症前期患者随机分为木香顺气组和莫沙必利组,每组20例,另选取20名体检正常人员作为对照组。木香顺气组口服木香顺气丸每次6 g,每天3次,餐后30 min服用。莫沙必利组口服枸橼酸莫沙必利片,每次5 mg,每天3次,餐前30 min服用。疗程为4周。观察患者临床疗效、监测胃电图、血清胃泌素(gastrin,GAS)、胃动素(motilin,MTL)、安全性及复发率。结果木香顺气组总有效率及复发率为90%(18/20)和15%(3/20),莫沙必利组为60%(12/20)和45%(9/20),木香顺气组均优于莫沙必利组(χ~2=4.8,P=0.025;χ~2=4.29,P=0.025)。治疗后,与本组治疗前比较,木香顺气组和莫沙必利组的正常节律百分比升高,胃动过缓率降低,血清GAS及MTL含量升高(P0.05,P0.01);与莫沙必利组比较,木香顺气组胃动过缓率降低明显,血清GAS及MTL含量升高(P0.05,P0.01)。结论木香顺气丸能有效改善尿毒症前期患者消化功能紊乱,其作用机制可能是通过促进患者胃肠动力、调控血清胃肠激素水平,从而改善消化功能。
[Abstract]:Objective to observe the effect of Mu Xiang Shun Qi Pill on digestive dysfunction in patients with uremia and to explore its mechanism. Methods 40 pre-uremic patients with digestive tract symptoms were randomly divided into two groups: Musapride group (n = 20) and Musapride group (n = 20). Muxiang Shunqi group was treated with Muxiang Shunqi pills for 6 g, 3 times a day, 30 min after meal. Mosapride group was treated with mosapride citrate tablets 3 times a day for 5 mg, 30 min before meal. The course of treatment was 4 weeks. Clinical efficacy, electrogastrogram, serum gastrin (gastrin,GAS), motilin (motilin,MTL), safety and recurrence rate were observed. Results the total effective rate and recurrence rate of Musapride group were 90% (18 / 20) and 15% (3 / 20), and those of mosapride group were 60% (12 / 20) and 45% (9 / 20). After treatment, the percentage of normal rhythm increased, the rate of gastric motility was decreased, the contents of GAS and MTL in serum were increased (P0.05, P0.01), and the rate of gastric motility was significantly decreased in Mushan Shunqi group and mosapride group, compared with mosapride group, the percentage of normal rhythm was increased, the rate of gastric motility was decreased, and the contents of serum GAS and MTL were increased (P0.05, P0.01), compared with that of mosapride group. The levels of serum GAS and MTL were increased (P0.05, P0.01). Conclusion Muxiangshunqi pills can effectively improve digestive dysfunction in patients with uremia, and its mechanism may be to improve digestive function by promoting gastrointestinal motility and regulating serum levels of gastrointestinal hormones.
【作者单位】：湖北省武汉市中心医院胃肠外科;湖北省武汉市中心医院肾内科;
【分类号】：R277.5

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