丹红注射液对高血压肾损害患者肾功能影响的系统评价
发布时间：2018-10-15 11:25
【摘要】：目的探讨丹红注射液治疗对高血压肾损害患者肾功能的影响。方法检索并筛选丹红注射液治疗高血压肾损害的随机对照研究,检索范围包括中国知网系列数据库(CNKI)、万方数据库、中国生物医学文献数据库(CBM)、The Cochrane Library、Pub Med。中文检索词为丹红、丹红注射液、高血压合并肾损害、高血压性肾损害、高血压肾病,英文检索词为Danhong、hypertension、hypertensive、renal。检索截至2016年12月31日公开发表的已有文献,采用Cochrane系统评价手册偏倚风险评估工具评估纳入研究的偏倚风险,采用Rev Man 5.2软件对选取的随机对照研究资料进行Meta分析。结果纳入9项合格临床试验文献,共计951例患者,其中5项试验研究样本量50例;临床试验仅提及随机分组但均未说明具体随机分配方法,均未采用盲法观察,纳入研究方法学偏倚风险较高。临床疗效分析结果显示,丹红注射液治疗可降低高血压肾损害患者尿微量白蛋白[均数差(MD)=-11.12mg/L,95%CI为(-13.53~-8.72)mg/L]、尿β2微球蛋白[MD=-0.12 mg/L,95%CI为(-0.15~-0.08)mg/L]、血肌酐[MD=-40.26μmol/L,95%CI为(-57.90~-22.61)μmol/L]、血尿素氮[MD=-1.54 mmol/L,95%CI为(-2.76~-0.31)mmol/L],提高内生肌酐清除率[MD=26.26 m L/min,95%CI为(14.91~37.62)m L/min],与对照组比较差异有统计学意义(P均0.05)。文献发表偏倚的倒漏斗图不对称,提示存在一定的发表偏倚风险。结论丹红注射液可减少高血压肾损害患者尿蛋白的排泄,改善肾功能,具有较好的临床疗效;但小样本、异质性和高偏倚风险研究可能影响结果的可靠性。
[Abstract]:Objective to investigate the effect of Danhong injection on renal function in hypertensive patients with renal damage. Methods A randomized controlled study was conducted to search and screen Danhong injection for the treatment of hypertensive renal damage. The search scope included (CNKI), Wanfang database and (CBM), The Cochrane Library,Pub Med. database of Chinese biomedical literature. Chinese key words are Danhong, Danhong injection, hypertension with renal damage, hypertensive nephropathy, English key words are Danhong,hypertension,hypertensive,renal. To search the literature published as of December 31, 2016, the bias risk was evaluated by the Cochrane system Evaluation Manual, and the selected randomized controlled study data was analyzed by Meta using Rev Man 5.2 software. Results A total of 951 patients were included in 9 qualified clinical trials, of which 50 were studied in 5 trials. The clinical trials only mentioned random grouping but did not describe the specific randomized distribution method, and none of them were observed by blind method. The risk of methodological bias is higher. The results of clinical efficacy analysis showed that 涓圭孩娉ㄥ皠娑叉不鐤楀彲闄嶄綆楂樿鍘嬭偩鎹熷鎮ｈ，
本文编号：2272398
[Abstract]:Objective to investigate the effect of Danhong injection on renal function in hypertensive patients with renal damage. Methods A randomized controlled study was conducted to search and screen Danhong injection for the treatment of hypertensive renal damage. The search scope included (CNKI), Wanfang database and (CBM), The Cochrane Library,Pub Med. database of Chinese biomedical literature. Chinese key words are Danhong, Danhong injection, hypertension with renal damage, hypertensive nephropathy, English key words are Danhong,hypertension,hypertensive,renal. To search the literature published as of December 31, 2016, the bias risk was evaluated by the Cochrane system Evaluation Manual, and the selected randomized controlled study data was analyzed by Meta using Rev Man 5.2 software. Results A total of 951 patients were included in 9 qualified clinical trials, of which 50 were studied in 5 trials. The clinical trials only mentioned random grouping but did not describe the specific randomized distribution method, and none of them were observed by blind method. The risk of methodological bias is higher. The results of clinical efficacy analysis showed that 涓圭孩娉ㄥ皠娑叉不鐤楀彲闄嶄綆楂樿鍘嬭偩鎹熷鎮ｈ，
本文编号：2272398
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