补肾祛湿法治疗复发性生殖器疱疹对血清Th17细胞和IL-17表达水平的影响
发布时间：2018-10-15 14:18
【摘要】：目的观察补肾祛湿中药治疗复发性生殖器疱疹(RGH)的临床疗效,探讨Th17细胞、白细胞介素(IL)-17在RGH发病中的作用。方法将60例RGH患者用随机数字表法分为补肾祛湿组及阿昔洛韦组各30例,另选择健康对照者30例(健康对照组),补肾祛湿组给予补肾祛湿中药汤剂(补肾祛湿中药复方组成:盐牛膝10 g,黄柏15 g,黄芪30 g,当归20 g,苍术20 g,土茯苓20 g,板蓝根30 g,大青叶10 g,马齿苋30 g,柴胡6 g,粉葛30g,蜂房10 g,甘草6 g),阿昔洛韦组给予阿昔洛韦口服,疗程均为6个月;用流式细胞仪检测RGH患者及健康对照组外周血中Th17细胞的比例,ELISA法检测外周血血清IL-17水平。结果治疗后补肾祛湿组临床症状评分显著低于阿昔洛韦组,差异有统计学意义(P0.05);补肾祛湿组愈显率高于阿昔洛韦组,差异有统计学意义(P0.05);两组RGH患者治疗前外周血中Th17细胞比例及IL-17水平均明显高于健康对照组,差异有统计学意义(P0.05);两组RGH患者经治疗后Th17细胞比例及IL-17水平均下降,补肾祛湿组下降程度显著大于阿昔洛韦组,差异有统计学意义(P0.05)。结论补肾祛湿法治疗RGH可显著改善患者临床症状和体征,提高临床疗效,降低血清Th17细胞比例及IL-17水平。Th17细胞及IL-17可能参与了RGH的发病过程。
[Abstract]:Objective to observe the clinical effect of tonifying the kidney and removing dampness in the treatment of recurrent genital herpes (RGH), and to explore the role of Th17 cells and interleukin (IL) 17 in the pathogenesis of RGH. Methods 60 patients with RGH were randomly divided into two groups: the group of tonifying kidney and dispelling dampness and the group of acyclovir (n = 30). Another 30 healthy controls (healthy control group) were selected. The group of tonifying kidney and dispelling dampness was given traditional Chinese medicine decoction of tonifying kidney and removing dampness. Radix Isatidis 30 g, Isatidis root 10 g, Portulaca oleracea 30 g, Bupleurum 6 g, Pueraria lobata 30 g, honeycomb 10 g, Glycyrrhiza 6 g), acyclovir orally. Flow cytometry was used to detect the proportion of Th17 cells in peripheral blood of patients with RGH and healthy controls, and ELISA method was used to detect the level of IL-17 in peripheral blood. Results after treatment, the clinical symptom score of tonifying kidney and removing dampness group was significantly lower than that of acyclovir group, the difference was statistically significant (P0.05), and the effective rate of healing in tonifying kidney dispelling dampness group was higher than that in acyclovir group. The proportion of Th17 cells and IL-17 level in peripheral blood of RGH patients before treatment were significantly higher than those in healthy control group (P0.05). The proportion of Th17 cells and IL-17 level in RGH patients of two groups decreased after treatment. The decreasing degree of tonifying kidney and removing dampness group was significantly higher than that of acyclovir group, the difference was statistically significant (P0.05). Conclusion the method of tonifying the kidney and removing dampness can significantly improve the clinical symptoms and signs, increase the clinical efficacy, decrease the proportion of serum Th17 cells and the level of IL-17. Th17 cells and IL-17 may be involved in the pathogenesis of RGH.
【作者单位】： 广州医科大学附属第三医院皮肤科;广州中医药大学第一附属医院检验科;广州中医药大学第一附属医院皮肤科;广州中医药大学第三附属医院皮肤科;
【基金】：广东省中医药局建设中医药强省科研课题(编号:20141083)
【分类号】：R275.9
[Abstract]:Objective to observe the clinical effect of tonifying the kidney and removing dampness in the treatment of recurrent genital herpes (RGH), and to explore the role of Th17 cells and interleukin (IL) 17 in the pathogenesis of RGH. Methods 60 patients with RGH were randomly divided into two groups: the group of tonifying kidney and dispelling dampness and the group of acyclovir (n = 30). Another 30 healthy controls (healthy control group) were selected. The group of tonifying kidney and dispelling dampness was given traditional Chinese medicine decoction of tonifying kidney and removing dampness. Radix Isatidis 30 g, Isatidis root 10 g, Portulaca oleracea 30 g, Bupleurum 6 g, Pueraria lobata 30 g, honeycomb 10 g, Glycyrrhiza 6 g), acyclovir orally. Flow cytometry was used to detect the proportion of Th17 cells in peripheral blood of patients with RGH and healthy controls, and ELISA method was used to detect the level of IL-17 in peripheral blood. Results after treatment, the clinical symptom score of tonifying kidney and removing dampness group was significantly lower than that of acyclovir group, the difference was statistically significant (P0.05), and the effective rate of healing in tonifying kidney dispelling dampness group was higher than that in acyclovir group. The proportion of Th17 cells and IL-17 level in peripheral blood of RGH patients before treatment were significantly higher than those in healthy control group (P0.05). The proportion of Th17 cells and IL-17 level in RGH patients of two groups decreased after treatment. The decreasing degree of tonifying kidney and removing dampness group was significantly higher than that of acyclovir group, the difference was statistically significant (P0.05). Conclusion the method of tonifying the kidney and removing dampness can significantly improve the clinical symptoms and signs, increase the clinical efficacy, decrease the proportion of serum Th17 cells and the level of IL-17. Th17 cells and IL-17 may be involved in the pathogenesis of RGH.
【作者单位】： 广州医科大学附属第三医院皮肤科;广州中医药大学第一附属医院检验科;广州中医药大学第一附属医院皮肤科;广州中医药大学第三附属医院皮肤科;
【基金】：广东省中医药局建设中医药强省科研课题(编号:20141083)
【分类号】：R275.9
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