参麦四逆汤联用贝那普利和螺内酯对慢性心力衰竭患者LVEF及生存结局的影响

发布时间：2018-10-16 12:23

【摘要】：目的:观察参麦四逆汤对慢性心力衰竭患者左室射血分数(left ventricular ejection fraction,LVEF)及生存结局的影响。方法:将符合准入条件的慢性心力衰竭80例门诊患者编号,放置到随机数字生成器Random Maker系统随机抽取治疗组50例,对照组30例。两组原基础疾病的治疗方案不改变,对照组用贝那普利和螺内酯治疗,治疗组在对照组治疗的基础上应用参麦四逆汤治疗。1年后观察两组患者的LVEF、年均住院次数、1年内的生存结局(存活数量和死亡数量)。结果:治疗组与对照组比较,在提高LVEF、降低年均住院次数、改善生存结局方面优于对照组(P0.05)。不良反应心律失常发生率治疗组低于对照组(P0.05),其余各项不良反应均无明显差异(P0.05)。结论:参麦四逆汤在改善慢性心力衰竭患者心功能同时,降低了年均住院次数,同时改善了生存结局(降低死亡率),降低心律失常发生率。
[Abstract]:Aim: to observe the effect of Shenmai Sini decoction on left ventricular ejection fraction (left ventricular ejection fraction,LVEF) and survival outcome in patients with chronic heart failure. Methods: 80 outpatients with chronic heart failure who met the admission criteria were assigned to random sampling treatment group (50 cases) and control group (30 cases) by random number generator (Random Maker) system. There was no change in the treatment of the primary diseases in the two groups, while the control group was treated with benazepril and spironolactone. The treatment group was treated with Shenmai Sini decoction on the basis of the control group. One year later, the average number of LVEF, hospitalizations and the survival outcome (number of survival and death) of the two groups were observed. Results: compared with the control group, the treatment group was superior to the control group in increasing the average number of hospitalization and improving the survival outcome of LVEF, (P0.05). The incidence of arrhythmia in the treatment group was lower than that in the control group (P0.05), but there was no significant difference in other adverse reactions (P0.05). Conclusion: Shenmai Sini decoction can improve the heart function of patients with chronic heart failure, reduce the annual hospitalization times, improve the survival outcome (reduce mortality) and reduce the incidence of arrhythmia.
【作者单位】：深圳市大鹏新区南澳人民医院;
【基金】：深圳市科技研发基金项目(编号:JCYJ20150401104212099)
【分类号】：R541.6

【相似文献】