柴胡疏肝散加减治疗肝郁气滞型经前期综合征的临床观察

发布时间：2018-10-22 20:41

【摘要】：目的:本研究主要观察了柴胡疏肝散加减治疗肝郁气滞型经前期综合征的临床疗效,并对此法进行疗效评估。为本法在临床上应用及推广提供依据。研究方法:本研究纳入了 64例肝郁气滞型经前综合征的患者,随机分为治疗组与对照组,每组32例。治疗组口服柴胡疏肝散的方法进行治疗,对照组口服盐酸氟西汀片。共治疗3个月经周期。观察两组患者治疗后各症状积分及相关疗效指标的改善情况。结果:1.临床疗效分析:治疗组总好转率为80%,对照组总好转率为74.2%,两组相比P0.05,无显著性差异,说明柴胡疏肝散和盐酸氟西汀片均可以改善PMS的症状。2.中医证候分析:两组患者中医证候疗效的比较,治疗组总有效率为90%,对照组总有效率为67.7%,P0.05,有显著性差异,说明在改善中医证候方面,柴胡疏肝散优于盐酸氟西汀片。3.内分泌孕酮(P)分析:治疗后两组的孕酮比较(P0.05),差异无统计学意义。两组治疗前后孕酮比较(P0.05),无显著性差异,说明两组治疗方法对患者的孕酮水平几乎没有影响。4.远期疗效分析:两组患者在治疗结束后3个月进行疗效评估,其中治疗组总有效率为76.7%,对照组总有效率为45.2%,P0.05,有显著性差异,说明在治疗肝郁气滞型经前期综合征的远期疗效上柴胡疏肝散明显优于盐酸氟西汀片。结论:1.柴胡疏肝散加减能够有效的改善肝郁气滞型经前期综合征的症状,其总好转率为80%。2.柴胡疏肝散加减对改善肝郁气滞型经前期综合征的中医证候良好的成效,其总有效率为90%,优于盐酸氟西汀片。3.柴胡疏肝散加减不仅能有效改善肝郁气滞型经前期综合征的各症状体征,而且其远期疗效明显的优于西药。在用药期间,柴胡疏肝散未出现明显的副作用,可以作为治疗经前期综合征的一种安全有效方法,值得在临床实践及科学研究上推广应用。
[Abstract]:Objective: to observe the clinical effect of Chaihu Shugan Powder in treating premenstrual syndrome of stagnation of liver qi. To provide the basis for the clinical application and popularization of this method. Methods: 64 patients with premenstrual syndrome of stagnation of liver-qi were randomly divided into treatment group and control group with 32 cases in each group. The treatment group was treated with Chaihu Shugan Powder and the control group with fluoxetine hydrochloride tablets. A total of 3 menstrual cycles were treated. To observe the improvement of symptom score and related curative effect index after treatment in the two groups. The result is 1: 1. Clinical efficacy analysis: the total improvement rate of treatment group was 80 and that of control group was 74.2. There was no significant difference between the two groups compared with P0.05, indicating that both Chaihu Shugan San and fluoxetine hydrochloride tablets could improve the symptoms of PMS. 2. Analysis of TCM syndromes: the total effective rate of treatment group was 90, the total effective rate of control group was 67.7% (P0.05), which indicated that Chaihu Shugan Powder was superior to fluoxetine Hydrochloride tablet in improving TCM syndromes. Endocrine progesterone (P) analysis: after the treatment of progesterone comparison between the two groups (P0.05), the difference was not statistically significant. There was no significant difference in progesterone levels between the two groups before and after treatment (P0.05), indicating that there was almost no effect on progesterone level in the two groups. Long-term curative effect analysis: the two groups were evaluated at 3 months after the end of treatment. The total effective rate of the treatment group was 76.7, the total effective rate of the control group was 45.2% (P 0.05), there was significant difference between the two groups. It indicated that the long-term curative effect of chaihu Shugan San was better than fluoxetine hydrochloride tablet in the treatment of premenstrual syndrome with stagnation of liver and qi. Conclusion: 1. The addition and subtraction of Chaihu Shugan San can effectively improve the symptoms of premenstrual syndrome of liver depression and qi stagnation type, and its total improvement rate is 80.2. The addition and subtraction of Chaihu Shugan San has good effect on improving the syndrome of premenstrual syndrome of liver depression and qi stagnation type. Its total effective rate is 90, which is better than fluoxetine hydrochloride tablet. The addition and subtraction of Chaihu Shugan San can not only effectively improve the symptoms and signs of premenstrual syndrome of liver depression and qi stagnation, but also have a better long-term effect than western medicine. During the period of medication, Chaihu Shugan Powder has no obvious side effects, which can be regarded as a safe and effective method for the treatment of premenstrual syndrome. It is worth popularizing and applying in clinical practice and scientific research.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R271.115

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