丹蒌片治疗老年慢性稳定型心绞痛（痰瘀互结型）的临床观察

发布时间：2018-10-23 20:40

【摘要】：目的:用丹萎片和阳性药物利脑心胶囊做对比,治疗老年慢性稳定型劳累性心绞痛痰瘀互阻型的患者,评价丹蒌片治疗老年慢性稳定型劳累性心绞痛痰瘀互阻型的临床效果及用药安全性。材料与方法:将2014年12月至2015年12月我院收治的46例老年慢性稳定型劳累性心绞痛患者用随机数表的方法随机分为丹蒌片治疗组(23例)和阳性药物对照组(23例)。阳性对照组患者在常规西药治疗基础上加利脑心胶囊,丹蒌片治疗组患者在使用西药治疗的基础上加用丹萎片进行治疗,疗程为2个月。分别于治疗前后检测肝功能、肾功能、凝血五项、血常规、尿常规、便常规、心电图。对比分析两组患者在改善心绞痛症状方面的临床疗效。试验期间观察的指标包括,治疗前后心绞痛症状评分(疼痛程度、发作次数、持续时间、硝酸甘油用量)、中医症候评分(包括胸闷、胸痛、心悸、气短、唇色紫暗、神疲乏力、体胖、多痰、身体困重)、平板运动试验的Duke评分及西雅图量心绞痛量表积分。用统计学方法统计处理各观察指标的统计学意义。结果:在缓解心绞痛症状方面,治疗组患者治疗的总有效率为82.6%,对照组患者治疗的总有效率为56.5%,二者相比差异显著((p=0.004,p0.05),有统计学意义;在中医症候评分比较方面,治疗组患者治疗的总有效率为91.3%,对照组患者治疗的总有效率为21%,二者相比差异显著((p=0.000,p0.05),有统计学意义;比较两组治疗前后平板运动的Duke评分,治疗组治疗前后p=0.025,对照组治疗前后p=0.397,治疗组优于对照组;两组治疗后西雅图心绞痛量表积分比较,p=0.00,p0.05,有统计学意义,治疗组优于对照组。两组患者治疗均未出现某项安全指标的异常。结论:丹萎片治疗老年痰瘀互阻型性慢性稳定性心绞痛可取得显著的临床疗效,有效缓解心绞痛症状,改善中医临床症候,运动耐量情况及西雅图心绞痛积分情况。而且具有较高的用药安全性,能有效的改善患者的生活质量。
[Abstract]:Objective: to treat elderly patients with chronic stable angina pectoris with phlegm and blood stasis obstruction by using Danwei tablet and positive drug Liniaoxin capsule. To evaluate the efficacy and safety of Danlou tablet in treating senile chronic stable angina pectoris with phlegm and blood stasis obstruction. Materials and methods: from December 2014 to December 2015, 46 elderly patients with chronic stable angina pectoris were randomly divided into two groups: treatment group (n = 23) and control group (n = 23). The patients in the positive control group were treated with Linaoxin capsule on the basis of routine western medicine, and the patients in the treatment group were treated with Danwei tablet on the basis of western medicine. The course of treatment was 2 months. Liver function, kidney function, coagulation, blood routine, urine routine, stool routine and electrocardiogram were detected before and after treatment. Comparative analysis of the two groups of patients in improving the symptoms of angina pectoris clinical efficacy. The indexes observed during the trial included scores of angina pectoris symptoms before and after treatment (degree of pain, number of episodes, duration, dosage of nitroglycerin), scores of TCM symptoms (including chest tightness, chest pain, palpitations, shortness of breath, dark purple lips, fatigue and fatigue). Body fat, phlegm, body weight), the Duke score of treadmill exercise test and the score of Seattle angina pectoris scale. Statistical method was used to deal with the statistical significance of each observation index. Results: the total effective rate was 82.6 in the treatment group and 56.5 in the control group. The difference between the two groups was significant (p0.004 / p0.05). The total effective rate of the treatment group was 91.3 and that of the control group was 21. The difference between the two groups was significant (P < 0.05). The Duke scores of treadmill exercise before and after treatment were compared between the two groups. Before and after treatment, the treatment group was better than the control group in p0. 025, the control group was better than the control group before and after treatment, and the score of Seattle angina pectoris scale was significantly higher in the two groups after treatment than that in the control group. There was no abnormal safety index in both groups. Conclusion: Danwei tablet can obtain remarkable clinical curative effect in treating senile chronic stable angina pectoris of phlegm and blood stasis mutual obstruction. It can effectively relieve the symptoms of angina pectoris improve the clinical symptoms exercise tolerance and the score of Seattle angina pectoris. Moreover, it has higher drug safety and can effectively improve the quality of life of patients.
【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259
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本文编号：2290404