复元活血汤治疗气滞血瘀型椎动脉型颈椎病的临床研究

发布时间：2018-10-24 18:05

【摘要】：目的:观察复元活血汤治疗气滞血瘀型椎动脉型颈椎病的临床疗效,并探讨其作用机理,为临床治疗本病提供新的思路。方法:按入院先后顺序将2014年10月至2016年3月于青州市人民医院入院的患者采用随机数字表法随机分为治疗组50例和对照组48例。治疗组使用复元活血汤,对照组使用颈复康颗粒,30天为一疗程。对病人进行用药前后的量表评定及椎动脉血流速度检测,两组进行对比。结果:治疗一个疗程后,治疗组总有效率96%优于对照组总有效率88%。治疗后两组颈椎功能障碍指数较治疗前均明显降低,P0.001,且治疗组(3.32±2.66)较对照组(4.74±3.48)降低明显,P=0.024;治疗后两组视觉模拟评分较治疗前均明显减小,P0.001,而治疗组视觉模拟评分(1.94±1.30)较对照组(2.54±1.15)减小更为明显,P=0.016;治疗后两组椎动脉血流速度(双侧收缩期血流速度、舒张末期血流速度)较治疗前均明显增快,P0.001,治疗后治疗组左椎动脉收缩期血流速度(43.30±9.58)、舒张末期血流速度(25.30±4.78),右椎动脉收缩期血流速度(41.80±9.40)、舒张末期血流速度(24.82±5.86)分别较对照组左椎动脉收缩期血流速度(38.56±6.23);舒张末期血流速度(22.52±6.28);右椎动脉收缩期血流速度(37.66±9.92);舒张末期血流速度(22.28±6.56)改善明显(P=0.004;0.014;0.035;0.033)。结论:复元活血汤用于治疗气滞血瘀型椎动脉型颈椎病疗效优于颈复康颗粒。其作用机制可能与以下因素有关:增快椎动脉血流速度,改善椎动脉血流状态,促进受损神经组织的恢复。
[Abstract]:Objective: to observe the clinical effect of Fuyuan Huoxue decoction in treating cervical spondylosis of vertebral artery type of Qi stagnation and blood stasis type, and to explore its mechanism, and to provide a new idea for clinical treatment of this disease. Methods: patients admitted to Qingzhou people's Hospital from October 2014 to March 2016 were randomly divided into treatment group (n = 50) and control group (n = 48). The treatment group was treated with Fuyuan Huoxue decoction and the control group with Jingfukang granule for 30 days. The patients were assessed with the scale before and after treatment and the blood flow velocity of vertebral artery was measured, and the two groups were compared. Results: after a course of treatment, the total effective rate of the treatment group was 96% better than that of the control group. After treatment, the cervical spine dysfunction index in both groups was significantly lower than that before treatment (P 0.001), and in the treatment group (3.32 卤2.66) was significantly lower than that in the control group (4.74 卤3.48), the visual analogue score in the two groups was significantly lower than that before treatment (P 0.001), and the visual analogue score in the treatment group (1.94 卤1.30) was significantly lower than that in the control group (4.74 卤3.48). Compared with the control group (2.54 卤1.15), the blood flow velocity of vertebral artery decreased significantly (P < 0.016). After treatment, left vertebral artery systolic velocity (43.30 卤9.58), end-diastolic blood flow velocity (25.30 卤4.78), right vertebral artery systolic flow velocity (41.80 卤9.40) and end-diastolic blood flow velocity (24.82 卤5.86) were significantly faster than those before treatment. In the control group, left vertebral artery systolic velocity (38.56 卤6.23), end-diastolic flow velocity (22.52 卤6.28), right vertebral artery systolic velocity (37.66 卤9.92) and end-diastolic flow velocity (22.28 卤6.56) were significantly improved (P < 0.004). Conclusion: Fuyuan Huoxue decoction is superior to Zhifukang granule in treating cervical spondylosis of vertebral artery type of Qi stagnation and blood stasis. The mechanism may be related to the following factors: increasing the blood flow velocity of the vertebral artery, improving the blood flow status of the vertebral artery, and promoting the recovery of injured nerve tissue.
【学位授予单位】：青岛大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R274.9
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本文编号：2292142