清化承气汤治疗AECOPD（痰热腑实证）的临床研究

发布时间：2018-10-25 15:35

【摘要】：目的:基于清化承气汤对慢性阻塞性肺疾病急性加重期(AECOPD)痰热腑实证的临床研究,客观评价清化承气汤治疗AECOPD痰热腑实证的有效性和安全性,为肺肠同治法治疗AECOPD提供相应的临床数据。方法:将符合纳入标准的60例AECOPD痰热腑实证的患者随机分为治疗组和对照组各30例,两组均采用符合西医诊疗规范的治疗方案,治疗组在此基础上加用清化承气汤,临床观察9天,以SPSS21为统计软件,通过对比两组患者治疗前后的相关体征及症状评分等数据来评价两组的疗效。结果:入组病例以65-75岁的男性居多。经治疗,两组体征和症状评分都得到了明显的改善,治疗组总有效率达93.3%,对照组总有效率达86.7%,两组间在咳嗽、咳痰、呼吸困难、腹胀、便秘等主要症状,听诊Up音、肺功能(FEV_1/FVC,FEV_1%)、有效率、有效所需天数等方面存在统计学差异。结论:对于AECOPD痰热腑实证的治疗,加用清化承气汤以泻热通腑的治疗组疗效优于单纯西医治疗组,对咳嗽、咳痰、呼吸困难等肺系症状,腹胀、便秘等腑气不通症状有更为明显的改善作用,进而提高AECOPD痰热腑实证患者的生命质量,说明以肺与大肠相表里理论为指导的肺肠同治法可以应用于AECOPD痰热腑实证,具有临床意义和社会效益,值得进一步深入研究。
[Abstract]:Objective: to evaluate the efficacy and safety of Qinghua Chengqi decoction in treating (AECOPD) phlegm-heat syndrome in acute exacerbation of chronic obstructive pulmonary disease (COPD). To provide the corresponding clinical data for the treatment of AECOPD. Methods: sixty patients with AECOPD phlegm and heat were randomly divided into treatment group (n = 30) and control group (n = 30). The treatment group were treated with Qinghua Chengqi decoction. After 9 days of clinical observation, SPSS21 was used as statistical software to evaluate the efficacy of the two groups by comparing the data of signs and symptom scores before and after treatment. Results: male patients aged 65-75 years were the majority of the patients. After treatment, the physical signs and symptom scores of the two groups were obviously improved. The total effective rate of the treatment group was 93.3 and the total effective rate of the control group was 86.7. The main symptoms of the two groups were cough, expectoration, dyspnea, abdominal distension, constipation, and so on. Auscultation Up sounds. There were significant differences in lung function (FEV_1/FVC,FEV_1%), effective rate and effective days. Conclusion: for the treatment of AECOPD syndrome of phlegm and heat, the treatment group with Qinghua Chengqi decoction for purging heat and clearing the Fu is better than the western medicine group in the treatment of cough, expectoration, dyspnea and other pulmonary system symptoms, abdominal distension, and so on. Constipation and other symptoms can improve the quality of life of patients with phlegm and heat in AECOPD. It shows that the method of lung and intestine syndromes therapy can be applied to the diagnosis of phlegm and heat in AECOPD, which is guided by the theory of lung and large intestine. It has clinical significance and social benefit, and is worthy of further study.
【学位授予单位】：西南医科大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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