苓泽合剂治疗湿热瘀阻型急性痛风性关节炎临床观察

发布时间：2018-10-26 12:59

【摘要】：目的:基于络病理论组方苓泽合剂,观察其治疗湿热瘀阻型急性痛风性关节炎临床疗效。材料与方法:选取急性痛风性关节炎(湿热瘀阻证)患者共114例,按照随机分组原则分为苓泽合剂组(治疗组)57例和痛风定胶囊组(对照组)57例,疗程为7天,每周观察记录病情1次,随访28天后,比较两组治疗前后的中医证候积分、疼痛评分、实验室指标、临床疗效及安全情况,进行观察并分析总结。结果:1.中医临床疗效治疗组总有效率为92.85%,对照组总有效率为82.14%。治疗组与对照组比较有统计学意义(P0.01)。2.治疗组与对照组中医证候积分、疼痛评分治疗前组间比较无统计学意义(P0.05);组内治疗前、后评分比较均有统计学意义(P0.01);治疗后组间比较有统计学意义(P0.01)。3.治疗组与对照组血沉、C反应蛋白、血尿酸治疗前组间比较无统计学意义(P0.05);血沉、C反应蛋白、血尿酸组内治疗前、后评分比较均有统计学意义(P0.01);血沉、C反应蛋白治疗后组间比较有统计学意义(P0.01),血尿酸治疗后组间比较没有统计学意义(P0.05)。4.治疗组与对照组治疗后患者对止痛疗效判定比较差异有统计学意义(P0.01)。5.治疗组与对照组谷丙转氨酶、谷草转氨酶、尿素氮、肌酐、甘油三酯、总胆固醇治疗前组间比较无统计学意义(P0.05);组内治疗前、后评分比较均无统计学意义(P0.05);治疗后组间比较无统计学意义(P0.05)。结论:1.苓泽合剂治疗急性痛风性关节炎(湿热瘀阻型)有确切疗效。2.苓泽合剂中医症候积分缓解程度优于痛风定胶囊。3.苓泽合剂缓解疼痛效果优于痛风定胶囊。4.苓泽合剂降低血沉、C反应蛋白效果优于痛风定胶囊。5.苓泽合剂可降低血尿酸,与痛风定胶囊无差异。6.短期应用苓泽合剂治疗痛风性关节炎对肝、肾功能无损害。
[Abstract]:Objective: to observe the clinical effect of Lingze mixture in treating acute gouty arthritis of damp-heat stasis type based on collateral disease theory. Materials and methods: 114 patients with acute gouty arthritis (damp-heat stasis syndrome) were randomly divided into Lingze mixture group (treatment group) (57 cases) and gout ding capsule group (control group) 57 cases, the course of treatment was 7 days. The patients were observed and recorded once a week and followed up for 28 days. The scores of TCM syndromes, pain scores, laboratory indexes, clinical efficacy and safety were compared before and after treatment. The result is 1: 1. The total effective rate was 92.85 in the treatment group and 82.14 in the control group. Compared with the control group, the treatment group had statistical significance (P0.01). The scores of TCM syndromes and pain scores in the treatment group and the control group were not statistically significant (P0.05); the scores before and after treatment in the treatment group were statistically significant (P0.01). After treatment, there was significant difference between the two groups (P0.01). There was no significant difference in erythrocyte sedimentation rate, C-reactive protein and hematuria before treatment between the treatment group and the control group (P0.05), but the scores of ESR, C-reactive protein and hematuria acid group were statistically significant before and after treatment (P0.01). The erythrocyte sedimentation rate (ESR), C-reactive protein (C-reactive protein) after treatment was statistically significant (P0.01), but there was no statistical significance after hematuric acid treatment (P0.05). There was significant difference between the treatment group and the control group in the evaluation of analgesic effect (P0.01). There was no significant difference between treatment group and control group before treatment with alanine aminotransferase, urea nitrogen, creatinine, triglyceride and total cholesterol (P0.05). The scores before and after treatment were not statistically significant (P0.05); after treatment there was no statistical significance (P0.05). Conclusion: 1. Lingze mixture has definite curative effect on acute gouty arthritis (damp-heat stasis type). 2. Lingze mixture is better than Tongfengding capsule. 3. Lingze mixture is better than Tongfengding capsule in relieving pain. 4. Lingze mixture reduced erythrocyte sedimentation rate, C reactive protein effect was better than Tongfengding capsule. 5. Lingze mixture can reduce blood uric acid, and Tongfengding capsule no difference. 6. The short-term application of Lingze mixture in treating gouty arthritis has no damage to liver and kidney function.
【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259

【参考文献】