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止带方加味治疗湿热下注型细菌性阴道病的临床观察

发布时间:2018-10-30 09:30
【摘要】:目的:本研究采用止带方加味治疗湿热下注型细菌性阴道病(bacterial vaginosis,BV),通过观察治疗后临床症状及阴道分泌物实验室指标变化,从而评价止带方加味治疗湿热下注型细菌性阴道病的临床疗效。方法:将临床诊断为湿热下注型BV的66例患者,随机分为治疗组及对照组各33例。在研究过程中对照组有1例患者因未按时口服药物而脱落。治疗组予以口服止带方加味及甲硝唑片,对照组予以口服甲硝唑片。治疗1周,停药1周后复查患者阴道分泌物,重新评估患者中医症状及妇科检查局部体征,痊愈及显效者随访2个月经周期。结果:1.两组综合疗效比较,治疗组痊愈率高于对照组,差异有统计学意义(P0.05),两组总疗效相比差异无统计学意义(P0.05)。2.治疗组可明显改善患者中医症状,与治疗前比较差异有统计学意义(P0.05),与对照组相比优于对照组,差异有统计学意义(P0.05)。3.治疗组可明显改善患者阴道分泌物"清洁度"、"线索细胞"、"胺味试验"、"PH值",与治疗前比较差异有统计学意义(P0.05)。治疗组在改善阴道分泌物"清洁度"方面优于对照组,差异有统计学意义(P0.05)。两组在改善其他三项方面比较差异无统计学意义(P0.05)。4.治疗组可明显改善患者妇科检查局部体征,与治疗前比较差异有统计学意义(P0.05),与对照组比较差异无统计学意义(P0.05)。5.在随访过程中发现,治疗组在恢复阴道乳酸杆菌及降低复发率方面优于对照组,差异有统计学意义(P0.05)。6.治疗组治疗前后安全性指标均正常,无明显不良反应出现。结论:1.止带方加味联合甲硝唑片可改善患者临床症状体征,改善患者阴道分泌物实验室检查各项指标。2.止带方加味联合甲硝唑片,在改善患者中医症候、改善阴道分泌物清洁度、恢复阴道乳酸杆菌及降低复发率方面优于甲硝唑组。3.止带方加味联合甲硝唑片治疗湿热下注型BV疗效确切,无明显不良反应。
[Abstract]:Objective: to observe the changes of clinical symptoms and laboratory indexes of vaginal secretions after treatment of bacterial vaginosis (bacterial vaginosis,BV) with Zhibanfang decoction. So as to evaluate the clinical efficacy of Zhibanfang Jiawei in the treatment of bacterial vaginosis caused by dampness and heat. Methods: 66 patients with BV were randomly divided into treatment group (n = 33) and control group (n = 33). In the course of the study, one patient in the control group dropped off due to late oral administration. The treatment group was treated with Zhibai prescription and metronidazole tablets, and the control group with metronidazole tablets. After 1 week of treatment and 1 week of withdrawal, the vaginal secretions of the patients were reexamined, the symptoms of TCM and local signs of gynecological examination were re-evaluated, and the patients were followed up for 2 menstrual cycles. The result is 1: 1. Compared with the two groups, the cure rate of the treatment group was higher than that of the control group, the difference was statistically significant (P0.05), the total curative effect of the two groups had no statistical significance compared with the control group (P0.05). Treatment group can significantly improve the symptoms of traditional Chinese medicine patients, compared with the treatment before the difference was statistically significant (P0.05), compared with the control group was better than the control group, the difference was statistically significant (P0.05). The treatment group can obviously improve the vaginal secretion of patients "cleanliness", "clue cells", "amines test", "PH value", compared with the treatment before the difference was statistically significant (P0.05). The treatment group in improving vaginal discharge "cleanliness" than the control group, the difference was statistically significant (P0.05). There was no significant difference between the two groups in improving the other three items (P0.05). The treatment group can obviously improve the local signs of gynecological examination of patients, compared with the treatment before the difference was statistically significant (P0.05), compared with the control group, the difference was not statistically significant (P0.05). During the follow-up, the treatment group was superior to the control group in recovering Lactobacillus vaginalis and reducing the recurrence rate, the difference was statistically significant (P0.05). The safety indexes of the treatment group were normal before and after treatment, and no obvious adverse reactions occurred. Conclusion: 1. Zhibanfang plus metronidazole tablets can improve the clinical symptoms and signs of patients, improve the vaginal discharge laboratory examination indicators. 2. Zhibanfang plus metronidazole tablet is superior to metronidazole group in improving TCM symptoms, improving vaginal discharge cleanliness, restoring lactobacillus vaginalis and reducing recurrence rate. Zhibanfang plus metronidazole tablet was effective in the treatment of BV with dampness and heat.
【学位授予单位】:黑龙江中医药大学
【学位级别】:硕士
【学位授予年份】:2017
【分类号】:R271.9

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