三伏灸不同灸量对支气管哮喘新西兰兔细支气管形态的影响

发布时间：2018-10-30 17:13

【摘要】：目的:观察三伏灸治疗过程中不同灸量对支气管哮喘(BA)新西兰兔的胸部温度及肺细支气管组织形态结构的影响。方法:选取新西兰雄性兔子30只,随机分为5组:模型(A)组、空白(B)组、对照(C)组、实验(D)组、地塞米松(E)组。进行BA气道重塑模型造模后,于"三伏天"以隔姜灸加中药贴敷法干预,并使用红外热象仪进行胸部温度监测。疗程结束后,取新西兰兔右肺,HE染色观察对比不同组新西兰兔右肺细支气管形态结构的变化情况。结果:干预后,其余4组细支气管内管壁及平滑肌厚度较B组厚(P0.05);A组与C组支气管内管壁及平滑肌厚度无明显差异;A组细支气管内管壁及平滑肌厚度较D、E组厚(P0.05)。D组的胸腔体表温度明显高于灸前(P0.05);C组的胸腔体表温度与灸前无明显差异;D组温度变化幅度明显大于C组(P0.05);胸腔体表温度随着隔姜灸壮数的升高而升高,Spearman相关系数=0.168,P=0.001,差异具有统计学意义。结论:隔姜灸达到9壮能使BA型新西兰兔细支气管形态结构发生良性变化,从而改善BA型新西兰兔气道重塑的症状,有效缓解BA的症状。胸腔体表温度与隔姜灸的量呈正相关,说明胸腔温度的提升可能与疗效有关,温度的提升可能是隔姜灸时达到"气至病所"的相关指标之一。
[Abstract]:Objective: to observe the effect of different moxibustion amount on chest temperature and bronchioles of (BA) New Zealand rabbits with asthma. Methods: thirty New Zealand male rabbits were randomly divided into 5 groups: model (A) group, blank (B) group, control (C) group, experimental (D) group and dexamethasone (E) group. After the model of BA airway remodeling model was made, Ginger-separated moxibustion and traditional Chinese medicine application were used to intervene in "three volts", and the chest temperature was monitored by infrared thermograph. After the course of treatment, the right lung of New Zealand rabbits was taken and the changes of bronchioles in different groups were observed by HE staining. Results: after intervention, the thickness of bronchiole wall and smooth muscle in the other four groups was thicker than that in group B (P0.05). There was no significant difference in the thickness of intrabronchial wall and smooth muscle between); A group and C group. The thickness of bronchiole wall and smooth muscle in group A was thicker than that in group D (P0.05). The surface temperature of thoracic cavity in). D group was significantly higher than that before moxibustion (P0.05). There was no significant difference between); C group and pre-moxibustion group. The temperature of group D was significantly larger than that of group C (P0.05), and the surface temperature of thoracic cavity increased with the increase of the number of ginger separated moxibustion, the correlation coefficient of Spearman was 0.168 Pao 0.001, the difference was statistically significant. Conclusion: Ginger-separated moxibustion can improve the airway remodeling symptoms of BA New Zealand rabbits and relieve the symptoms of BA effectively by making benign changes in bronchiole morphology of BA New Zealand rabbits. There was a positive correlation between the surface temperature of thoracic cavity and the quantity of ginger separated moxibustion, which indicated that the increase of chest temperature might be related to the curative effect, and the increase of temperature might be one of the related indexes to achieve the "Qi to disease" in ginger separated moxibustion.
【作者单位】：福建省中医药研究院;
【基金】：国家自然科学基金项目(No.81403490) 福建省经络感传重点实验室,福建省科技厅项目(No.2015R1035-3) 福建省卫生厅课题(No.2014-ZQN-JC-33)~~
【分类号】：R245

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