独活寄生合剂治疗肝肾不足型膝骨关节炎的临床疗效观察

发布时间：2018-11-01 12:01

【摘要】：目的:临床上我们运用独活寄生合剂治疗肝肾不足型膝骨关节炎,观察其临床疗效及安全性。按照随机临床分组对照研究,观察口服中药方剂独活寄生合剂加西药联合(治疗组)与单纯口服西药组(对照组)对骨关节炎的疼痛、关节功能以及中医证候改善情况,并通过检测患者血清中超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)、白细胞介素-1(interleukin-1,IL-1)两者治疗前后浓度变化情况,评价独活寄生合剂在临床上对治疗肝肾不足型膝骨关节炎的有效性及安全性。方法:对60例确诊为膝骨关节炎(knee osteoarthritis,KOA)的肝肾不足型患者进行血液检测,临床随机配对分组。重点观察治疗前后对照组、以及治疗组的KOA患者血液中hs-CRP、IL-1化验指标变化以及膝骨关节的疼痛、关节功能及中医证候改善情况。资料经过汇总后,通过SPSS 21统计软件分析结果有无统计学意义。结果:在最终纳入的60例总样本中,对治疗前的两组间性别、年龄、体重指数、患膝X线分级进行比较,都无统计学意义(P0.05),具有可比性。疗程结束后,两组间有效率比较,治疗组优于对照组(P0.05);两组治疗前后中医证候积分、WOMAC评分以及hs-CRP、IL-1浓度均有不同程度下降,差异有意义(P0.05),其中治疗组明显优于对照组,差异有统计学意义(P0.05)。可以看出在缓解疼痛,改善关节功能活动方面,治疗组明显优于对照组。治疗前后两组WBC、Hb、ALT、AST、Cr、BUN均无明显变化(P0.05),两组药物无明显副作用,安全性良好。结论:通过对总样本量的分析可以看到肝肾不足型KOA的发病与年龄、性别、体重指数有着重要的关系,KOA好发于中老年人群,其中女性的数量显著大于男性,体重与膝骨关节炎存在一定联系。独活寄生合剂能够有效的控制肝肾不足型KOA患者的临床症状,缓解膝关节疼痛,改善活动功能,联合西药治疗取得的效果更加显著。且治疗中独活寄生合剂无明显毒副作用,安全性高。
[Abstract]:Objective: to observe the clinical efficacy and safety of Duhuo parasitic mixture in treating knee osteoarthritis with deficiency of liver and kidney. According to the randomized and controlled clinical study, the pain, joint function and syndromes of traditional Chinese medicine prescription Duhuo parasitic mixture combined with western medicine (treatment group) and oral western medicine group (control group) on osteoarthritis were observed. The changes of serum concentrations of hypersensitive C-reactive protein,hs-CRP and interleukin-1,IL-1 were measured before and after treatment. To evaluate the efficacy and safety of Duhuo parasitic mixture in the treatment of knee osteoarthritis with deficiency of liver and kidney. Methods: 60 patients with knee osteoarthritis (knee osteoarthritis,KOA) were divided into two groups randomly. The changes of hs-CRP,IL-1 in blood of KOA patients before and after treatment and the improvement of knee joint pain, joint function and TCM syndromes were observed. The data were collected and analyzed by SPSS 21 software. Results: there was no significant difference in sex, age, body mass index and knee X-ray grading between the two groups before treatment (P0.05). After the course of treatment, the effective rate between the two groups, the treatment group was better than the control group (P0.05); Before and after treatment, the TCM syndromes score, WOMAC score and hs-CRP,IL-1 concentration in the two groups were decreased to varying degrees, the difference was significant (P0.05), the treatment group was significantly better than the control group, the difference was statistically significant (P0.05). It can be seen that the treatment group is superior to the control group in relieving pain and improving joint function. There was no significant change in WBC,Hb,ALT,AST,Cr,BUN in both groups before and after treatment (P0.05), and the two groups had no obvious side effects and good safety. Conclusion: by analyzing the total sample size, we can see that there is an important relationship between the incidence of KOA and age, sex, body mass index. The incidence of KOA is more common in middle-aged and elderly people, and the number of female is significantly larger than that of male. Weight and knee osteoarthritis have a certain relationship. Duhuo parasitic mixture can effectively control the clinical symptoms of KOA patients with liver and kidney deficiency, relieve knee pain, improve activity function, and the effect of combined western medicine treatment is more remarkable. And the treatment of Duhuo parasitic mixture has no obvious side effects, high safety.
【学位授予单位】：云南中医学院
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R274.9

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