基于系统药理学平台解析中药复方治疗白癜风的作用机制

发布时间：2018-11-01 18:55

【摘要】：白癜风是一种色素脱失性皮肤疾病,主要是由于黑素细胞的减少引发的,由于其皮损常发生在暴露部位,因此给病人带来容貌和心理方面的损害,影响了世界上1-4%的人口的身心健康。目前,白癜风发病机制尚不明确,导致它成为一种易诊断难治疗的疾病。传统中草药具有多成分多靶点的特点,在治疗白癜风中拥有悠久的临床实践,但是这些中药的活性分子,作用靶标以及治疗白癜风的分子机制都尚不明确。在本研究中,我们基于临床上有效的中药复方驱白巴布期为例,利用系统药理学方法探索传统中药治疗白癜风的分子机制。我们首先通过药代动力学系统筛选出复方驱白巴布期的活性成分,然后利用加权系综相似度法预测出活性分子作用的靶标,最后综合分析分子-靶标,靶标-通路以及整合白癜风通路网络来揭示中药复方治疗白癜风的潜在分子机制。结果表明,复方驱白巴布期中存在56个活性成分以协同的方式作用于83个靶标并且这些靶标主要参与了调节机体免疫系统平衡,调控黑色素细胞黑素分泌以及调节神经功能系统平衡这三种生物学过程。本研究基于中药系统药理学方法阐明了复方驱白巴布期治疗白癜风的复杂分子机制,这一研究促进了传统中药在现代医药中的应用。
[Abstract]:Vitiligo is a pigmented loss of skin disease, mainly caused by the reduction of melanocytes, because its skin lesions often occur in the exposed site, so to the patient's appearance and psychological damage, It affects the physical and mental health of 1-4% of the world's population. At present, the pathogenesis of vitiligo is not clear, which makes it easy to diagnose and treat. Traditional Chinese herbal medicine has the characteristics of multi-component and multi-target, and has a long clinical practice in the treatment of vitiligo, but the active molecules, the target of action and the molecular mechanism of the treatment of vitiligo are not clear. In this study, we investigated the molecular mechanism of traditional Chinese medicine in the treatment of vitiligo by systematic pharmacological method based on the clinical effective Chinese medicine compound in the treatment of vitiligo. At first, the active components of the compound flooding were screened out by pharmacokinetic system, then the target of active molecules was predicted by weighted ensemble similarity method, and the molecular target was analyzed synthetically. Target-pathway and integrated vitiligo pathway network to reveal the potential molecular mechanism of traditional Chinese medicine in the treatment of vitiligo. The results showed that 56 active components acted on 83 targets in a synergistic manner and these targets were mainly involved in regulating the balance of immune system. Regulation of melanocyte melanin secretion and regulation of neural functional system balance these three biological processes. Based on the systematic pharmacological method of Chinese medicine, this study elucidated the complex molecular mechanism of the treatment of vitiligo with compound displacing palmitage, which promoted the application of traditional Chinese medicine in modern medicine.
【学位授予单位】：西北大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R275.9

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