通脉养心丸治疗稳定型心绞痛的临床疗效观察及对BNP、hs-cTnT的影响
发布时间：2018-11-02 11:03
【摘要】：目的：观察通脉养心丸治疗冠心病稳定型心绞痛(气阴两虚型)患者的临床疗效及对BNP、hs-cTnT水平的影响,进一步评价其有效性,并初步探讨其对心肌损伤修复作用的影响,为扩大临床应用提供疗效性依据。方法：选取黑龙江中医药大学附属第一医院心血管二科和心血管四科门诊患者中符合标准及签署知情同意书的患者20例,采用随机、双盲、安慰剂对照的研究方法,将入选患者按1：1随机分为试验组和对照组,试验组予以西医标准治疗+通脉养心丸,每次40粒,每日2次；对照组予以西医标准治疗+安慰剂,每次40粒,每日2次；疗程均为12周。观察治疗前、治疗后的中医证候变化、心电图变化及BNP、hs-cTnT水平的变化。结果：1.中医证候方面：治疗后,两组患者的中医证候积分均较治疗前明显下降,组内的差异具有统计学意义(p0.05)；试验组的总积分下降程度明显优于对照组,两组间的差异有统计学意义(p0.05)。治疗后,试验组的中医证候总有效率为87.5%,对照组的总有效率为33.3%,两组间的疗效差异具有统计学意义(p0.05)。2.心电图方面：治疗后,试验组的心电图总有效率为75.0%,对照组的心电图总有效率为33.3%,试验组明显优于对照组,两组间的疗效差异具有统计学意义(p0.05)。3.BNP和hs-cTnT方面：治疗后,两组患者的BNP较治疗前均未见明显改变,组内的差异无统计学意义(p0.05),试验组与对照组相比较,两组间的差异无统计学意义(p0.05)。治疗后,两组患者的hs-cTnT较治疗前均未见明显改变,组内的差异无统计学意义(p0.05),试验组与对照组相比较,两组间的差异无统计学意义(p0.05)。结论：1.通脉养心丸可明显改善冠心病稳定型心绞痛(气阴两虚型)患者的中医证候。2.通脉养心丸对冠心病稳定型心绞痛(气阴两虚型)患者心电图的缺血性改变具有明显的改善作用。3.通脉养心丸对冠心病稳定型心绞痛(气阴两虚型)患者的BNP、hs-cTnT的变化未见明显影响。
[Abstract]:Objective: to observe the clinical effect of Tongmai Yangxin pill (Tongmai Yangxin pill) on stable angina pectoris (deficiency of Qi and Yin) of coronary heart disease (CHD) and its effect on BNP,hs-cTnT level, to further evaluate its effectiveness, and to explore the effect of Tongmai Yangxin pill on the repair of myocardial injury. To provide curative effect basis for expanding clinical application. Methods: twenty outpatients from the second and fourth departments of Cardiovascular Department and Cardiovascular Department of the first affiliated Hospital of Heilongjiang University of traditional Chinese Medicine were selected and 20 patients who signed the informed consent were studied by randomized, double-blind, placebo controlled study. The patients were randomly divided into experimental group and control group according to 1:1. The experimental group was treated with western medicine standard Tongmai Yangxin pills, 40 pills each time, twice a day; The control group was treated with western medicine standard placebo, 40 tablets twice a day, the course of treatment was 12 weeks. The changes of TCM syndromes, electrocardiogram and BNP,hs-cTnT level before and after treatment were observed. Results: 1. TCM syndromes: after treatment, the scores of TCM syndromes in the two groups were significantly lower than those before treatment, and the differences in the two groups were statistically significant (p0.05). The decrease of the total score in the test group was significantly better than that in the control group, and the difference between the two groups was statistically significant (p0.05). After treatment, the total effective rate of TCM syndromes in the experimental group was 87.5 and that in the control group was 33.3.The difference between the two groups was statistically significant (p0.05). 2. Electrocardiogram: after treatment, the total effective rate of electrocardiogram in the experimental group was 75.0, and that in the control group was 33.30.The experimental group was obviously superior to the control group. The difference of curative effect between the two groups was statistically significant (p0.05). 3.BNP and hs-cTnT: after treatment, the BNP of the two groups had no significant change compared with that before treatment, and there was no significant difference between the two groups (p0.05). There was no significant difference between the two groups compared with the control group (p 0.05). After treatment, there was no significant change in hs-cTnT between the two groups. There was no significant difference between the two groups (p0. 05), and there was no significant difference between the two groups (p0. 05). Conclusion 1. Tongmai Yangxin pills can obviously improve the TCM syndromes of patients with stable angina pectoris of coronary heart disease (deficiency of Qi and Yin). 2. 2. Tongmai Yangxin pills can improve the ischemic changes of ECG in patients with stable angina pectoris of coronary heart disease (deficiency of both qi and yin). 3. Tongmai Yangxin pill had no obvious effect on BNP,hs-cTnT in patients with stable angina pectoris of coronary heart disease (deficiency of Qi and Yin).
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259
本文编号：2305829
[Abstract]:Objective: to observe the clinical effect of Tongmai Yangxin pill (Tongmai Yangxin pill) on stable angina pectoris (deficiency of Qi and Yin) of coronary heart disease (CHD) and its effect on BNP,hs-cTnT level, to further evaluate its effectiveness, and to explore the effect of Tongmai Yangxin pill on the repair of myocardial injury. To provide curative effect basis for expanding clinical application. Methods: twenty outpatients from the second and fourth departments of Cardiovascular Department and Cardiovascular Department of the first affiliated Hospital of Heilongjiang University of traditional Chinese Medicine were selected and 20 patients who signed the informed consent were studied by randomized, double-blind, placebo controlled study. The patients were randomly divided into experimental group and control group according to 1:1. The experimental group was treated with western medicine standard Tongmai Yangxin pills, 40 pills each time, twice a day; The control group was treated with western medicine standard placebo, 40 tablets twice a day, the course of treatment was 12 weeks. The changes of TCM syndromes, electrocardiogram and BNP,hs-cTnT level before and after treatment were observed. Results: 1. TCM syndromes: after treatment, the scores of TCM syndromes in the two groups were significantly lower than those before treatment, and the differences in the two groups were statistically significant (p0.05). The decrease of the total score in the test group was significantly better than that in the control group, and the difference between the two groups was statistically significant (p0.05). After treatment, the total effective rate of TCM syndromes in the experimental group was 87.5 and that in the control group was 33.3.The difference between the two groups was statistically significant (p0.05). 2. Electrocardiogram: after treatment, the total effective rate of electrocardiogram in the experimental group was 75.0, and that in the control group was 33.30.The experimental group was obviously superior to the control group. The difference of curative effect between the two groups was statistically significant (p0.05). 3.BNP and hs-cTnT: after treatment, the BNP of the two groups had no significant change compared with that before treatment, and there was no significant difference between the two groups (p0.05). There was no significant difference between the two groups compared with the control group (p 0.05). After treatment, there was no significant change in hs-cTnT between the two groups. There was no significant difference between the two groups (p0. 05), and there was no significant difference between the two groups (p0. 05). Conclusion 1. Tongmai Yangxin pills can obviously improve the TCM syndromes of patients with stable angina pectoris of coronary heart disease (deficiency of Qi and Yin). 2. 2. Tongmai Yangxin pills can improve the ischemic changes of ECG in patients with stable angina pectoris of coronary heart disease (deficiency of both qi and yin). 3. Tongmai Yangxin pill had no obvious effect on BNP,hs-cTnT in patients with stable angina pectoris of coronary heart disease (deficiency of Qi and Yin).
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259
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