补阳还五汤加减治疗气虚血瘀型难治性斑秃的临床疗效观察

发布时间：2018-11-02 15:15

【摘要】：目的:观察补阳还五汤加减治疗气虚血瘀型难治性斑秃的临床疗效,并探讨皮肤镜在脱发类疾病中的运用前景。方法:将72例气虚血瘀型难治性斑秃患者,随机分为两组。治疗组(36例)口服补阳还五汤加减,对照组(36例)口服复方甘草酸苷片,两组在治疗期间均联合梅花针叩刺。运用皮肤镜对纳入观察的气虚血瘀型难治性斑秃患者进行临床疗效的微观观察。以4周为一个观察疗程,分别于治疗前及治疗后第4周、8周、12周末填写疗效观察表,并用SPSS 22.0对数据进行统计学分析判定疗效。结果:1皮损积分:治疗前治疗组与对照组皮损积分比较差异无统计学意义,具有可比性。经3个疗程(12周)治疗,治疗组治疗后皮损积分为6.11±3.503较治疗前皮损积分11.08±3.093明显降低;对照组治疗后积分为8.34±5.218较治疗前皮损积分10.94±2.947明显降低;并对治疗组与对照组组间比较,差异具有统计学意义(P0.05),治疗组在改善皮损评分上效果明显优于对照组。2临床疗效:经3个疗程(12周)治疗后,治疗组痊愈3例,显效15例,有效13例,无效5例,总有效率86.11%;对照组痊愈1例,显效11例,有效9例,总有效率60.00%。治疗组有效率明显高于对照组,差异均有统计学意义。3皮肤镜微观疗效观察:两组患者经皮肤镜下观察,治疗前终毛数密度的差异无统计学意义;治疗组治疗4周、8周及12周后的终毛数密度均高于对照组,差异均有统计学意义。结论:1补阳还五汤加减联合梅花针叩刺对气虚血瘀型难治性斑秃有确切的疗效,为临床难治性斑秃的辨证施治提供了新的思路与方法。2补阳还五汤加减治疗气虚血瘀型难治性斑秃的疗效优于复方甘草酸苷片。3皮肤镜在脱发类疾病的临床疗效评估上具有广阔的应用前景。
[Abstract]:Objective: to observe the clinical effect of Buyang Huanwu decoction in treating refractory alopecia areata with Qi deficiency and blood stasis, and to explore the application prospect of dermatoscope in alopecia. Methods: 72 patients with refractory alopecia areata with qi deficiency and blood stasis were randomly divided into two groups. The treatment group (36 cases) was treated with Buyang Huanwu decoction and the control group (36 cases) with compound glycyrrhizin tablets. The clinical efficacy of refractory alopecia areata with deficiency of qi and blood stasis was observed with dermatoscope. After 4 weeks of treatment as a course of treatment, we filled out the observation form before treatment and at the end of 4th, 8th and 12th week after treatment, and evaluated the curative effect by statistical analysis of data with SPSS 22. 0. Results: 1 the score of skin lesion: there was no significant difference between the treatment group and the control group before treatment. After 3 courses of treatment (12 weeks), the score of skin lesion in the treatment group was 6.11 卤3.503, which was significantly lower than that before treatment (11.08 卤3.093). In the control group, the score after treatment was 8.34 卤5.218, which was significantly lower than that before treatment (10.94 卤2.947). The difference between the treatment group and the control group was statistically significant (P0.05). The effect of the treatment group in improving the score of skin lesions was significantly better than that in the control group. 2 Clinical efficacy: after three courses of treatment (12 weeks), 3 cases in the treatment group were cured. There were 15 cases of remarkable effect, 13 cases of effective and 5 cases of ineffective. The total effective rate was 86.11%. In the control group, 1 case was cured, 11 cases were effective, 9 cases were effective, the total effective rate was 60.00g. The effective rate of the treatment group was significantly higher than that of the control group, and the difference was statistically significant. 3 observation of microscopic curative effect of dermatoscope: there was no significant difference in the number of hair density before treatment between the two groups. After 4 weeks, 8 weeks and 12 weeks of treatment, the end hair density in the treatment group was significantly higher than that in the control group. Conclusion: (1) Buyang Huanwu decoction combined with plum blossom acupuncture has definite curative effect on refractory alopecia areata with deficiency of qi and blood stasis. 2 the curative effect of Buyang Huanwu decoction in treating refractory alopecia areata with Qi deficiency and blood stasis is better than that of compound glycyrrhizin tablet. 3 the clinical effect of dermatoscope in alopecia is better than that of compound glycyrrhizin tablets. The evaluation of curative effect has broad application prospect.
【学位授予单位】：云南中医学院
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R275.9

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