定经汤味联合加宫腔镜防治肾虚血瘀型EPs的临床研究
发布时间：2018-11-02 20:03
【摘要】：目的：通过观察中药定经汤加味对肾虚血瘀型子宫内膜息肉宫腔镜术后患者的月经、中医证候、息肉复发情况的作用,评价中药在防治子宫内膜息肉方面的效果及临床优势。方法：收集符合纳入标准的94例病例,随机分为中药组31例、西药组32例和对照组31例。中药组于宫腔镜术后每次月经周期第8天开始服用中药定经汤加味,连续服用14天(手术当月,术后即开始服用),西药组于宫腔镜术后每次月经周期第16天开始服用地屈孕酮片(手术当月亦按周期服用),连续服用10天,每个月经周期为1个疗程,共治疗3个疗程；对照组为单纯的手术组。通过记录患者的中医证候、子宫内膜厚度以及子宫内膜息肉复发情况,评价各组患者术后第3个月经周期及第6个月经周期的调经效果、临床疗效。最后将记录的数据通过SPSS17.0软件包进行统计学分析。结果：1.宫腔镜手术前,三组患者的年龄、中医主要症状积分、次要症状积分、症状总积分、病情分布及子宫内膜厚度,经统计学分析无显著性差异(P0.05),说明三组之间符合统计学分析要求,具有组间可比性。2.中医主证积分比较：三组在治疗3个疗程后,差异有统计学意义(P0.05),组间两两比较差异无统计学意义(P0.05)；停药3个疗程后,差异有统计学意义(P0.05),通过两两对比,中药组和对照组、西药组和对照组之间差异有统计学意义(P0.05)。数据表明,三组皆可改善患者的月经情况,观察时间越长,中药组效果越好。3.中医次证积分比较：三组在治疗3个疗程后及停药3个疗程后,组间差异均有统计学意义(P0.05)。数据表明,中药组在改善次要症状方面优于西药组和对照组,且效果稳定。4.中医证候总积分比较：三组在治疗3个疗程后及停药3个疗程后,差异有统计学意义(P0.05)；通过组间两两对比,中药组和对照组、西药组和对照组之间差异有统计学意义(P0.05)；三组在治疗后与停药后组内比较,无统计学意义(P0.05)。数据表明,三组中医症状均有改善,但治疗后与停药后组内差异不明显,若延长观察时间,则中药组在改善中医证候方面疗效更持久。5.子宫内膜厚度比较：三组在治疗3个疗程后,中药组和对照组、西药组和对照组之间差异有统计学意义(P0.05)；停药3个疗程后,三组之间差异均有统计学意义(P0.05)；三组在治疗后与停药后组内比较,西药组与对照组组内差异明显(P0.05)。数据表明,三组皆可抑制子宫内膜异常增厚,且中药组效果最明显,且疗效持久。6.临床疗效比较：三组在治疗3个疗程及停药3个疗程后,差异有统计学意义(P0.05)。通过两两对比,中药组和对照组、西药组和对照组之间差异有统计学意义(P0.05)。数据表明,在目前观察时间内,中药组与西药组效果相当,且皆优于对照组。7.复发率比较：三组于治疗3个疗程内均无复发；停药3个疗程内共复发6例,总复发率为7.78%。其中西药组复发1例,复发率为3.33%,对照组复发5例,复发率为16.67%。通过统计学分析,三组间的复发率有统计学意义(P0.05),但两两比较无明显差异(P0.05)。结论：1-中药定经汤加味可显著改善肾虚血瘀型子宫内膜息肉患者宫腔镜术后月经情况及中医证候。2.中药定经汤加味可明显抑制子宫内膜厚度,降低子宫内膜息肉复发率。3.中药定经汤加味在治疗肾虚血瘀型子宫内膜息肉宫腔镜术后患者时无明显不良反应,值得在临床上推广使用。
[Abstract]:Objective: To evaluate the effect and clinical advantage of traditional Chinese medicine on the prevention and treatment of endometrial polyps by observing the effect of traditional Chinese medicine on menstruation, syndrome of TCM syndrome and recurrence of polyps after hysteroscopy of endometrial polyps with kidney deficiency and blood stasis. Methods: Ninety-four cases were randomly divided into 31 cases of Chinese medicine group, 32 cases of western medicine group and 31 cases of control group. The traditional Chinese medicine group started taking the traditional Chinese medicine at the 8th day of each menstrual cycle after the hysteroscope, and the traditional Chinese medicine is continuously taken for 14 days (the operation month, the operation is started after the operation), On the 16th day of each menstrual cycle after hysteroscopy, the western medicine group began to take the dydroxyprogesterone tablet (also taken periodically in the same month) for 10 days, each menstrual cycle was 1 course of treatment, and the control group was a simple group of surgery. By recording the patient's syndrome of TCM syndrome, the thickness of endometrium and the recurrence of endometrial polyps, the effects of menstruation regulating effect and clinical efficacy of the third menstrual cycle and the 6th menstrual cycle in each group were evaluated. Finally, the recorded data were analyzed statistically by SPSS 10.0 software package. Result: 1. Before hysteroscopy, the age of three groups, the integration of traditional Chinese medicine, the integral of secondary symptoms, the total score of symptoms, the distribution of disease and the thickness of endometrium were not significant (P0.05). After 3 courses of treatment, there was no significant difference between the two groups (P0.05), and the difference was statistically significant after 3 treatment courses (P0.05). There was significant difference between the western medicine group and the control group (P0.05). Data showed that three groups could improve the menstruation of the patients, the longer the observation time, the better the effect of the traditional Chinese medicine group. After 3 courses of treatment and 3 treatment courses, the difference between the groups was statistically significant (P0.05). The data show that the traditional Chinese medicine group is superior to the western medicine group and the control group in improving the secondary symptoms, and the effect is stable. There was a significant difference in the difference between the two groups (P <0.05) and the control group (P <0.05). There was no significant difference between the three groups after treatment and in the group after drug withdrawal (P0.05). The data showed that the symptoms of the three groups were improved, but the difference between the treatment group and the group after discontinuation was not obvious, and if the observation time was prolonged, the curative effect of the traditional Chinese medicine group on improving the syndrome of traditional Chinese medicine was more durable. Compared with the control group, the difference between the western medicine group and the control group was statistically significant (P0.05). There was no significant difference between the western medicine group and the control group (P0.05). The data showed that the abnormal thickening of endometrium was inhibited in three groups, and the effect of traditional Chinese medicine group was most obvious and the curative effect was durable. The difference was statistically significant after 3 courses of treatment and 3 treatment courses (P0.05). The difference between the two groups, the control group, the western medicine group and the control group was statistically significant (P0.05). The data showed that in the current observation time, the effect of the traditional Chinese medicine group and the western medicine group was comparable and better than that of the control group. The recurrence rate was compared: there was no recurrence within 3 courses of treatment, 6 cases were recurred in 3 courses of treatment, and the total recurrence rate was 7.78%. The recurrence rate was 3.33% in western medicine group, 5 in control group and 16.67% in control group. Statistical analysis showed that the recurrence rate among the three groups was statistically significant (P0.05), but there was no significant difference between the two groups (P0.05). Conclusion: 1-Chinese medicine can significantly improve the menstruation and TCM syndrome after hysteroscopy in patients with endometrial polyps with kidney deficiency and blood stasis. Traditional Chinese medicine can significantly inhibit the endometrial thickness and reduce the recurrence rate of endometrial polyps. The traditional Chinese medicine has no obvious adverse reaction in treating patients with renal deficiency and blood stasis type endometrial polyps after hysteroscopy, and is worthy of being popularized and used clinically.
【学位授予单位】：广州中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R271.9
本文编号：2306818
[Abstract]:Objective: To evaluate the effect and clinical advantage of traditional Chinese medicine on the prevention and treatment of endometrial polyps by observing the effect of traditional Chinese medicine on menstruation, syndrome of TCM syndrome and recurrence of polyps after hysteroscopy of endometrial polyps with kidney deficiency and blood stasis. Methods: Ninety-four cases were randomly divided into 31 cases of Chinese medicine group, 32 cases of western medicine group and 31 cases of control group. The traditional Chinese medicine group started taking the traditional Chinese medicine at the 8th day of each menstrual cycle after the hysteroscope, and the traditional Chinese medicine is continuously taken for 14 days (the operation month, the operation is started after the operation), On the 16th day of each menstrual cycle after hysteroscopy, the western medicine group began to take the dydroxyprogesterone tablet (also taken periodically in the same month) for 10 days, each menstrual cycle was 1 course of treatment, and the control group was a simple group of surgery. By recording the patient's syndrome of TCM syndrome, the thickness of endometrium and the recurrence of endometrial polyps, the effects of menstruation regulating effect and clinical efficacy of the third menstrual cycle and the 6th menstrual cycle in each group were evaluated. Finally, the recorded data were analyzed statistically by SPSS 10.0 software package. Result: 1. Before hysteroscopy, the age of three groups, the integration of traditional Chinese medicine, the integral of secondary symptoms, the total score of symptoms, the distribution of disease and the thickness of endometrium were not significant (P0.05). After 3 courses of treatment, there was no significant difference between the two groups (P0.05), and the difference was statistically significant after 3 treatment courses (P0.05). There was significant difference between the western medicine group and the control group (P0.05). Data showed that three groups could improve the menstruation of the patients, the longer the observation time, the better the effect of the traditional Chinese medicine group. After 3 courses of treatment and 3 treatment courses, the difference between the groups was statistically significant (P0.05). The data show that the traditional Chinese medicine group is superior to the western medicine group and the control group in improving the secondary symptoms, and the effect is stable. There was a significant difference in the difference between the two groups (P <0.05) and the control group (P <0.05). There was no significant difference between the three groups after treatment and in the group after drug withdrawal (P0.05). The data showed that the symptoms of the three groups were improved, but the difference between the treatment group and the group after discontinuation was not obvious, and if the observation time was prolonged, the curative effect of the traditional Chinese medicine group on improving the syndrome of traditional Chinese medicine was more durable. Compared with the control group, the difference between the western medicine group and the control group was statistically significant (P0.05). There was no significant difference between the western medicine group and the control group (P0.05). The data showed that the abnormal thickening of endometrium was inhibited in three groups, and the effect of traditional Chinese medicine group was most obvious and the curative effect was durable. The difference was statistically significant after 3 courses of treatment and 3 treatment courses (P0.05). The difference between the two groups, the control group, the western medicine group and the control group was statistically significant (P0.05). The data showed that in the current observation time, the effect of the traditional Chinese medicine group and the western medicine group was comparable and better than that of the control group. The recurrence rate was compared: there was no recurrence within 3 courses of treatment, 6 cases were recurred in 3 courses of treatment, and the total recurrence rate was 7.78%. The recurrence rate was 3.33% in western medicine group, 5 in control group and 16.67% in control group. Statistical analysis showed that the recurrence rate among the three groups was statistically significant (P0.05), but there was no significant difference between the two groups (P0.05). Conclusion: 1-Chinese medicine can significantly improve the menstruation and TCM syndrome after hysteroscopy in patients with endometrial polyps with kidney deficiency and blood stasis. Traditional Chinese medicine can significantly inhibit the endometrial thickness and reduce the recurrence rate of endometrial polyps. The traditional Chinese medicine has no obvious adverse reaction in treating patients with renal deficiency and blood stasis type endometrial polyps after hysteroscopy, and is worthy of being popularized and used clinically.
【学位授予单位】：广州中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R271.9
【参考文献】
相关期刊论文 前10条
1 韩凤娟;董应男;王秀霞;;王秀霞教授治疗肾虚血瘀型不孕症的临床经验[J];中医药信息;2016年02期
2 严宇仙;王谦信;何晓燕;;何氏血竭消聚汤加减治疗妇科囊胞型ve瘕82例[J];中国中医药科技;2015年05期
3 田荣;;宫腔镜子宫内膜息肉切除术后配合激素治疗的效果研究[J];中国医学装备;2015年06期
4 鲁改娟;夏亲华;;子宫内膜息肉中西医研究进展[J];辽宁中医药大学学报;2015年01期
5 陈静鸽;;宫腔镜治疗子宫内膜息肉合并不孕症患者临床分析[J];中外医疗;2014年34期
6 朱瑜;黄小萍;邵敬於;;孕激素的临床药理基础[J];世界临床药物;2014年11期
7 刘娜;吴苗敏;伊江燕;蔡霞;;少腹逐瘀汤加减对宫腔镜子宫内膜息肉切除术后的预防复发作用[J];中药材;2014年09期
8 刘艳俊;杨静;;中西医结合干预育龄期子宫内膜息肉术后临床观察[J];山西中医;2014年10期
9 王明珍;皮冰;;去氧孕烯炔雌醇(妈富隆)预防子宫内膜息肉术后复发的比较研究[J];中国微创外科杂志;2014年03期
10 黄丽华;向梅;;子宫内膜息肉研究新进展[J];国际妇产科学杂志;2014年01期
相关硕士学位论文 前1条
1 曾奰得;子宫内膜息肉伴经期延长的中医辨证分型和体质调查[D];广州中医药大学;2015年
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