二乌消痹汤治疗寒湿痹阻型膝骨性关节炎的临床观察

发布时间：2018-11-04 20:53

【摘要】：目的:探究二乌消痹汤治疗寒湿痹阻型膝骨性关节炎的疗效和优势,并总结该治法的特点、优点,分析其理论依据,为临床中探索一种疗效确切、安全性高的治疗措施提供科学依据,挖掘中医药治疗KOA的价值。方法:收集20 16年3月至2017年1月黑龙江中医药大学附属一院诊断为寒湿痹阻型膝骨性关节炎的门诊患者62例,按就诊序号使用随机数字表法分为治疗组、对照组各31例。治疗组服用二乌消痹汤,疗程30天;对照组服用金乌骨通胶囊,疗程30天。通过观察两组的一般情况,两组治疗前后在VAS评分、Lequene-Mery膝关节骨性关节炎评分、中医证候评分的变化,对两组临床数据进行统计分析,同时对相关安全性指标及不良反应进行观察记录。结果:1.两组各项观察指标在治疗前后组内比较均具有显著统计学差异(P0.01)。2.两组治疗后在VAS评分、休息痛、运动痛、肿胀、晨僵、行走能力及中医症候的膝关节疼痛、形寒肢重、肿胀、屈伸活动的分值组间比较具有统计学意义(P0.05)。3.治疗组和对照组在临床疗效总有效率分别为86.67%、74.19%,中医证候疗效总有效率分别为86.67%、77.42%。两组在临床疗效判定结果及中医症候疗效判定结果上比较均有显著统计学意义(P0.01),治疗组总疗效优于对照组。4.两组各项常规检查,均无异常变化情况;治疗组出现轻度不良反应2例,不良率为6.67%;对照组出现1例,不良率为3.23%;均自行缓解,未做特殊处置。结论:1.二乌消痹汤在止痛、消肿、改善晨僵、改善膝关节活动及形寒肢重方面疗效优于金乌骨通胶囊。2.二乌消痹汤具有有效率高、疗效显著、不良率低的特点,具有较高的安全性,是治疗寒湿痹阻型KOA的有效方法,值得进一步研究及推广。
[Abstract]:Objective: to explore the curative effect and advantage of Erwuxiaobi decoction in the treatment of knee osteoarthritis with cold dampness and obstruction, summarize the characteristics and advantages of the treatment, analyze its theoretical basis, and explore a kind of effective effect in clinic. The safe treatment provides the scientific basis and excavates the value of traditional Chinese medicine in the treatment of KOA. Methods: from March 2016 to January 2017, 62 outpatients with cold and dampness arthralgia type osteoarthritis of knee were collected and divided into treatment group (n = 31) and control group (n = 31). The treatment group took Erwu Xiaobi decoction for 30 days while the control group took Jinwu Gutong capsule for 30 days. By observing the general situation of the two groups, the changes of VAS score, Lequene-Mery knee osteoarthritis score and TCM syndrome score before and after treatment, the clinical data of the two groups were statistically analyzed. At the same time, the safety indexes and adverse reactions were observed and recorded. The result is 1: 1. There were significant differences between the two groups before and after treatment (P0.01). After treatment, the scores of VAS score, rest pain, motor pain, swelling, morning stiffness, walking ability and TCM symptoms of knee joint pain, cold limb weight, swelling, flexion and extension activity in the two groups were statistically significant (P0.05). The total effective rates of the treatment group and the control group were 86.67 and 74.19 respectively, and the total effective rates of TCM syndrome were 86.67 and 77.42, respectively. There was significant difference between the two groups in clinical curative effect and TCM symptom (P0.01). The total curative effect of the treatment group was better than that of the control group. 4. There were 2 cases of mild adverse reactions in the treatment group and 1 case in the control group, with a rate of 3.23%. Conclusion: 1. Erwuxiaobi decoction is better than Jinwu Gutong capsule in relieving pain, detumescence, improving morning stiffness, improving knee joint movement and weight of cold limb. 2. Erwuxiaobi decoction has the characteristics of high effective rate, remarkable curative effect, low bad rate and high safety. It is an effective method for treating cold and dampness obstruction type KOA, which is worthy of further study and popularization.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R274.9

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