加减桂枝芍药知母汤合益肾除湿丸治疗类风湿性关节炎的疗效观察

发布时间：2018-11-11 10:15

【摘要】：目的探讨加减桂枝芍药知母汤合益肾除湿丸治疗类风湿性关节炎的临床效果。方法选取2014年6月—2015年6月就诊并自愿参与本次研究的类风湿性关节炎患者76例,利用计算机进行随机分组,对照组患者38例,给予甲氨蝶呤片10 mg+双氯芬酸钠75 mg治疗;治疗组患者38例,给予甲氨蝶呤片10 mg+双氯芬酸钠75 mg+加减桂枝芍药知母汤合益肾除湿丸治疗,治疗28 d为1个疗程,治疗3个疗程后,对2组用药效果、关节功能恢复情况及不良反应发生情况进行统计分析,同时测定2组治疗前后血沉(ESR)、类风湿因子(RF)、C反应蛋白(CRP)、免疫球蛋白(Ig G)等理化指标。结果治疗组治疗后关节压痛、关节肿胀、关节活动评分及晨僵时间均优于对照组(P0.05);治疗组治疗后ESR、RF、CRP、Ig G水平均优于对照组(P0.05);治疗组总有效率高于对照组(P0.05);治疗组不良反应发生率低于对照组(P0.05)。结论采取加减桂枝芍药知母汤合益肾除湿丸可促进类风湿性关节炎患者关节功能恢复,且用药安全,值得临床推荐。
[Abstract]:Objective to investigate the clinical effect of the treatment of rheumatoid arthritis by adding and reducing Guizhi Shaoyao Anemarrhena decoction combined with Yishen dehumidification Pill. Methods from June 2014 to June 2015, 76 patients with rheumatoid arthritis were randomly divided into two groups. 38 patients in the control group were treated with methotrexate 10 mg diclofenac sodium 75 mg. 38 patients in the treatment group were treated with methotrexate tablet for 10 mg, diclofenac sodium for 75 mg and Guizhi Shaoyao Anemarrhena decoction combined with Yishen dehumidification pill for 28 days. After 3 courses of treatment, the two groups were treated effectively. The recovery of joint function and the occurrence of adverse reactions were statistically analyzed. The physical and chemical indexes of (ESR), rheumatoid factor (RF), C reactive protein (CRP), immunoglobulin (Ig G) were measured before and after treatment in both groups. Results after treatment, the joint tenderness, joint swelling, joint activity score and morning stiffness time in the treatment group were better than those in the control group (P0.05), the ESR,RF,CRP,Ig G level in the treatment group was better than that in the control group (P0.05). The total effective rate in the treatment group was higher than that in the control group (P0.05), and the incidence of adverse reactions in the treatment group was lower than that in the control group (P0.05). Conclusion the joint function of patients with rheumatoid arthritis can be improved by adding and reducing Guizhi Shaoyao Zhimu decoction combined with Yishen dehumidification Pill, and it is safe to use drugs, which is worthy of clinical recommendation.
【作者单位】：陕西中医药大学;北京中医药大学;
【分类号】：R259

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