通腑逐瘀方治疗支气管哮喘的疗效观察及对FeNO的干预作用

发布时间：2018-11-11 14:15

【摘要】：目的探讨通腑逐瘀方对支气管哮喘患者临床症状积分、中医证候疗效、ACT评分、血清IgE、肺功能、呼出气一氧化氮(FeNO)的影响,初步研究通腑逐瘀方对支气管哮喘发作期的临床疗效及对FeNO的干预情况。方法 1.门诊选取40例支气管哮喘中度发作的患者,随机分为实验组和对照组,每组20例。采集两组患者FeNO值,同时测定患者临床症状积分、证候疗效、ACT评分、血清IgE、肺功能等情况并记录。2.对照组20例患者予布地奈德福莫特罗吸入剂(信必可都保)吸入治疗,一吸／次,一日两次,连续使用3个月；实验组在吸入信必可都保基础上联合通腑逐瘀方口服,治疗持续3个月。疗程结束后再次对患者进行临床症状积分、证候疗效、ACT评分、血清IgE、肺功能、FeNO等采集比较。结果 1.两组患者治疗后FeNO较前降低,症状积分、ACT评分、血清IgE、肺功能亦较治疗前改善,有统计学差异(P0.01)。2.两组间比较,实验组FeNO、血清IgE下降较实验组更显著(P0.01),支气管哮喘症候积分、ACT评分下降较对照组显著(P0.05),肺功能改善与对照组相比差异不明显(P0.05)。结论通腑逐瘀方治疗中度发作支气管哮喘者能降低FeNO,控制气道炎症,在临床症状缓解上优于单纯的激素吸入治疗,在一定程度上体现了中西医结合治疗支气管哮喘的优势,从而实现更多患者对支气管哮喘的控制。
[Abstract]:Objective to investigate the effects of Tongfu Zhuyu recipe on clinical symptom score, TCM syndromes efficacy, ACT score, serum IgE, pulmonary function and exhalation nitric oxide (FeNO) in patients with bronchial asthma. To study the clinical effect of Tongfu Zhuyu recipe on bronchial asthma attack and its intervention to FeNO. Method 1. Forty patients with moderate attack of bronchial asthma were randomly divided into experimental group and control group with 20 cases in each group. The FeNO values of the two groups were collected, and the clinical symptom score, syndromes curative effect, ACT score, serum IgE, pulmonary function and so on were measured and recorded. 2. 2. In the control group, 20 patients were treated with budesonide formoterol inhaler (xinbiclol), once every time, twice a day, continuously used for 3 months; The experimental group was treated for 3 months in combination with Tongfu Zhuyu decoction on the basis of inhaling Xindu. The clinical symptom score, syndromes efficacy, ACT score, serum IgE, pulmonary function and FeNO were collected and compared again after the course of treatment. Result 1. After treatment, FeNO was decreased, symptom score, ACT score and pulmonary function of serum IgE, were also improved in the two groups (P0.01). Compared with the two groups, the serum IgE of FeNO, in the experimental group was significantly lower than that of the experimental group (P0.01), and the score of bronchial asthma symptom and ACT score were significantly lower than that of the control group (P0.05). The improvement of pulmonary function was not significantly different from that of control group (P0.05). Conclusion Tongfu Zhuyu recipe can reduce FeNO, control airway inflammation in patients with moderate attack of bronchial asthma. It is superior to hormone inhalation therapy in relieving clinical symptoms, and to a certain extent reflects the advantage of integrated traditional Chinese and western medicine in treating bronchial asthma. In order to achieve more patients with bronchial asthma control.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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