肉苁蓉颗粒剂治疗帕金森病便秘的临床研究

发布时间：2018-11-11 19:38

【摘要】：目的：帕金森病(Parkinson's disease,PD)是一类神经系统变性疾病,常见于中老年人。其临床症状分为运动症状以及非运动症状。便秘是PD最常见的非运动症状之一,却不被病人重视,常延误治疗,加重病情。故我们对便秘症状应给予高度重视,及早进行积极、有效的治疗可改善患者的生活质量。肉苁蓉属中医补益药,具有补肾助阳、润肠通便的作用。本课题旨在研究帕金森病便秘的病机,使用肉苁蓉颗粒剂治疗帕金森病的便秘,观察其疗效,以期达到缓解PD患者的症状、改善患者的生活质量的目的。方法：选取2015.04-2016.02南京市中医院(南京中医药大学第三附属医院)脑科住院及门诊的帕金森病患者,试验设计采取随机对照方案,按标准纳入40例帕金森病患者,并随机分为治疗组和对照组,两组均给予常规抗PD药物治疗,治疗组加肉苁蓉颗粒剂10g2次／日,对照组做空白对照,每组各20例患者。每组均以2周为1疗程,治疗2个疗程后进行疗效评价,对比治疗前后的慢性便秘严重度评分量表(CSS)、便秘患者生活质量问卷(PAC-QOL)、帕金森病问卷-39(PDQ-39)评分量表以评估疗效。课题中所有数据的统计学处理均采用SPSS17.0统计软件进行。结论：两组病例在入组时,患者的年龄、性别、疾病分期、病程、西药服用剂量以及CSS评分、PAC-QOL评分、PDQ39评分比较,差异均无统计学意义(P0.05),两组患者的基线基本一致,具有可比性。肉苁蓉可以改善患者的便秘症状,疗效明显优于单纯西药治疗的对照组。肉苁蓉颗粒剂能够有效的改善PD便秘患者的便秘生活质量,但相较于对照组无明显优势。加服肉苁蓉的治疗组与单纯西药治疗的对照组均对帕金森病患者的生活质量有一定的改善作用,但两组之间没有明显差异。说明肉苁蓉颗粒剂对帕金森病患者生活质量的改善无明显优势。
[Abstract]:Objective: Parkinson's disease (Parkinson's disease,PD) is a kind of neurodegenerative disease. The clinical symptoms are divided into motor symptoms and non-motor symptoms. Constipation is one of the most common non-motor symptoms in PD. Therefore, we should attach great importance to constipation symptoms, and early active and effective treatment can improve the quality of life of patients. Cistanche deserticola is a traditional Chinese medicine tonifying the kidney and yang, moisturizing the intestines and defecation. The purpose of this study was to study the pathogenesis of constipation of Parkinson's disease, to use Cistanche granules to treat constipation of Parkinson's disease, and to observe its curative effect in order to relieve the symptoms of PD patients and improve their quality of life. Methods: 40 patients with Parkinson's disease were selected from Nanjing Hospital of traditional Chinese Medicine (the third affiliated Hospital of Nanjing University of traditional Chinese Medicine) from April to February, 2015.The randomized control scheme was used in the experiment, and 40 patients with Parkinson's disease were enrolled according to the standard. They were randomly divided into treatment group and control group. Both groups were treated with routine anti- PD drugs. The treatment group was treated with Cistanche deserticola granules 10g2 times per day, and the control group was used as blank control group with 20 patients in each group. Each group was treated with 2 weeks as a course of treatment, and the curative effect was evaluated after 2 courses of treatment. The quality of life (PAC-QOL) of patients with chronic constipation before and after treatment was compared with the scale of chronic constipation severity score (CSS),) before and after treatment. Parkinson's disease questionnaire-39 (PDQ-39) scale to evaluate efficacy. All the data are processed by SPSS17.0 software. Conclusion: there was no significant difference in age, sex, disease stage, course of disease, dosage of western medicine, CSS score, PAC-QOL score and PDQ39 score between the two groups (P0.05). The baseline of the two groups was basically the same and comparable. Cistanche deserticola can improve the constipation symptoms, and the curative effect is better than the control group treated with western medicine alone. Cistanche deserticola granules can effectively improve the constipation quality of patients with PD constipation, but there is no obvious advantage compared with the control group. The quality of life of patients with Parkinson's disease was improved in both the treatment group treated with Cistanche deserticola and the control group treated with western medicine alone, but there was no significant difference between the two groups. It indicated that Cistanche deserticola granules had no obvious advantage in improving the quality of life of patients with Parkinson's disease.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R277.7

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