针药结合干预痰湿质代谢综合征血脂异常患者的临床研究

发布时间：2018-11-13 14:32

【摘要】：目的:本课题采用前瞻性随机对照试验,通过针药结合治疗与单纯西药治疗作对照,评价治疗前后患者体重、腰围、中医体质积分、甘油三脂(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C,High-density lipoprotein cholesterol)、低密度脂蛋白胆固醇(LDL-C,Low-density lipoprotein cholesterol)的变化差异,探讨针药结合干预痰湿质代谢综合征血脂异常患者的临床疗效,比较针药结合治疗与单纯西药对痰湿质代谢综合征血脂异常患者的疗效差异,为寻求治疗代谢综合征更有效更理想的方法。方法:将2016年5月到2017年2月在佛山市中医院治未病中心就诊的患者,按照符合诊断标准、纳入标准和排除标准的方法,收集痰湿质代谢综合征血脂异常病例60例,随机分为治疗组(针药结合组)和对照组(单纯西药组)各30例。治疗组在生活方式健康教育的基础上,进行耳穴、腹针结合山楂消脂胶囊的治疗。治疗组耳穴取穴:胃、脾、腹、内分泌、神门、三焦穴。每次单侧耳穴用管针针刺,另一侧用耳穴压丸法。腹针取穴:中脘、下腺、气海、关元、双侧天枢、双侧大横、双侧滑肉门、双侧外陵。对照组在生活方式健康教育的基础上口服非诺贝特胶囊,每日晚餐服用1粒,每粒200mg。治疗组与对照组均4周为1个疗程,共治疗2个疗程。患者需在治疗前签署知情同意书,及中医体质量表,治疗2个疗程后再次填写中医体质量表,复查体重、腰围、TG、TC、HDL-C、LDL-C。结果:治疗前对治疗组与对照组进行性别、年龄、体重、腰围、中医体质积分、TG、TC、HDL-C、LDL-C的比较,差异没有统计学意义(p≥0.05),两组间具有可比性。治疗2个疗程后,两组治疗前与治疗后的体重、腰围、中医体质积分、TG、TC、HDL-C、LDL-C比较,差异均具有统计学意义(P0.05)。治疗后两组间在体重、TG、TC、HDL-C、LDL-C的比较上,差异没有统计学意义(p≥0.05),而在腰围及中医体质积分上,差异有统计学意义(P0.05)。结论:1.针药结合组与单纯西药组治疗痰湿质代谢综合征血脂异常患者均有疗效;2.针药结合组对减轻痰湿质代谢综合征血脂异常患者的体重,降低TG、TC、LDL-C,提高HDL-C的疗效与单纯西药组的疗效相当;3.针药结合组对减小痰湿质代谢综合征血脂异常患者的腰围及减小中医体质积分的疗效优于单纯西药组;4.耳穴、腹针结合山楂消脂胶囊是治疗痰湿质代谢综合征血脂异常患者的一种较理想的治疗方法。
[Abstract]:Objective: to evaluate patients' body weight, waist circumference, TCM constitution integral and triglyceride (TG), total cholesterol (TC), before and after treatment by prospective randomized controlled trial. High density lipoprotein cholesterol (HDL-C,High-density lipoprotein cholesterol),) low density lipoprotein cholesterol (LDL-C,Low-density lipoprotein cholesterol) was studied in order to explore the clinical effect of acupuncture combined with medicine on hyperlipidemia in patients with phlegm-wet metabolic syndrome. To compare the curative effect of acupuncture and medicine combined therapy with western medicine on patients with dyslipidemia of phlegm-wet metabolic syndrome, and to seek a more effective and ideal method for the treatment of metabolic syndrome. Methods: from May 2016 to February 2017, 60 patients with dyslipidemia of phlegm-wet metabolic syndrome were collected according to the diagnostic criteria, inclusion criteria and exclusion criteria. They were randomly divided into treatment group (acupuncture combined group) and control group (simple western medicine group). Treatment group on the basis of lifestyle health education, auricular acupoints, abdominal acupuncture combined with Hawthorn Xiaozhi capsule treatment. Treatment group ear points: stomach, spleen, abdomen, endocrine, Shenmen, Sanjiao points. Each side of the auricular point was needled with a tube and the other side with the auricular acupoint pressing pill method. Ventral acupuncture points: Zhongwan, inferior gland, Qihai, Guanyuan, bilateral Tianshu, bilateral big transverse, bilateral sliding meat door, bilateral Wingling. The control group took fenofibrate capsule on the basis of lifestyle health education. Treatment group and control group were 4 weeks as a course of treatment, a total of 2 courses of treatment. Patients should sign informed consent form and TCM physique scale before treatment. After 2 courses of treatment, they should fill in TCM physique scale again, review body weight, waist circumference, TG,TC,HDL-C,LDL-C.. Results: there was no significant difference in sex, age, body weight, waist circumference, physique score and TG,TC,HDL-C,LDL-C between the two groups before treatment (p 鈮，

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