基于GLP-1的作用机制对“连术消渴方”治疗痰热互结型消渴病（2型糖尿病）的临床研究

发布时间：2018-11-19 19:39

【摘要】：目的:通过对66例痰热互结型消渴病(2型糖尿病(T2DM))患者的临床疗效观察,初步评价连术消渴方治疗消渴病的作用机制及是否安全,为中医药治疗消渴病提供了新的方向。方法:随机选取开封市中医院内分泌科门诊符合诊断标准的T2DM患者66例。所有病人均给予糖尿病基础知识宣教,制定合理的饮食及运动治疗处方。在基础治疗前提下,停用原口服降糖药物两周后,改为连术消渴方颗粒剂每日一剂分两次水冲服用。可以根据实际情况对药物剂量增减。观察周期为一个月。观察治疗前后患者的临床症状、空腹及餐后2h血糖(FPG、2h PG)、果糖胺(FMN)、胰高血糖素样肽-1(GLP-1)、总胆固醇(TC)、甘油三脂(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)等的变化。结果:1.治疗前后中医症候总疗效为95.3%。患者的症状积分治疗后较治疗期下降明显(P0.05)。2.治疗后患者的FPG、2h PG、FMN水平较治疗前明显改善(P0.05)。3.患者治疗后的FGLP-1、2h GLP-1水平较治疗前升高,统计有显著差异(P0.05)。4.治疗后患者的TC、TG、LDL-C水平较治疗前降低,统计学有差异(P0.05),HDL-C水平在治疗后比治疗前明显升高(P0.05)。5.治疗过程中患者的血、尿、粪常规检验以及肝肾功能检验都未出现明显的异常。结论:连术消渴方能很好地改善痰热互结型消渴病患者的症状和体征,能够使GLP-1水平升高,可以降低FPG、2h PG、FMN水平,能够有效调节脂代谢紊乱。并考虑连术消渴方的降糖作用可能与GLP-1的水平升高有关。
[Abstract]:Objective: to evaluate the mechanism and safety of Lianchuxiaoke prescription in treating diabetes mellitus (T2DM) by observing the clinical curative effect of 66 patients with type 2 diabetes mellitus (T2DM). It provides a new direction for the treatment of dysentery with traditional Chinese medicine (TCM). Methods: 66 patients with T2DM were randomly selected from the Department of Endocrinology of Kaifeng Chinese Medicine Hospital. All patients were given basic knowledge of diabetes education, the formulation of rational diet and exercise treatment prescriptions. Under the premise of basic treatment, after stopping the oral hypoglycemic drugs for two weeks, Lianchuxiaoke granule was taken twice a day by water. The dosage can be increased or decreased according to the actual situation. The observation period is one month. The clinical symptoms, FPG,2h PG), fructosamine (FMN), glucagon like peptide-1 (GLP-1), total cholesterol (TC), triglyceride (TG), were observed before and after treatment. Changes of high density lipoprotein (HDL-C) and low density lipoprotein (LDL-C). The result is 1: 1. The total curative effect of TCM symptom before and after treatment was 95. 3%. The symptom score of the patients decreased significantly after treatment than in the treatment period (P0.05). The FPG,2h PG,FMN level of patients after treatment was significantly improved compared with that before treatment (P0.05). The level of FGLP-1,2h GLP-1 after treatment was significantly higher than that before treatment (P0.05). The level of TC,TG,LDL-C in patients after treatment was lower than that before treatment, there was statistical difference (P0.05), the level of HDL-C after treatment was significantly higher than that before treatment (P0.05). There were no significant abnormalities in blood, urine, feces and liver-kidney function. Conclusion: Lianchuxiaoke prescription can effectively improve the symptoms and signs of patients with phlegm-heat syndrome, increase the level of GLP-1, decrease the level of FPG,2h PG,FMN, and regulate the disorder of lipid metabolism effectively. The hypoglycemic effect of Lianzhouxiaoke prescription may be related to the increase of GLP-1 level.
【学位授予单位】：河南中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R255.4

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