“安脑颗粒”治疗急性脑梗死之痰瘀互结证的临床疗效观察

发布时间：2018-11-24 09:49

【摘要】：目的：评估安脑颗粒治疗急性脑梗死痰瘀阻络证的临床疗效,为安脑颗粒治疗急性脑梗死提供依据。方法：严格选取60例2015年3月至2016年1月至江苏省中西医结合医院就诊的急性脑梗死患者辨证属痰瘀阻络证,将其随机分为两组：安脑颗粒组(治疗组)和西药组(对照组),每组各30名患者。治疗组在对照组治疗的基础上加用安脑颗粒,每日1剂,早晚两次温服,两组连续治疗,疗程14天。于治疗前、治疗后分别进行中医证候积分、NIHSS积分和Bathel评分,以此为依据评价安脑颗粒疗效,同时在观察过程中记录安全性指标及不良反应。结果：1.经统计检验,两组患者在年龄、性别、治疗前中医证候积分、NIHSS评分及Bathel评分等方面比较均无统计学意义(P0.05),由此说明两组病例具有可比性。2.治疗14天后治疗组和对照组两组的中医证候积分.NIHSS评分均有降低,Bathel评分均有升高,两组治疗前、治疗后评分差异均具有高度统计学意义(P0.01)。3.将治疗组及对照组治疗后中医证候积分.NIHSS评分及Bathel评分进行统计学分析,差异具有统计学意义(P0.05)。结论：安脑颗粒治疗急性脑梗死痰瘀阻络证安全有效,可改善患者中医证候及神经功能缺损症状,提高患者自理能力,较单纯西医治疗疗效明显,为安脑颗粒治疗急性脑梗死提供依据。
[Abstract]:Objective: to evaluate the clinical efficacy of Annao granule in treating acute cerebral infarction with phlegm and blood stasis syndrome. Methods: from March 2015 to January 2016, 60 patients with acute cerebral infarction diagnosed as phlegm and stasis syndrome were randomly divided into two groups: group A (treatment group) and group B (control group). There were 30 patients in each group. In the treatment group, on the basis of the treatment in the control group, Annao granule was added, once a day, twice in the morning and evening, the two groups were treated continuously for 14 days. Before and after treatment, TCM syndromes score, NIHSS score and Bathel score were used to evaluate the efficacy of Annao granule. Meanwhile, safety indexes and adverse reactions were recorded in the course of observation. Results: 1. After statistical test, the two groups of patients in age, gender, TCM syndrome score before treatment, NIHSS score and Bathel score were not statistically significant (P0.05), which showed that the two groups of cases are comparable. 2. After 14 days of treatment, the scores of TCM syndromes, NIHSS scores and Bathel scores in the treatment group and the control group were all decreased, and the differences between the two groups before and after treatment were highly statistically significant (P0.01). The treatment group and control group after treatment of TCM syndrome score, NIHSS score and Bathel score were statistically analyzed, the difference was statistically significant (P0.05). Conclusion: Annao granule is safe and effective in treating phlegm and stagnation of collaterals in patients with acute cerebral infarction. It can improve the symptoms of TCM syndromes and nerve function defects, and improve the self-care ability of patients, which is more effective than that of western medicine alone. To provide evidence for the treatment of acute cerebral infarction with Annao granule.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R277.7

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