麦孜彼子丸对非细菌性前列腺炎大鼠的研究
发布时间：2018-11-26 11:25
【摘要】：目的:研究维药麦孜彼子丸对非细菌性前列腺炎大鼠模型炎症及细胞因子的影响,探讨维药治疗慢性前列腺炎的作用机制。方法:采用角叉菜胶所致大鼠非细菌性前列腺炎模型,随机分成6组,实验组动物给予灌胃治疗,给药42天后处死动物,光镜观察各组动物前列腺组织的病理改变,通过ELISA法检测各组动物血清及前列腺组织中IL-1β、IL-6、TNF-α、PGE2的水平和血清中酸性磷酸酶ACP,PAP,Tr ACP的活性。结果:与模型组比较,麦孜彼子丸给药14g/Kg、28g/kg大鼠的前列腺湿重、白细胞数明显的降低而卵磷脂小体数目生升高,维药麦孜彼子丸7g/kg、14g/kg、28g/kg剂量均抑制了大鼠动物血清中IL-1β、IL-6、TNF-α水平;与模型组比较各组PGE2水平没有显著差异。与模型组比较麦子彼孜丸14g/kg,28g/kg剂量和前列通瘀片组血清中的PAP活性明显低于模型组。而麦孜彼子丸28g/kg和前列通瘀片6g/kg血清中的ACP活性明显低于模型组;与正常组比较模型组和各组Tr ACP之间无明显差异。结论:麦孜彼子丸能够明显减轻模型大鼠前列腺炎症反应。
[Abstract]:Aim: to study the effect of Weiyao Maizi Pill on inflammation and cytokines in rats with non-bacterial prostatitis and to explore the mechanism of treatment of chronic prostatitis. Methods: the rat model of non-bacterial prostatitis induced by carrageenin was randomly divided into 6 groups. The experimental group was treated by gastric perfusion, and the animals were killed 42 days after administration. The pathological changes of prostate tissue in each group were observed under light microscope. The levels of IL-1 尾, IL-6,TNF- 伪, PGE2 in serum and prostate tissue and the activity of acid phosphatase ACP,PAP,Tr ACP in serum were detected by ELISA method. Results: compared with the model group, Meizibizi pill was given 14g / kg Kg / 28g / kg rat prostatic wet weight, white blood cell count decreased obviously, and the number of lecithin bodies increased. The Weiyingmaizibizi pill was 7 g / kg ~ (14 g / kg) of prostatic weight and 14 g 路kg ~ (-1) 路kg ~ (-1) of prostatic gland. 28g/kg dose inhibited the levels of IL-1 尾 and IL-6,TNF- 伪 in serum of rats. There was no significant difference in PGE2 level between each group and model group. Compared with the model group, the serum PAP activity of the Maizi Bizi pill (14g / kg) and Qianlie Tongyu tablet group (28g / kg) was significantly lower than that of the model group. The activity of ACP in the serum of 28g/kg and Qianlietongyu tablets was significantly lower than that of the model group, and there was no significant difference between the model group and the normal group in the activity of ACP between the model group and the control group. Conclusion: maizibizi pill can obviously alleviate the inflammatory reaction of prostate in model rats.
【作者单位】： 新疆维吾尔医学专科学校;复旦大学附属华山医院中西医结合研究所;
【基金】：新疆维吾尔自治区高校科研计划重点项目(项目编号:XJEDU20141067)
【分类号】：R29
本文编号：2358426
[Abstract]:Aim: to study the effect of Weiyao Maizi Pill on inflammation and cytokines in rats with non-bacterial prostatitis and to explore the mechanism of treatment of chronic prostatitis. Methods: the rat model of non-bacterial prostatitis induced by carrageenin was randomly divided into 6 groups. The experimental group was treated by gastric perfusion, and the animals were killed 42 days after administration. The pathological changes of prostate tissue in each group were observed under light microscope. The levels of IL-1 尾, IL-6,TNF- 伪, PGE2 in serum and prostate tissue and the activity of acid phosphatase ACP,PAP,Tr ACP in serum were detected by ELISA method. Results: compared with the model group, Meizibizi pill was given 14g / kg Kg / 28g / kg rat prostatic wet weight, white blood cell count decreased obviously, and the number of lecithin bodies increased. The Weiyingmaizibizi pill was 7 g / kg ~ (14 g / kg) of prostatic weight and 14 g 路kg ~ (-1) 路kg ~ (-1) of prostatic gland. 28g/kg dose inhibited the levels of IL-1 尾 and IL-6,TNF- 伪 in serum of rats. There was no significant difference in PGE2 level between each group and model group. Compared with the model group, the serum PAP activity of the Maizi Bizi pill (14g / kg) and Qianlie Tongyu tablet group (28g / kg) was significantly lower than that of the model group. The activity of ACP in the serum of 28g/kg and Qianlietongyu tablets was significantly lower than that of the model group, and there was no significant difference between the model group and the normal group in the activity of ACP between the model group and the control group. Conclusion: maizibizi pill can obviously alleviate the inflammatory reaction of prostate in model rats.
【作者单位】： 新疆维吾尔医学专科学校;复旦大学附属华山医院中西医结合研究所;
【基金】：新疆维吾尔自治区高校科研计划重点项目(项目编号:XJEDU20141067)
【分类号】：R29
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，本文编号：2358426
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