痛风方治疗湿热夹瘀型痛风临床观察

发布时间：2018-12-06 10:52

【摘要】：目的:通过观察痛风方治疗湿热夹瘀型痛风患者的临床疗效,评价其有效性及安全性。方法:采用随机平行对照方法,将120例患者分为对照组和观察组,各60例,对照组给予口服塞来昔布胶囊0.2 g/次,2次/d。观察组在对照组基础上加服痛风方,1剂/d,两组患者疗程均为2周。分别记录治疗前和治疗后患者休息时关节肿痛分数,关节压痛分数,关节肿胀分数,总分数,关节肿痛指数,关节功能分级,C反应蛋白(CRP),血沉(ESR),D-二聚体(DD-i),血尿酸(UA)水平及生活质量评分(SF-36)的改变,并记录不良反应发生情况。结果:经治疗2周后,观察组临床有效率为87.27%,高于对照组的66.04%(χ2=7.536,P0.05);观察组休息时关节肿痛分数,关节压痛分数,总分数,关节功能评分,CRP,ESR,DD-i,UA均低于对照组(P0.05);观察组关节肿痛指数,生活质量SF-36评分均高于对照组(P0.05)。两组患者不良事件发生率无统计学差异。结论:痛风方联合塞来昔布治疗湿热夹瘀型痛风性关节炎疗效确切,抗炎作用强,安全性好,且能降低血尿酸水平而不诱发痛风急性发作。
[Abstract]:Objective: to evaluate the efficacy and safety of gout prescription in treating gout patients with dampness and heat entrapment. Methods: 120 patients were randomly divided into two groups: control group (n = 60) and observation group (n = 60). The control group was treated with celecoxib capsule 0.2 g / d, twice a day. Observation group on the basis of the control group plus gout prescription, 1 dose per day, two groups of patients were treated for 2 weeks. The swelling and pain score, tenderness score, swelling score, total score, swelling index, function grade, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR),) were recorded before and after treatment. Changes of D-dimer (DD-i), serum uric acid (UA) level and quality of life score (SF-36) were recorded. Results: after 2 weeks of treatment, the clinical effective rate of the observation group was 87.27%, which was higher than that of the control group (66.04%) (蠂 2 / 7.536P 0.05). The scores of joint swelling and pain, joint tenderness, total score, joint function score and CRP,ESR,DD-i,UA in the observation group were lower than those in the control group (P0.05). The index of joint swelling and pain and the SF-36 score of quality of life in the observation group were higher than those in the control group (P0.05). There was no significant difference in the incidence of adverse events between the two groups. Conclusion: gout prescription combined with celecoxib is effective in treating gouty arthritis of damp-heat and stasis type, has strong anti-inflammatory effect, good safety, and can reduce the level of uric acid without inducing acute attack of gout.
【作者单位】：广州中医药大学第一临床医学院;广州中医药大学第一附属医院;
【基金】：国家自然科学基金项目(81573930)
【分类号】：R259

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