倾向指数在慢性再生障碍性贫血中医分型与疗效的应用

发布时间：2018-12-07 07:22

【摘要】：目的应用倾向指数方法,观察慢性再生障碍性贫血中医分型与疗效的关系。方法选择慢性再生障碍性贫血患者387例,采用中西医结合治疗,其中肾阳虚组193例,肾阴虚组194例。倾向指数匹配后,共有患者292例,其中肾阳虚组和肾阴虚组各146例,匹配的比例是75.5%。基线资料匹配后均达到了均衡。对匹配后的主要症状积分和疾病疗效、症候疗效进行统计分析。结果匹配后疾病疗效:肾阳虚组基本治愈38例,缓解48例,明显进步42例,总有效率是87.7%;肾阴虚组分别为57例、29例、20例,有效率是72.6%;两组比较差异有统计学意义(P0.05)。两组主要中医症状积分比较:治疗后肾阳虚组和肾阴虚组各项主要中医证侯积分均较治疗前明显降低,治疗前后差异均有统计学意义(P0.05);其中治疗后肾阳虚组心悸、头晕、乏力、面色口唇、指甲苍白、形寒肢冷积分下降与肾阴虚组比较,差异有统计学意义(P0.05)。中医证候疗效比较:肾阳虚组临床痊愈4例,显效7例,有效88例,总有效率是67.8%;肾阴虚组分别为0例、12例、99例,有效率是76%;组间差别无统计学意义(P=0.170.05)。结论中西医结合治疗慢性再生障碍性贫血在疾病疗效方面肾阳虚组要优于肾阴虚组。
[Abstract]:Objective to observe the relationship between TCM classification and curative effect of chronic aplastic anemia by means of propensity index method. Methods 387 patients with chronic aplastic anemia were treated with the combination of traditional Chinese and western medicine, including 193 cases of kidney yang deficiency group and 194 cases of kidney yin deficiency group. There were 292 patients with deficiency of kidney yang and 146 patients with deficiency of kidney yin. The matching ratio was 75. 5%. The baseline data are balanced after matching. The main symptom score, disease curative effect and symptom curative effect after matching were statistically analyzed. Results after matching, 38 cases of kidney yang deficiency group were cured, 48 cases of remission, 42 cases of obvious improvement, the total effective rate was 87.7%, the effective rate of kidney yin deficiency group was 57 cases, 29 cases, 20 cases, respectively, the effective rate was 72.6 cases. The difference between the two groups was statistically significant (P0.05). Two groups of main TCM symptom score comparison: after the treatment of kidney yang deficiency group and kidney yin deficiency group each major TCM syndromes scores were significantly lower than before treatment the differences before and after treatment were statistically significant (P0.05); After treatment, there were significant differences in palpitation, dizziness, fatigue, facial color lips, pale nails, cold score of cold limbs and kidney yin deficiency group (P0.05). Comparison of TCM syndromes efficacy: 4 cases were cured, 7 cases were effective, 88 cases were effective, the total effective rate was 67.8 cases in the kidney-yang deficiency group, 0 cases, 12 cases, 99 cases in the kidney-yin deficiency group, respectively, the effective rate was 76.4%. There was no significant difference between groups (P = 0.170.05). Conclusion the treatment of chronic aplastic anemia with combination of traditional Chinese and western medicine is better than that of kidney yin deficiency group.
【作者单位】：潍坊医学院;潍坊医学院附属医院中医科;
【基金】：山东省自然基金(ZR2014AQ020) 国家自然科学基金资助项目(81473071) 山东省自然科学基金(ZR2013HM045) 山东省科技发展计划项目(2012YD19013) 山东省中医药科技发展计划项目(2013-244) 2012年潍坊市科技局立项课题(20122020)
【分类号】：R259

【相似文献】