沈阳市某大型国企职工高尿酸血症流行病学调查及中医体质分型研究

发布时间：2018-12-07 16:50

【摘要】：目的:通过流行病学调查,了解沈阳市某大型国企职工高尿酸血症患病率,研究发病人群年龄特点,分析其相关危险因素,探究其中医体质分型病因病机特点。材料与方法:研究对象选自在2016年9月至2016年12月参加公司体检的沈阳市某大型国企车身组装车间1297名职工,经流行病学调查,符合入选研究标准的高尿酸血症患者216例。根据中华中医药学会《中医体质分类与判定》标准归纳入选病例的中医体质分型。采用SPSS17.0统计软件处理相关数据,各中医体质分型间比较用秩和检验,高尿酸血症的相关危险因素用多因素Logistic回归分析,P0.05为差异有统计学意义。结果:1.经流行病学调查发现,高尿酸血症患者216例,患病率为16.95%,均为男性,年龄为(32.77±3.91)岁,血尿酸水平为(515.85±69.93)ummol/L.2.HUA患者中医体质各辩证分型分布情况:湿热质68例(31.48%)、血瘀质63例(29.16%)、痰湿质47例(21.75%)、平和质38例(17.59%)。3.HUA患者采用中医药干预例数为43例,干预率为19.9%。采用西药干预例数为29例,干预率为13.4%。4.经多因素Logisitc回归分析得出,高嘌呤饮食(OR=1.737,OR95%CI:1.153-2.615)、TG(OR=1.258,OR95%CI:0.966-1.638)、LDL-C(OR=1.811,OR95%CI:1.390-2.358)与HUA的发生具有显著相关性(P0.05),是HUA的危险因素。结论:1.该大型国企职工HUA患病率有上升趋势,而且中青年发病人数较往年增加。2.HUA患者中医体质分型分布由高到低依次为次为湿热质、血瘀质、痰湿质、平和质。3.在HUA患者中,使用中药或药膳干预HUA多于使用西药干预。4.高嘌呤饮食、TG、LDL-C是HUA的危险因素,HUA患者今后应控制高嘌呤食物摄入、定期监测血脂、血尿酸水平。
[Abstract]:Objective: to investigate the prevalence of hyperuricemia in workers of a large state-owned enterprise in Shenyang through epidemiological investigation, to study the age characteristics of the affected population, to analyze the related risk factors, and to explore the etiology and pathogenesis of TCM physique classification. Materials and methods: from September 2016 to December 2016, 1297 employees of a large state-owned enterprise body assembly workshop in Shenyang were enrolled in the physical examination. According to the epidemiological investigation, 216 patients with hyperuricemia were enrolled in the study. According to the criteria of TCM constitution classification and judgment, the selected cases were classified. SPSS17.0 statistical software was used to process the relevant data. The rank sum test was used to compare the physique types of TCM and the risk factors of hyperuricemia were analyzed by multivariate Logistic regression analysis. The difference was statistically significant (P0.05). Results: 1. The epidemiological investigation showed that 216 patients with hyperuricemia had a prevalence rate of 16.955.They were all males with an age of (32.77 卤3.91) years. The level of serum uric acid was (515.85 卤69.93). The distribution of TCM physique in ummol/L.2.HUA patients was as follows: 68 cases (31.48%) of dampness and heat, 63 cases (29.16%) of blood stasis, 47 cases (21.75%) of phlegm dampness. 38 cases (17.59%) were mild, 43 cases were treated with traditional Chinese medicine (TCM), the intervention rate was 19.9%. 29 cases were treated with western medicine, the intervention rate was 13. 4. 4. Multivariate Logisitc regression analysis showed that high purine diet (OR=1.737,OR95%CI:1.153-2.615), TG (OR=1.258,OR95%CI:0.966-1.638), LDL-C (OR=1.811,) OR95%CI:1.390-2.358) was significantly correlated with the occurrence of HUA (P 0.05) and was a risk factor for HUA. Conclusion: 1. The prevalence rate of HUA in the workers of this large state-owned enterprise is on the rise, and the number of young and middle-aged patients has increased compared with previous years. The distribution of TCM physique type of 2.HUA patients from high to low is dampness and heat, blood stasis, phlegm and dampness, and calmness. 3. In patients with HUA, intervention of HUA with traditional Chinese medicine or medicinal meal was more than intervention with western medicine. 4. 4. High purine diet, TG,LDL-C is the risk factor of HUA, HUA patients should control high purine food intake, regular monitoring of blood lipids and serum uric acid levels.
【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259

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