育阴清热补冲汤治疗肾阴虚型经间期出血的临床疗效观察

发布时间：2018-12-10 10:11

【摘要】：目的观察育阴清热补冲汤治疗肾阴虚型经间期出血的临床疗效,并将其与中成药宫环养血颗粒合知柏地黄丸对照,观察两组药物治疗后的患者出血的情况、各中医症状以及基础体温的变化情况。初步探讨其作用机理,为育阴清热补冲汤运用到临床治疗提供科学的依据。方法选择符合本课题研究标准且门诊确诊为经间期出血患者60例,随机分为两组,治疗组患者30例,口服自拟方育阴清热补冲汤,对照组患者30例,口服宫环养血颗粒合知柏地黄丸。均于月经周期的第7～10天开始,连续服用10天,共观察三个月经周期。治疗前和治疗期间每个月经周期后均需记录两组患者服用药物后的出血情况、各中医症状的变化情况,治疗期间需每日测定并记录基础体温,最后对患者的疗效、各个单项症状积分、临床症状总积分及基础体温双相曲线的典型人数进行组内及组间的差异性、相关性分析。以上所有数据应用SPSS22.0统计软件进行分析,以检验结果为p0.05为差异有统计学意义。结果1.治疗后,治疗组总有效率86.7%,对照组总有效率80.0%,组间相比,差异具有统计学意义(p0.05),治疗组优于对照组。2.治疗后,两组出血情况及各中医症状均有所改善。治疗前后具有显著差异(p0.01)；出血情况组间相比,差异具有统计学意义(p0.05),各中医症状积分组间相比,无统计学差异(p0.05)。治疗组止血效果优于对照组,改善中医症状方面疗效相当。3.治疗期间,治疗组一、二疗程和二、三疗程的BBT双相曲线典型人数比较均无统计学差异(p0.05),一、三疗程比较差异具有统计学意义(p0.05)；对照组患者治疗一、二、三疗程后的双相曲线典型人数两两比较差异无统计学意义(p0.05)。治疗组药物至少使用三个疗程才可改善BBT双相曲线不典型状态。4.治疗组疗程越长,疗效越好(p0.01)。结论1.育阴清热补冲汤能够有效的治疗肾阴虚型经间期出血,可明显地改善伴随症状和BBT双相曲线不典型状态,且服药时间越长,疗效越好。2.临床观察过程中,服用育阴清热补冲汤无不良反应出现。
[Abstract]:Objective to observe the clinical effect of Yuyin Qingre Buchong decoction (YQRBT) in treating interphase hemorrhage of kidney yin deficiency type, and compare it with traditional Chinese patent medicine Gong Huan Yang Xue granule and Zhibai Dihuang Pill, and observe the bleeding of patients in two groups after drug treatment. Changes of TCM symptoms and basic body temperature. To provide scientific basis for the application of Yuyin Qingre Buchong decoction to clinical treatment. Methods A total of 60 patients with interphase hemorrhage were randomly divided into two groups: the treatment group (n = 30) and the control group (n = 30). Oral Gonghuan Yangxue granule and Zhibai Dihuang pills. They were taken continuously for 10 days from the 7th day of menstrual cycle. Three menstrual cycles were observed. Before treatment and after each menstrual cycle during treatment, the bleeding after taking drugs, the changes of symptoms of each TCM should be recorded, the basic body temperature should be measured and recorded daily during the treatment period, and finally the curative effect on the patients should be recorded. The difference and correlation between groups were analyzed by the typical number of individual symptom score, clinical symptom score and basic body temperature biphasic curve. All the above data were analyzed by SPSS22.0 software. Result 1. After treatment, the total effective rate of the treatment group was 86.7 and the total effective rate of the control group was 80.0. The difference between the two groups was statistically significant (p0.05), and the treatment group was better than the control group. After treatment, the two groups of bleeding and the symptoms of traditional Chinese medicine have been improved. There were significant differences before and after treatment (p0.01), bleeding between groups, the difference was statistically significant (p0.05), there was no statistical difference between the TCM symptom score group (p0.05). The hemostatic effect of the treatment group was better than that of the control group. During the treatment period, there was no significant difference in the typical number of BBT biphasic curves between the first, second and third courses of treatment in the treatment group (p0.05), but there was significant difference between the first and third courses of treatment (p0.05). In the control group, there was no significant difference in the number of patients with bipolar curve after one, two and three courses of treatment (p0.05). Treatment group drug use at least three courses of treatment to improve the BBT bipolar curve atypical state. 4. The longer the course of treatment, the better the curative effect (p 0.01). Conclusion 1. Yuyin Qingre Buchong decoction can effectively treat the kidney yin deficiency type of intermenstrual hemorrhage, can obviously improve the accompanying symptoms and the atypical state of BBT biphasic curve, and the longer the treatment time, the better the curative effect. 2. In the course of clinical observation, there was no adverse reaction after taking Yuyin Qingre Buchong decoction.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R271.11

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