针刺治疗缓解期复发缓解型多发性硬化症:随机对照研究

发布时间：2018-12-17 18:18

【摘要】：目的:评价针刺穴位与穴旁浅刺治疗复发缓解型多发性硬化(RRMS)缓解期患者的疗效差异。方法:将42例RRMS缓解期患者随机分为观察组和对照组,每组21例。观察组予以基础治疗加金针王乐亭经验方"老十针""督脉十三针""手足十二针"及随症加减穴位针刺治疗,对照组予以基础治疗及以上穴位旁开2~3分浅刺不得气治疗,两组均每日针刺1次,每周针刺5 d,每月连续针刺2周、休息2周,共治疗3个月,并随访2年。观察两组患者治疗前及治疗后随访时扩展残疾状态量表(EDSS)评分变化、治疗前后年复发率变化以及治疗后复发间隔时间。结果:观察组随访3、6个月时EDSS评分较治疗前下降(均P0.05);随访12、24个月时EDSS评分上升(均P0.05);对照组随访3、6、12、24个月时,EDSS评分呈持续上升趋势(均P0.05);随访各时点观察组EDSS评分变化值小于对照组(P0.05,P0.01)。两组治疗后年复发率均较治疗前降低(均P0.01),且观察组低于对照组(P0.01);观察组的复发间隔时间较对照组延长[(441.56±65.37)d vs(382.78±59.33)d,P0.01]。结论:针刺王乐亭验方经穴治疗缓解期RRMS患者疗效显著,可以改善神经功能缺损症状,延长发病间隔时限,降低年复发率。
[Abstract]:Objective: to evaluate the difference of therapeutic effect between acupoints and superficial acupoints in the remission stage of recurrent multiple sclerosis (RRMS). Methods: 42 patients with RRMS in remission period were randomly divided into observation group and control group with 21 cases in each group. The observation group was treated with basic treatment plus "old ten needles", "thirteen needles of du vein", "twelve acupuncture of hand and foot" and acupuncture with syndrome and subtractive acupoints, while the control group was treated with basic treatment and 2 ~ 3 points of superficial pricking beside the above acupoints without gas treatment, the observation group was treated with basic treatment plus "old ten needles", "du pulse thirteen needles" and "12 acupuncture points". The two groups were treated with acupuncture once a day for 5 days a week for 2 weeks, rest for 2 weeks, and followed up for 2 years. The changes of (EDSS) score before and after treatment, the annual recurrence rate before and after treatment and the interval between the two groups were observed. Results: the EDSS score of the observation group decreased after 3 months of follow-up (P0.05), the EDSS score of the control group increased at 12 months and 24 months (P0.05), and the EDSS score of the control group continued to increase at the follow-up of 6 days and 24 months (P0.05). The change of EDSS score in the observation group was lower than that in the control group at all time points (P0.05, P0.01). The recurrence rate of the two groups after treatment was lower than that before treatment (P0.01), and the observation group was lower than the control group (P0.01). The interval of recurrence in the observation group was longer than that in the control group [(441.56 卤65.37) d vs (, 382.78 卤59.33) dg, P0.01]. Conclusion: acupuncture with Wang Leting prescription has a significant therapeutic effect on patients with RRMS in remission period. It can improve the symptom of nerve function defect, prolong the time of onset interval and reduce the annual recurrence rate.
【作者单位】：首都医科大学附属北京中医医院针灸中心;北京中医药大学东方医院神经内科;首都医科大学宣武医院神经内科;北京中医药大学;
【基金】：北京市属医院科研培育计划项目:PZ 2016005
【分类号】：R246.6

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