速效降脂舒肝汤治疗非酒精性脂肪肝临床研究

发布时间：2018-12-28 13:27

【摘要】：目的:观察速效降脂舒肝汤治疗非酒精性脂肪肝的临床疗效。方法:78例非酒精性脂肪性肝炎患者随机分为对照组和观察组,每组39例。对照组给予多烯磷脂酰胆碱胶囊,观察组在对照组治疗基础上给予速效降脂舒肝汤。治疗结束后,比较两组血脂、肝功能以及肝纤维化指标的变化,观察肝脏B超和肝脏及脾脏CT检查的变化,并比较临床疗效。结果:与治疗前比较,两组总胆固醇(total cholesterol,TC)、三酰甘油(triacylglycerol,TG)以及低密度脂蛋白(low density lipoprotein,LDL)水平降低(P0.01),高密度脂蛋白(high density lipoprotein,HDL)水平升高(P0.01),总胆红素(total bilirubin,TBIL)、γ-谷氨酰转肽酶(gamma-glutamyl transpeptidase,γ-GT)、丙氨酸转氨酶(alanine aminotransferase,ALT)以及天门冬氨酸氨基转移酶(aspartate amino transferase,AST)水平均降低(P0.01),血清层黏蛋白(laminin,LN)、透明质酸(hyaluronic acid,HA)、Ⅲ型前胶原(procollagen III,PCⅢ)以及Ⅳ型胶原(collagen type IV,Ⅳ-C)水平均降低(P0.01),肝脏B超积分降低(P0.01),肝脾CT比值升高(P0.01);与对照组比较,观察组TC、TG以及LDL水平较低(P0.01),HDL水平较高(P0.01),TBIL、γ-GT、ALT以及AST水平均较低(P0.01),LN、HA、PCⅢ以及Ⅳ-C水平均较低(P0.01),肝脏B超积分较低(P0.01),肝脾CT比值较高(P0.01);对照组有效率为48.72%,观察组有效率为76.92%,两组有效率比较,差异有统计学意义(P0.05)。结论:速效降脂舒肝汤治疗非酒精性脂肪性肝炎临床疗效显著,能抑制肝纤维化,改善肝脏影像学及肝功能。
[Abstract]:Objective: to observe the clinical effect of quick-acting Jiangzhi Shugan decoction on non-alcoholic fatty liver. Methods: 78 patients with non-alcoholic fatty hepatitis were randomly divided into control group and observation group with 39 cases in each group. The control group was given Polyene phosphatidylcholine capsule, and the observation group was given the quick-acting Jiangzhi Shugan decoction on the basis of the treatment in the control group. After the treatment, the changes of serum lipids, liver function and hepatic fibrosis were compared between the two groups, and the changes of liver B-ultrasound and CT examination of liver and spleen were observed, and the clinical efficacy was compared. Results: compared with before treatment, the levels of total cholesterol (total cholesterol,TC), triglyceride (triacylglycerol,TG) and low density lipoprotein (low density lipoprotein,LDL) were decreased (P0.01) and high density lipoprotein (high density lipoprotein,) in both groups. Increased levels of HDL, total bilirubin (total bilirubin,TBIL), gamma-glutamyl transpeptidase, 纬 GT), alanine aminotransferase (alanine aminotransferase,ALT) and aspartate aminotransferase (aspartate amino transferase, The levels of serum laminin (laminin,LN), hyaluronic acid (hyaluronic acid,HA), type 鈪，

本文编号：2394003