中药抗病毒制剂治疗年轻女性宫颈高危型HPV感染的临床观察

发布时间：2018-12-31 20:13

【摘要】：目的：本课题通过对中药抗病毒制剂对比匹多莫德口服液(商品名：芙露饮)治疗湿热下注型年轻女性宫颈高危型人乳头瘤病毒(high-risk Human Papilloma Virus, hrHPV)感染的临床研究,以此来评价中药抗病毒制剂临床治疗的有效性以及安全性。方法：选择符合纳入标准的于2015年6月-2015年12月在常州市中医医院妇科门诊就诊及住院的年龄为25-35岁之间的湿热下注型hrHPV感染患者共60例,将病人随机分为2组,对照组(芙露饮组),治疗组(中药抗病毒制剂组),每组30例,按研究方案进行治疗,通过治疗前后及两组组间对比来评价中药抗病毒制剂的临床疗效,并通过观察治疗组的临床生化指标来评价中药抗病毒制剂的安全性。结果：1.中医临床症候积分的比较：(1)两组治疗前后各项中医症状积分的比较：治疗组在治疗后对湿热下注型年轻女性富颈hrHPV感染患者的各项临床症状均有明显改善。对照组在治疗后对带下情况及全身症状较前无或仅有轻微改善。(2)中医临床症候总积分的比较：治疗组的中医临床症候总积分在治疗前后的比较有显著的统计学意义(p=0.00,p0.01),对照组在治疗前后的临床症候积分方面意义不显著,且两组之间对比,差异具有统计学意义(p0.05)。2.hrHPV病毒载量及转阴率的比较：(1)治疗组与对照组在治疗前后的病毒载量比较均具有显著统计学意义,两组病毒载量治疗前后差值比较有统计学意义(p=0.01,p0.05),且治疗组降低hrHPV病毒载量明显优于对照组,两组对比具有明显差异(p0.05)。(2)对照组在治疗3个月、6个月后转阴率为20%、33.3%,治疗组在治疗3个月、6个月后的转阴率为36.7%、63.3%。两组在治疗3个月、6个月后的转阴率的比较均具有统计学意义(p0.05)。3.治疗前后总有效率的比较：对照组痊愈率为10%,总有效率63.3%,治疗组痊愈率为26.7%,总有效率为86.7%。两组总有效率的比较有显著统计学意义(p=0.00,p0.01)。4.安全性观察：治疗组在治疗3个月、6个月后查肝肾功能、血尿常规、凝血功能、血生化等指标未见明显异常,两组治疗期间未出现与服用药物明显相关的不良反应。结论：中药抗病毒制剂及芙露饮均能够明显缩短年轻女性宫颈hrHPV感染的临床自愈时限,能够清除hrHPV病毒,降低病毒载量,改善患者的临床症状。中西药及早干预治疗有显著的临床治疗意义,且中药治疗效果明显优于西药治疗。中药经济实惠,安全无毒副作用。
[Abstract]:Objective: to study the clinical study on the treatment of high risk human papillomavirus (high-risk Human Papilloma Virus, hrHPV) infection of cervix of young women with dampness and heat by contrasting pidomod oral liquid (commercial name: Fructus decoction) with antiviral preparation of traditional Chinese medicine. To evaluate the efficacy and safety of traditional Chinese medicine antiviral preparations. Methods: a total of 60 patients with hrHPV infection, aged 25-35 years, who were admitted to the department of gynecology of Changzhou traditional Chinese Medicine Hospital from June 2015 to December 2015, were randomly divided into two groups. The control group (Flo Yin group) and the treatment group (traditional Chinese medicine antiviral preparation group), 30 cases in each group, were treated according to the research plan. The clinical efficacy of traditional Chinese medicine antiviral preparation was evaluated by comparison before and after treatment and between the two groups. The safety of traditional Chinese medicine antiviral preparations was evaluated by observing the clinical biochemical indexes of the treatment group. Results: 1. Comparison of TCM clinical symptom scores: (1) comparison of TCM symptom scores before and after treatment: after treatment, the clinical symptoms of young female patients with hrHPV infection with rich neck were obviously improved in the treatment group. In the control group, there was no or only slight improvement in the subband condition and systemic symptoms after treatment. (2) comparison of the total score of TCM clinical symptoms: the total score of TCM clinical symptoms in the treatment group was significantly different before and after treatment. Statistical significance (p0. 00. P0.01), the control group had no significant significance in the clinical symptom score before and after treatment, and the comparison between the two groups, The difference was statistically significant (p0. 05). The comparison of viral load and negative rate of 2.hrHPV: (1) the viral load of treatment group and control group were significantly different before and after treatment. The difference of viral load between the two groups before and after treatment was statistically significant (p0. 01% p0. 05), and the decrease of hrHPV viral load in the treatment group was significantly better than that in the control group. There was significant difference between the two groups (p0. 05). (2). In the control group, the rate of turning negative after 3 months and 6 months was 20 and 33. 3 respectively. In the treatment group, the rate of turning negative after 3 months and 6 months was 36. 7% and 63. 3% respectively. After 3 months and 6 months of treatment, there were significant differences in the rate of negative conversion between the two groups (p 0.05). Comparison of the total effective rate before and after treatment: the cure rate of the control group was 10, the total effective rate was 63.3, the cure rate of the treatment group was 26.7and the total effective rate was 86.7. The total effective rate of the two groups was significantly higher than that of the control group (p0. 00p 0. 01). 4. Safety observation: the liver and kidney function, blood and urine routine, coagulation function and blood biochemistry were not abnormal in the treatment group after 3 months and 6 months, and there were no obvious adverse reactions associated with taking drugs during the treatment period. Conclusion: both antiviral preparations and Fructus decoction can significantly shorten the time limit of self-healing of cervical hrHPV infection in young women, eliminate hrHPV virus, reduce viral load and improve the clinical symptoms of the patients. Early intervention of Chinese and western medicine has significant clinical significance, and the effect of traditional Chinese medicine is obviously better than that of western medicine. Traditional Chinese medicine is economical and safe without toxic side effects.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R271.9

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