痔术后中药外治疗效的Meta分析

发布时间：2019-01-01 09:54

【摘要】：目的:对中药外治法治疗痔术后引起的各种并发症及促进术后伤口愈合的随机对照试验进行系统评价,评估其证据质量及临床疗效,以期为临床决策提供循证医学证据。方法:计算机检索Pub Med、Ovid、Cochrane Library、中国生物医学文献数据库、维普网、万方数据库、中国知网,时间为各电子数据库建库至2014年4月3日,Cochrane Library至2014年第3期。手工检索相关会议及期刊文献。按纳入排除标准对文献进行初筛和复筛。纳入文献采用Rev Man 5.2软件进行Meta分析。结果:研究评价了30个随机对照试验,共纳入3894例痔术后患者,但针对各结局指标纳入研究数量较少。文献质量均较差。5篇文献Meta分析结果提示中药外治能提高痔术后伤口愈合率[RR=1.20,90%CI(1.14,1.25),P0.05],差异具有统计学意义。其余研究进行定性分析,结果显示中药外治法对痔术后水肿、疼痛的治疗及促进伤口愈合具有一定疗效。结论:中药外治法可能对痔术后并发症及伤口愈合的即刻疗效有一定作用,其远期疗效有待进一步长期临床随访观察。需更多高质量、大样本的临床研究证据来评价其疗效及安全性。
[Abstract]:Objective: to evaluate the quality of evidence and clinical efficacy of randomized controlled trials for the treatment of hemorrhoids after hemorrhoids surgery and to provide evidence based evidence for clinical decision-making. Methods: Pub Med,Ovid,Cochrane Library, Chinese Biomedical Literature Database, Weipu Web, Wanfang Database and China knowledge Network were searched by computer. The database was built from April 3, 2014 to April 3, 2014, and issue 3 from April 3, 2014 to April 3, 2014. Manual retrieval of related conferences and journals. The literature was screened and rescreened according to the exclusion criteria. Rev Man 5.2 software was used for Meta analysis. Results: 30 randomized controlled trials were conducted in 3894 patients with hemorrhoids, but the number of outcomes was less. The results of Meta analysis showed that external treatment of traditional Chinese medicine could improve the rate of wound healing after hemorrhoids operation [RR=1.20,90%CI (1.141.25), P0.05], and the difference was statistically significant. The qualitative analysis of other studies showed that external treatment of traditional Chinese medicine had certain curative effect on edema and pain after hemorrhoids operation and promoting wound healing. Conclusion: external treatment of traditional Chinese medicine may have certain effect on postoperative complications of hemorrhoids and immediate curative effect of wound healing. More high-quality, large-sample clinical evidence is needed to evaluate its efficacy and safety.
【作者单位】：上海中医药大学附属岳阳中西医结合医院肛肠科;上海中医药大学附属第七人民医院普外科;
【基金】：国家自然科学基金项目(81273765) 上海市高级中西医结合人才培养项目(ZYSNXD012-RC-ZXY012)
【分类号】：R266

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