养血益肾方对肾性贫血患者微炎症状态的影响和疗效观察

发布时间：2019-01-02 08:57

【摘要】：目的观察养血益肾方治疗肾性贫血患者的临床疗效。方法 106例患者随机分为促红素组38例、养血益肾组39例和强化组(促红素+养血益肾方)39例,分别给予促红素、养血益肾方和促红素+养血益肾方治疗8周,比较各组的疗效及血肌酐(Scr)、白介素-6(IL-6)、血红蛋白(HGB)、红细胞压积(Hct)的变化。结果强化组总有效率为92.31%,明显优于促红素组的78.95%和养血益肾组的69.23%(P0.05或P0.01),而促红素组和养血益肾组比较差别不大(P0.05)。各组治疗后对Scr、IL-6、HGB和Hct的改善均优于治疗前(均P0.01);强化组Scr、IL-6、HGB和Hct的改善均优于促红素组和养血益肾组(均P0.05),促红素组和养血益肾组IL-6、HGB和Hct改善比较差异无统计学意义(均P0.05),而养血益肾组Scr改善优于促红素组(P0.05)。结论养血益肾方对于肾性贫血患者具有纠正贫血、改善肾功能的作用,可能与其清除IL-6有关。
[Abstract]:Objective to observe the clinical effect of Yangxue Yishen recipe in treating renal anemia. Methods 106 patients were randomly divided into three groups: group B (n = 38), group B (n = 39) and group B (n = 39). The curative effect and the changes of serum creatinine (Scr), interleukin-6 (IL-6) and hemoglobin (HGB), hematocrit (Hct) were compared. Results the total effective rate of the strengthening group was 92.31%, which was significantly better than that of the promoting blood group (78.95%) and the nourishing blood group (69.23%) (P0.05 or P0.01), but the difference between the two groups was not significant (P0.05). The improvement of Scr,IL-6,HGB and Hct in each group was better than that before treatment (P0.01). The improvement of Scr,IL-6,HGB and Hct in the enhanced group was better than that in the group of promoting blood and nourishing the kidney (P0.05), but there was no significant difference in the improvement of IL-6,HGB and Hct between the group of promoting blood and the group of nourishing blood and tonifying the kidney (P0.05). The improvement of Scr in the group of nourishing blood and tonifying kidney was better than that in group B (P 0.05). Conclusion Yangxue Yishen prescription can correct anemia and improve renal function in patients with renal anemia, which may be related to its clearance of IL-6.
【作者单位】：湖南中医药大学第二附属医院;湖南省长沙市洪山街道社区卫生服务中心;
【基金】：湖南省中医药管理局资助项目(2015103)
【分类号】：R277.5

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